Impaired Leydig cell reserve and altered serum androgen binding in the aging male.

Abstract:

:The hormonal profile of the aging male reveals an associated decrease in free testosterone and 5 alpha-dihydrotestosterone (DHT) levels and increased luteinizing hormone levels. Later events consist of a decrease in total testosterone, stable DHT, and increased follicle-stimulating hormone and estradiol levels. Although most available information supports the concept of impaired Leydig cell reserve, our study suggests some degree of hypothalamic-pituitary dysfunction. The signal for increased androgen binding with age is not clear. There is a great deal of individual variation in the time of onset of these events.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Hallberg MC,Wieland RG,Zorn EM,Furst BH,Wieland JM

doi

10.1016/s0015-0282(16)41958-8

subject

Has Abstract

pub_date

1976-07-01 00:00:00

pages

812-4

issue

7

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)41958-8

journal_volume

27

pub_type

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