Clinicopathological features from long-term observation of a papillary tumor of the pineal region (PTPR): a case report.

abstract：:Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (...

journal_title：Brain tumor pathology

authors： Ishida A,Shibuya M,Komori T,Nobusawa S,Niimura K,Matsuo S,Hori T

更新日期：2013-01-01 00:00:00

abstract：:Epithelioid glioblastomas (E-GBMs) are rare, highly aggressive tumors consisting of closely packed tumor cells with smooth, round cell borders and abundant eosinophilic cytoplasm. They tend to affect younger patients compared with conventional GBM. BRAF V600E mutation is characteristically found in approximately 50% o...

journal_title：Brain tumor pathology

authors： Funata N,Nobusawa S,Yamada R,Shinoura N

更新日期：2016-01-01 00:00:00

abstract：:The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined. In the current study,...

journal_title：Brain tumor pathology

authors： Yamamichi A,Ohka F,Aoki K,Suzuki H,Kato A,Hirano M,Motomura K,Tanahashi K,Chalise L,Maeda S,Wakabayashi T,Kato Y,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:We observed the histopathological and physiological characteristics of adrenocorticotropic hormone (ACTH)-secreting adenoma cells derived from a rapidly growing pituitary adenoma, which have firm cell attachment and well-preserved hormonal function in a relatively longterm culture. Corticotrophs, obtained from a 43-ye...

journal_title：Brain tumor pathology

authors： Abe T,Tachikawa T,Sasaki A,Taniyama M,Okamura Y,Izumiyama H,Matsumoto K

更新日期：2000-01-01 00:00:00

abstract：:L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. LAT1 also corresponds to tumor-associated gene-1 (TA1), an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells. We have investigate...

journal_title：Brain tumor pathology

authors： Nawashiro H,Otani N,Uozumi Y,Ooigawa H,Toyooka T,Suzuki T,Katoh H,Tsuzuki N,Ohnuki A,Shima K,Shinomiya N,Matsuo H,Kanai Y

更新日期：2005-01-01 00:00:00

abstract：:To identify differentially expressed genes involved in rat C6 glioma cell differentiation induced by cyclic AMP, we adopted mRNA fingerprinting using arbitrarily primed polymerase chain reaction (PCR) (RAP). Four complementary DNA (cDNA) fragments differentially expressed during differentiation were isolated, and they...

journal_title：Brain tumor pathology

authors： Sakai H,Nakashima S,Nakatani K,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y

更新日期：1997-01-01 00:00:00

abstract：:The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...

journal_title：Brain tumor pathology

authors： Fukami S,Riemenschneider MJ,Kohno M,Steiger HJ

更新日期：2016-07-01 00:00:00

abstract：:Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...

journal_title：Brain tumor pathology

authors： Yuzawa S,Nishihara H,Tanaka S

更新日期：2016-10-01 00:00:00

abstract：:The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...

journal_title：Brain tumor pathology

authors： Ishi Y,Takamiya S,Seki T,Yamazaki K,Hida K,Hatanaka KC,Ishida Y,Oda Y,Tanaka S,Yamaguchi S

更新日期：2020-07-01 00:00:00

abstract：:Somatic mutations in NRAS, PTEN and AKT1 genes are rarely (~1%) reported in primary NSCLC, but their role in carcinogenesis have been proven. Therefore, we assessed the frequency of them in 145 FFPE tissue samples from CNS metastases of NSCLC using the real-time PCR technique. We identified four (two NRAS and single A...

journal_title：Brain tumor pathology

authors： Nicoś M,Krawczyk P,Jarosz B,Sawicki M,Trojanowski T,Milanowski J

更新日期：2017-01-01 00:00:00

abstract：:The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...

journal_title：Brain tumor pathology

authors： Tamura M,Zama A,Kurihara H,Kano T,Imai H,Ishiuchi S,Iwai T,Naito I

更新日期：1997-01-01 00:00:00

abstract：:We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to rou...

journal_title：Brain tumor pathology

authors： Murakami C,Yoshida Y,Yamazaki T,Yamazaki A,Nakata S,Hokama Y,Ishiuchi S,Akimoto J,Shishido-Hara Y,Yoshimoto Y,Matsumura N,Nobusawa S,Ikota H,Yokoo H

更新日期：2019-07-01 00:00:00

abstract：:Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additi...

journal_title：Brain tumor pathology

authors： Kitamura Y,Sasaki H,Yoshida K

更新日期：2017-04-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...

journal_title：Brain tumor pathology

authors： Komatsu K,Nakanishi Y,Nemoto N,Hori T,Sawada T,Kobayashi M

更新日期：2004-01-01 00:00:00

abstract：:Although antiangiogenic treatment for malignant glioma using bevacizumab in combination with irinotecan chemotherapy has a promising effect on survival, the high incidence of increasing infiltrative tumors can be a problem in resistance to antiangiogenic therapy. In this study, we detected failure of bevacizumab treat...

journal_title：Brain tumor pathology

authors： Takano S,Mashiko R,Osuka S,Ishikawa E,Ohneda O,Matsumura A

更新日期：2010-10-01 00:00:00

abstract：:Congenital malignant gliomas are rare brain tumors about which few reports have been published. We present the clinical course and genetic alterations in an infant with a congenital malignant glioma detected incidentally by ultrasonography at 36 weeks. The tumor occupied the right temporoparietal region, extended to t...

journal_title：Brain tumor pathology

authors： Yamashita S,Ryu S,Miyata S,Uchinokura S,Yokogami K,Uehara H,Moriguchi S,Iwakiri T,Marutsuka K,Ikenoue M,Sawa D,Yamada N,Kodama Y,Takeshima H

更新日期：2012-04-01 00:00:00

abstract：:Lymphocytic infundibulo-neurohypophysitis (LINH) was first reported by Saito et al. and Imura et al. as a cause of idiopathic central diabetes insipidus. Magnetic resonance (MR) imaging with a contrast medium demonstrates thickening of the pituitary stalk, enlargement of the neurohypophysis, or both with homogeneous e...

journal_title：Brain tumor pathology

authors： Abe T

更新日期：2008-01-01 00:00:00

abstract：:A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular ...

journal_title：Brain tumor pathology

authors： Utsuki S,Kawano N,Oka H,Fukushima Y,Kondo K,Tanizaki Y,Yashui Y,Fujii K,Yagishita S

更新日期：2003-01-01 00:00:00

abstract：:Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a newly introduced tumor entity of uncertain prognosis characterised by a primary diffuse leptomeningeal growth pattern, oligodendroglial-like morphology and dual glial/neuronal differentiation. Predominantly occurring in children, these tumors present as chronic m...

journal_title：Brain tumor pathology

authors： Nambirajan A,Suri V,Kedia S,Goyal K,Malgulwar PB,Khanna G,Panda PK,Gulati S,Garg A,Sharma MC

更新日期：2018-07-01 00:00:00

abstract：:Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of 11C-methionine in WHO grades II and III gliomas. Sixty-two patients underwent 11C-methionine positron e...

journal_title：Brain tumor pathology

authors： Ogishima T,Tamura K,Kobayashi D,Inaji M,Hayashi S,Tamura R,Nariai T,Ishii K,Maehara T

更新日期：2017-01-01 00:00:00

abstract：:Accumulating evidence suggests that tissue hypoxia and apoptosis play important roles in the malignant progression of brain tumors. We investigated the relationship of 14-3-3zeta (an apoptosis-related protein), HIF-1α, and VEGF immunohistochemistry, and evaluated the prognostic value of their expression in human brain...

journal_title：Brain tumor pathology

authors： Cao WD,Kawai N,Miyake K,Zhang X,Fei Z,Tamiya T

更新日期：2014-01-01 00:00:00

abstract：:The present retrospective data analysis was performed to determine whether intraoperative pathological diagnosis (IOD) using frozen section (FS) could clearly distinguish high-grade glioma from WHO grade II gliomas. IOD was retrospectively compared to the pathological diagnosis using permanent paraffin sections (PS) o...

journal_title：Brain tumor pathology

authors： Ishikawa E,Yamamoto T,Satomi K,Matsuda M,Akutsu H,Shibuya M,Nakai K,Sakamoto N,Takano S,Matsumura A

更新日期：2014-07-01 00:00:00

abstract：:Xanthogranuloma of the sellar region is a rare clinical observation. Although it was included in the World Health Organization (WHO) brain tumor classification in 2000, its clinical features and pathogenesis remain uncertain. We report herein seven cases of xanthogranuloma of the sellar region who underwent transsphen...

journal_title：Brain tumor pathology

authors： Amano K,Kubo O,Komori T,Tanaka M,Kawamata T,Hori T,Okada Y

更新日期：2013-10-01 00:00:00

abstract：:Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) has been proposed to mediate the cellular uptake and clearance of inactivated protease-inhibitor complexes in regulating proteinase activity at the cell surface, which is necessary for cellular migration and invasive processes. In th...

journal_title：Brain tumor pathology

authors： Yamamoto M,Ikeda K,Ohshima K,Tsugu H,Kimura H,Tomonaga M

更新日期：1998-01-01 00:00:00

abstract：:An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total ...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Kijima C,Yasui Y,Fujii K,Kawano N

更新日期：2012-04-01 00:00:00

abstract：:Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...

journal_title：Brain tumor pathology

authors： Asano K,Miyamoto S,Kubo O,Kikkukawa T,Yagihashi A,Ohkuma H

更新日期：2006-04-01 00:00:00

abstract：:Although tissue confirmation is essential for a diagnosis of primary central nervous system large B-cell lymphoma (PCNSBL), accurate assessment may still be difficult, even when tissue is obtained. We report a 59-year-old man, first diagnosed as multiple sclerosis by open biopsy at another institution, who was then co...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Miyazaki T,Yamazaki T,Yasui Y,Fujii K,Kawano N,Tokuyama W,Iwabuchi K,Okayasu I,Yagishita S

更新日期：2010-04-01 00:00:00

abstract：:Dysembryoplastic neuroepithelial tumor (DNT) is a relatively new nosologic entity. First described in 1988, it is now included in the "neuronal and mixed neuronal-glial tumours" category in the revised 2000 World Health Organization (WHO) Classification of Tumours of the Nervous System. The collective experience of mo...

journal_title：Brain tumor pathology

authors： Kurtkaya-Yapicier O,Elmaci I,Boran B,Kiliç T,Sav A,Pamir MN

更新日期：2002-01-01 00:00:00

abstract：:A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...

journal_title：Brain tumor pathology

authors： Miyajima Y,Oka H,Utsuki S,Hagiwara H,Inukai M,Kijima C,Hara A,Yasui Y,Kawano N,Fujii K

更新日期：2013-01-01 00:00:00

abstract：:Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our stud...

journal_title：Brain tumor pathology

authors： Takada S,Hojo M,Takebe N,Tanigaki K,Miyamoto S

更新日期：2018-10-01 00:00:00