Intraoperative pathological diagnosis in 205 glioma patients in the pre-BCNU wafer era: retrospective analysis with intraoperative implantation of BCNU wafers in mind.

abstract：:There is now compelling evidence that gliomas harbor a small population of cells, termed glioma-initiating cells (GICs), characterized by their ability to undergo self-renewal and initiate tumorigenesis. The development of therapeutic strategies targeted toward GIC signaling may improve the treatment of malignant glio...

journal_title：Brain tumor pathology

authors： Natsume A,Kinjo S,Yuki K,Kato T,Ohno M,Motomura K,Iwami K,Wakabayashi T

更新日期：2011-02-01 00:00:00

abstract：:Detection of mutations in the isocitrate dehydrogenase 1 (IDH1) gene is useful for accurate diagnosis of lower grade gliomas, as described in the 2016 World Health Organization classification of tumors of the central nervous system. Conventional analysis tools, including Sanger DNA sequencing and immunohistochemistry,...

journal_title：Brain tumor pathology

authors： Hirano M,Ohka F,Maeda S,Chalise L,Yamamichi A,Aoki K,Kato A,Tanahashi K,Motomura K,Nishimura Y,Hara M,Shinjo K,Kondo Y,Wakabayashi T,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:Lymphocytic infundibulo-neurohypophysitis (LINH) was first reported by Saito et al. and Imura et al. as a cause of idiopathic central diabetes insipidus. Magnetic resonance (MR) imaging with a contrast medium demonstrates thickening of the pituitary stalk, enlargement of the neurohypophysis, or both with homogeneous e...

journal_title：Brain tumor pathology

authors： Abe T

更新日期：2008-01-01 00:00:00

abstract：:An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total ...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Kijima C,Yasui Y,Fujii K,Kawano N

更新日期：2012-04-01 00:00:00

abstract：:Investigations on the NAB2-STAT6 fusion gene in solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have increased since its discovery in 2013. Although several SFTs reported without NAB2-STAT6 fusion gene analysis, we reviewed 546 SFTs/HPCs with NAB2-STAT6 fusion gene analysis in this study and investigated...

journal_title：Brain tumor pathology

authors： Nakada S,Minato H,Nojima T

更新日期：2016-07-01 00:00:00

abstract：:A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...

journal_title：Brain tumor pathology

authors： Akimoto J,Namatame H,Haraoka J,Kudo M

更新日期：2005-01-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...

journal_title：Brain tumor pathology

authors： Komatsu K,Nakanishi Y,Nemoto N,Hori T,Sawada T,Kobayashi M

更新日期：2004-01-01 00:00:00

abstract：:Diffuse gliomas are highly infiltrative intracranial tumors, but there are few useful markers for detecting infiltrating glioma cells in the surrounding brain tissue. Doublecortin (DCX) is a microtubule-associated protein (MAP) that plays a crucial role in neuroblast migration. It was recently demonstrated that DCX is...

journal_title：Brain tumor pathology

authors： Masui K,Mawatari SY,Suzuki SO,Iwaki T

更新日期：2008-01-01 00:00:00

abstract：:The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined. In the current study,...

journal_title：Brain tumor pathology

authors： Yamamichi A,Ohka F,Aoki K,Suzuki H,Kato A,Hirano M,Motomura K,Tanahashi K,Chalise L,Maeda S,Wakabayashi T,Kato Y,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...

journal_title：Brain tumor pathology

authors： Asano K,Miyamoto S,Kubo O,Kikkukawa T,Yagihashi A,Ohkuma H

更新日期：2006-04-01 00:00:00

abstract：:To identify differentially expressed genes involved in rat C6 glioma cell differentiation induced by cyclic AMP, we adopted mRNA fingerprinting using arbitrarily primed polymerase chain reaction (PCR) (RAP). Four complementary DNA (cDNA) fragments differentially expressed during differentiation were isolated, and they...

journal_title：Brain tumor pathology

authors： Sakai H,Nakashima S,Nakatani K,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y

更新日期：1997-01-01 00:00:00

abstract：:We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...

journal_title：Brain tumor pathology

authors： Zhou Z,Yu M,Yang S,Zhou J,Sun R,Yang G

更新日期：2013-04-01 00:00:00

abstract：:We investigated stereotactic intratumoral microinfusion of nimustine (ACNU) in recurrent brain tumors. Eligibility required histologic confirmation of glioma recurrence despite standard radiotherapy and chemotherapy as well as enhancement of the recurrence with gadolinium on magnetic resonance imaging (MRI). A total i...

journal_title：Brain tumor pathology

authors： Wakabayashi T,Yoshida J,Mizuno M,Kajita Y

更新日期：2001-01-01 00:00:00

abstract：:The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstr...

journal_title：Brain tumor pathology

authors： Moriya J,Tanino MA,Takenami T,Endoh T,Urushido M,Kato Y,Wang L,Kimura T,Tsuda M,Nishihara H,Tanaka S,R-IHC Study Group.

更新日期：2016-01-01 00:00:00

abstract：:We observed the histopathological and physiological characteristics of adrenocorticotropic hormone (ACTH)-secreting adenoma cells derived from a rapidly growing pituitary adenoma, which have firm cell attachment and well-preserved hormonal function in a relatively longterm culture. Corticotrophs, obtained from a 43-ye...

journal_title：Brain tumor pathology

authors： Abe T,Tachikawa T,Sasaki A,Taniyama M,Okamura Y,Izumiyama H,Matsumoto K

更新日期：2000-01-01 00:00:00

abstract：:The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...

journal_title：Brain tumor pathology

authors： Tamura M,Zama A,Kurihara H,Kano T,Imai H,Ishiuchi S,Iwai T,Naito I

更新日期：1997-01-01 00:00:00

abstract：:Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases. Gross deletions of the APC gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using the restriction fragmen...

journal_title：Brain tumor pathology

authors： Pećina-Šlaus N,Nikuševa Martić T,Zeljko M,Bulat S

更新日期：2011-07-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumor (AT/RT), a recently established central nervous system tumor entity, occurs in children and is more malignant than medulloblastoma/primitive neuroectodermal tumors (PNET). We report here a case of AT/RT in a male infant who was 9 months old at the time of diagnosis. Magnetic resonance ...

journal_title：Brain tumor pathology

authors： Inenaga C,Toyoshima Y,Mori H,Nishiyama K,Tanaka R,Takahashi H

更新日期：2003-01-01 00:00:00

abstract：:The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...

journal_title：Brain tumor pathology

authors： Ishi Y,Takamiya S,Seki T,Yamazaki K,Hida K,Hatanaka KC,Ishida Y,Oda Y,Tanaka S,Yamaguchi S

更新日期：2020-07-01 00:00:00

abstract：:Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additi...

journal_title：Brain tumor pathology

authors： Kitamura Y,Sasaki H,Yoshida K

更新日期：2017-04-01 00:00:00

abstract：:Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a newly introduced tumor entity of uncertain prognosis characterised by a primary diffuse leptomeningeal growth pattern, oligodendroglial-like morphology and dual glial/neuronal differentiation. Predominantly occurring in children, these tumors present as chronic m...

journal_title：Brain tumor pathology

authors： Nambirajan A,Suri V,Kedia S,Goyal K,Malgulwar PB,Khanna G,Panda PK,Gulati S,Garg A,Sharma MC

更新日期：2018-07-01 00:00:00

abstract：:To elucidate the expression of the MDR1 gene products P-glycoprotein (Pgp) in endothelial cells of newly formed blood microvessels in brain tumors, 30 brain tumors were examined by immunohistochemistry using an anti-Pgp monoclonal antibody, JSB-1. Positive reactions for JSB-1 were detected in endothelial cells in newl...

journal_title：Brain tumor pathology

authors： Sawada T,Kato Y,Sakayori N,Takekawa Y,Kobayashi M

更新日期：1999-01-01 00:00:00

abstract：:With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. Nucleotide analysis of RT-PCR clones revealed no abnormality in the MMAC1 coding sequence in each ca...

journal_title：Brain tumor pathology

authors： Ding X,Endo S,Zhang SJ,Saito T,Kouno M,Kuroiwa T,Washiyama K,Kumanishi T

更新日期：2001-01-01 00:00:00

abstract：:Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) has been proposed to mediate the cellular uptake and clearance of inactivated protease-inhibitor complexes in regulating proteinase activity at the cell surface, which is necessary for cellular migration and invasive processes. In th...

journal_title：Brain tumor pathology

authors： Yamamoto M,Ikeda K,Ohshima K,Tsugu H,Kimura H,Tomonaga M

更新日期：1998-01-01 00:00:00

abstract：:Intraoperative rapid diagnosis has been a useful neurosurgery tool for maximal resection and minimal morbidity. However, only a few studies have been conducted regarding diagnostic accuracy and associated problems. The present study reviews our experience in treating patients and investigates the accuracy and problems...

journal_title：Brain tumor pathology

authors： Uematsu Y,Owai Y,Okita R,Tanaka Y,Itakura T

更新日期：2007-01-01 00:00:00

abstract：:Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...

journal_title：Brain tumor pathology

authors： Takahashi K,Tsuda M,Kanno H,Murata J,Mahabir R,Ishida Y,Kimura T,Tanino M,Nishihara H,Nagashima K,Tanaka S

更新日期：2014-04-01 00:00:00

abstract：:Wilms' tumour-1 (WT-1) protein m-RNA was recently demonstrated in meningiomas, suggesting the potential application of WT-1 immunotherapy in these tumours. The aim of the present study was to analyze the immunohistochemical expression of WT-1 protein, its correlation with the clinico-pathological variables and associa...

journal_title：Brain tumor pathology

authors： Barresi V,Caffo M,Branca G,Vitarelli E,Tuccari G

更新日期：2015-07-01 00:00:00

abstract：:Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of h...

journal_title：Brain tumor pathology

authors： Mizoguchi M,Kuga D,Guan Y,Hata N,Nakamizo A,Yoshimoto K,Sasaki T

更新日期：2011-07-01 00:00:00

abstract：:A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...

journal_title：Brain tumor pathology

authors： Miyajima Y,Oka H,Utsuki S,Hagiwara H,Inukai M,Kijima C,Hara A,Yasui Y,Kawano N,Fujii K

更新日期：2013-01-01 00:00:00

abstract：:Recent reports have suggested an important clinical role for hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter in patients with glioblastomas. Whether MGMT protein expression is correlated with promoter hypermethylation and patient outcomes, however, has not been elucidated. Here we desc...

journal_title：Brain tumor pathology

authors： Araki Y,Mizoguchi M,Yoshimoto K,Shono T,Amano T,Nakamizo A,Suzuki SO,Iwaki T,Sasaki T

更新日期：2011-02-01 00:00:00