Clinicohistological study of oligodendroglioma and oligoastrocytoma.

abstract：:Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additi...

journal_title：Brain tumor pathology

authors： Kitamura Y,Sasaki H,Yoshida K

更新日期：2017-04-01 00:00:00

abstract：:Intraoperative rapid diagnosis has been a useful neurosurgery tool for maximal resection and minimal morbidity. However, only a few studies have been conducted regarding diagnostic accuracy and associated problems. The present study reviews our experience in treating patients and investigates the accuracy and problems...

journal_title：Brain tumor pathology

authors： Uematsu Y,Owai Y,Okita R,Tanaka Y,Itakura T

更新日期：2007-01-01 00:00:00

abstract：:Medulloblastomas with myogenic differentiation, previously termed medullomyoblastomas, form rare variants of medulloblastomas. Occasional tumors showing combined myogenic differentiation and melanotic tubular structures have also been described. On studying the records of a tertiary-care super specialty hospital, of 8...

journal_title：Brain tumor pathology

authors： Majumdar K,Tyagi I,Saran RK,Sakhuja P,Sharma A

更新日期：2013-01-01 00:00:00

abstract：:A 37-year-old man, a hepatitis B virus carrier due to mother-to-child transmission, had a medical examination in September 2008 in nearby hospitals due to anorexia and weight loss. He was transported to our hospital because computed tomography (CT) detected intracranial lesions, and he had a positive human immunodefic...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Abe K,Osawa S,Yamazaki T,Yasui Y,Fujii K

更新日期：2011-02-01 00:00:00

abstract：:Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a newly introduced tumor entity of uncertain prognosis characterised by a primary diffuse leptomeningeal growth pattern, oligodendroglial-like morphology and dual glial/neuronal differentiation. Predominantly occurring in children, these tumors present as chronic m...

journal_title：Brain tumor pathology

authors： Nambirajan A,Suri V,Kedia S,Goyal K,Malgulwar PB,Khanna G,Panda PK,Gulati S,Garg A,Sharma MC

更新日期：2018-07-01 00:00:00

abstract：:A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...

journal_title：Brain tumor pathology

authors： Miyajima Y,Oka H,Utsuki S,Hagiwara H,Inukai M,Kijima C,Hara A,Yasui Y,Kawano N,Fujii K

更新日期：2013-01-01 00:00:00

abstract：:Xanthogranuloma of the sellar region is a rare clinical observation. Although it was included in the World Health Organization (WHO) brain tumor classification in 2000, its clinical features and pathogenesis remain uncertain. We report herein seven cases of xanthogranuloma of the sellar region who underwent transsphen...

journal_title：Brain tumor pathology

authors： Amano K,Kubo O,Komori T,Tanaka M,Kawamata T,Hori T,Okada Y

更新日期：2013-10-01 00:00:00

abstract：:The present retrospective data analysis was performed to determine whether intraoperative pathological diagnosis (IOD) using frozen section (FS) could clearly distinguish high-grade glioma from WHO grade II gliomas. IOD was retrospectively compared to the pathological diagnosis using permanent paraffin sections (PS) o...

journal_title：Brain tumor pathology

authors： Ishikawa E,Yamamoto T,Satomi K,Matsuda M,Akutsu H,Shibuya M,Nakai K,Sakamoto N,Takano S,Matsumura A

更新日期：2014-07-01 00:00:00

abstract：:To identify differentially expressed genes involved in rat C6 glioma cell differentiation induced by cyclic AMP, we adopted mRNA fingerprinting using arbitrarily primed polymerase chain reaction (PCR) (RAP). Four complementary DNA (cDNA) fragments differentially expressed during differentiation were isolated, and they...

journal_title：Brain tumor pathology

authors： Sakai H,Nakashima S,Nakatani K,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y

更新日期：1997-01-01 00:00:00

abstract：:Accumulating evidence suggests that tissue hypoxia and apoptosis play important roles in the malignant progression of brain tumors. We investigated the relationship of 14-3-3zeta (an apoptosis-related protein), HIF-1α, and VEGF immunohistochemistry, and evaluated the prognostic value of their expression in human brain...

journal_title：Brain tumor pathology

authors： Cao WD,Kawai N,Miyake K,Zhang X,Fei Z,Tamiya T

更新日期：2014-01-01 00:00:00

abstract：:Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of h...

journal_title：Brain tumor pathology

authors： Mizoguchi M,Kuga D,Guan Y,Hata N,Nakamizo A,Yoshimoto K,Sasaki T

更新日期：2011-07-01 00:00:00

abstract：:Papillary tumor of the pineal region (PTPR) was recently added to the 2007 WHO classification of tumors of the central nervous system as a rare pineal tumor. We present a case of a 17-year-old man who developed a 3-cm pineal tumor that was incompletely excised following two operations. The pathological findings presen...

journal_title：Brain tumor pathology

authors： Yano H,Ohe N,Nakayama N,Shinoda J,Iwama T

更新日期：2009-01-01 00:00:00

abstract：:Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...

journal_title：Brain tumor pathology

authors： Yuzawa S,Nishihara H,Tanaka S

更新日期：2016-10-01 00:00:00

abstract：:There is now compelling evidence that gliomas harbor a small population of cells, termed glioma-initiating cells (GICs), characterized by their ability to undergo self-renewal and initiate tumorigenesis. The development of therapeutic strategies targeted toward GIC signaling may improve the treatment of malignant glio...

journal_title：Brain tumor pathology

authors： Natsume A,Kinjo S,Yuki K,Kato T,Ohno M,Motomura K,Iwami K,Wakabayashi T

更新日期：2011-02-01 00:00:00

abstract：:The incidence of hemorrhagic onset in pilocytic astrocytoma and pilomyxoid astrocytoma, and the clinical and histological characteristics, were compared to other types of neuroepithelial tumors or nonhemorrhagic pilocytic astrocytoma by retrospective review of 445 consecutive neuroepithelial tumors treated at our inst...

journal_title：Brain tumor pathology

authors： Shibahara I,Kanamori M,Kumabe T,Endo H,Sonoda Y,Ogawa Y,Watanabe M,Tominaga T

更新日期：2009-01-01 00:00:00

abstract：:Somatic mutations in NRAS, PTEN and AKT1 genes are rarely (~1%) reported in primary NSCLC, but their role in carcinogenesis have been proven. Therefore, we assessed the frequency of them in 145 FFPE tissue samples from CNS metastases of NSCLC using the real-time PCR technique. We identified four (two NRAS and single A...

journal_title：Brain tumor pathology

authors： Nicoś M,Krawczyk P,Jarosz B,Sawicki M,Trojanowski T,Milanowski J

更新日期：2017-01-01 00:00:00

abstract：:Although tissue confirmation is essential for a diagnosis of primary central nervous system large B-cell lymphoma (PCNSBL), accurate assessment may still be difficult, even when tissue is obtained. We report a 59-year-old man, first diagnosed as multiple sclerosis by open biopsy at another institution, who was then co...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Miyazaki T,Yamazaki T,Yasui Y,Fujii K,Kawano N,Tokuyama W,Iwabuchi K,Okayasu I,Yagishita S

更新日期：2010-04-01 00:00:00

abstract：:The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...

journal_title：Brain tumor pathology

authors： Ishi Y,Takamiya S,Seki T,Yamazaki K,Hida K,Hatanaka KC,Ishida Y,Oda Y,Tanaka S,Yamaguchi S

更新日期：2020-07-01 00:00:00

abstract：:Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (...

journal_title：Brain tumor pathology

authors： Ishida A,Shibuya M,Komori T,Nobusawa S,Niimura K,Matsuo S,Hori T

更新日期：2013-01-01 00:00:00

abstract：:Dysembryoplastic neuroepithelial tumor (DNT) is a relatively new nosologic entity. First described in 1988, it is now included in the "neuronal and mixed neuronal-glial tumours" category in the revised 2000 World Health Organization (WHO) Classification of Tumours of the Nervous System. The collective experience of mo...

journal_title：Brain tumor pathology

authors： Kurtkaya-Yapicier O,Elmaci I,Boran B,Kiliç T,Sav A,Pamir MN

更新日期：2002-01-01 00:00:00

abstract：:We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and w...

journal_title：Brain tumor pathology

authors： Sakurada K,Akasaka M,Kuchiki H,Saino M,Mori W,Sato S,Nakazato Y,Kayama T

更新日期：2007-01-01 00:00:00

abstract：:Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...

journal_title：Brain tumor pathology

authors： Takahashi K,Tsuda M,Kanno H,Murata J,Mahabir R,Ishida Y,Kimura T,Tanino M,Nishihara H,Nagashima K,Tanaka S

更新日期：2014-04-01 00:00:00

abstract：:Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...

journal_title：Brain tumor pathology

authors： Asano K,Miyamoto S,Kubo O,Kikkukawa T,Yagihashi A,Ohkuma H

更新日期：2006-04-01 00:00:00

abstract：:Diffuse gliomas are highly infiltrative intracranial tumors, but there are few useful markers for detecting infiltrating glioma cells in the surrounding brain tissue. Doublecortin (DCX) is a microtubule-associated protein (MAP) that plays a crucial role in neuroblast migration. It was recently demonstrated that DCX is...

journal_title：Brain tumor pathology

authors： Masui K,Mawatari SY,Suzuki SO,Iwaki T

更新日期：2008-01-01 00:00:00

abstract：:A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...

journal_title：Brain tumor pathology

authors： Akimoto J,Namatame H,Haraoka J,Kudo M

更新日期：2005-01-01 00:00:00

abstract：:We describe a new case of isolated Langerhans cell histiocytosis (LCH) of the hypothalamus. A 53-year-old female patient presented with polydipsia, headache, anorexia, and fatigue. Neurological imaging revealed a mass projecting from the hypothalamus into the third ventricle. Gross total removal of the tumor was perfo...

journal_title：Brain tumor pathology

authors： Horiguchi K,Fujii T,Nakazato Y

更新日期：2004-01-01 00:00:00

abstract：:The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...

journal_title：Brain tumor pathology

authors： Fukami S,Riemenschneider MJ,Kohno M,Steiger HJ

更新日期：2016-07-01 00:00:00

abstract：:Glioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the inve...

journal_title：Brain tumor pathology

authors： Xu G,Zheng H,Li JY

更新日期：2019-07-01 00:00:00

abstract：:We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...

journal_title：Brain tumor pathology

authors： Zhou Z,Yu M,Yang S,Zhou J,Sun R,Yang G

更新日期：2013-04-01 00:00:00

abstract：:L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. LAT1 also corresponds to tumor-associated gene-1 (TA1), an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells. We have investigate...

journal_title：Brain tumor pathology

authors： Nawashiro H,Otani N,Uozumi Y,Ooigawa H,Toyooka T,Suzuki T,Katoh H,Tsuzuki N,Ohnuki A,Shima K,Shinomiya N,Matsuo H,Kanai Y

更新日期：2005-01-01 00:00:00