Abstract:
:A 37-year-old man, a hepatitis B virus carrier due to mother-to-child transmission, had a medical examination in September 2008 in nearby hospitals due to anorexia and weight loss. He was transported to our hospital because computed tomography (CT) detected intracranial lesions, and he had a positive human immunodeficiency virus (HIV) antibody test. Head computed tomography (CT) revealed multiple hemorrhagic lesions and enhancement effect, suggesting a thin wall. Also, an enhancement effect was present in the ventricle walls and the subarachnoid space. No accumulation was found in the thallium-201 scintigraphy. The enhancement effect of the ventricle walls and the subarachnoid space disappeared after oral administration of pyrimethamine, sulfadiazine, and calcium folinate, contributing to the diagnosis of an abscess and meningitis due to toxoplasma. However, mass lesions did not reduce. A biopsy was performed on 30 October, and the pathological diagnosis was malignant lymphoma. He died from respiratory function deterioration on 8 November. Lymphoma cells were found in ventricle wall tissue and the subarachnoid space at the autopsy. Toxoplasmosis will typically occur as a brain lesion most commonly in acquired immune deficiency syndrome (AIDS), whereas malignant lymphoma commonly manifests as a brain neoplastic lesion. However, differentiating between images of these lesions is difficult, so diagnosis by early biopsy is recommended.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Utsuki S,Oka H,Abe K,Osawa S,Yamazaki T,Yasui Y,Fujii Kdoi
10.1007/s10014-010-0001-5subject
Has Abstractpub_date
2011-02-01 00:00:00pages
83-7issue
1eissn
1433-7398issn
1861-387Xjournal_volume
28pub_type
杂志文章abstract::Papillary tumor of the pineal region (PTPR) was recently added to the 2007 WHO classification of tumors of the central nervous system as a rare pineal tumor. We present a case of a 17-year-old man who developed a 3-cm pineal tumor that was incompletely excised following two operations. The pathological findings presen...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-009-0246-z
更新日期:2009-01-01 00:00:00
abstract::L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. LAT1 also corresponds to tumor-associated gene-1 (TA1), an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells. We have investigate...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-005-0188-z
更新日期:2005-01-01 00:00:00
abstract::A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0091-3
更新日期:2013-01-01 00:00:00
abstract::The incidence of hemorrhagic onset in pilocytic astrocytoma and pilomyxoid astrocytoma, and the clinical and histological characteristics, were compared to other types of neuroepithelial tumors or nonhemorrhagic pilocytic astrocytoma by retrospective review of 445 consecutive neuroepithelial tumors treated at our inst...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-008-0243-7
更新日期:2009-01-01 00:00:00
abstract::A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478945
更新日期:2003-01-01 00:00:00
abstract::To elucidate the expression of the MDR1 gene products P-glycoprotein (Pgp) in endothelial cells of newly formed blood microvessels in brain tumors, 30 brain tumors were examined by immunohistochemistry using an anti-Pgp monoclonal antibody, JSB-1. Positive reactions for JSB-1 were detected in endothelial cells in newl...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478898
更新日期:1999-01-01 00:00:00
abstract::The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02482184
更新日期:2004-01-01 00:00:00
abstract::Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-006-0197-6
更新日期:2006-04-01 00:00:00
abstract::Congenital malignant gliomas are rare brain tumors about which few reports have been published. We present the clinical course and genetic alterations in an infant with a congenital malignant glioma detected incidentally by ultrasonography at 36 weeks. The tumor occupied the right temporoparietal region, extended to t...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-011-0071-z
更新日期:2012-04-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-016-0252-x
更新日期:2016-07-01 00:00:00
abstract::The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478866
更新日期:1997-01-01 00:00:00
abstract::The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-020-00369-9
更新日期:2020-07-01 00:00:00
abstract::Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-013-0158-9
更新日期:2014-04-01 00:00:00
abstract::Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-016-0271-7
更新日期:2016-10-01 00:00:00
abstract::We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-012-0115-z
更新日期:2013-04-01 00:00:00
abstract::Detection of mutations in the isocitrate dehydrogenase 1 (IDH1) gene is useful for accurate diagnosis of lower grade gliomas, as described in the 2016 World Health Organization classification of tumors of the central nervous system. Conventional analysis tools, including Sanger DNA sequencing and immunohistochemistry,...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-018-0310-7
更新日期:2018-04-01 00:00:00
abstract::We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to rou...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-019-00344-z
更新日期:2019-07-01 00:00:00
abstract::Intraoperative rapid diagnosis has been a useful neurosurgery tool for maximal resection and minimal morbidity. However, only a few studies have been conducted regarding diagnostic accuracy and associated problems. The present study reviews our experience in treating patients and investigates the accuracy and problems...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-007-0219-z
更新日期:2007-01-01 00:00:00
abstract::We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and w...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-006-0210-0
更新日期:2007-01-01 00:00:00
abstract::Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) has been proposed to mediate the cellular uptake and clearance of inactivated protease-inhibitor complexes in regulating proteinase activity at the cell surface, which is necessary for cellular migration and invasive processes. In th...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02482097
更新日期:1998-01-01 00:00:00
abstract::Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of h...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-011-0038-0
更新日期:2011-07-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-008-0234-8
更新日期:2008-01-01 00:00:00
abstract::Recent reports have suggested an important clinical role for hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter in patients with glioblastomas. Whether MGMT protein expression is correlated with promoter hypermethylation and patient outcomes, however, has not been elucidated. Here we desc...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-010-0004-2
更新日期:2011-02-01 00:00:00
abstract::Medulloblastomas with myogenic differentiation, previously termed medullomyoblastomas, form rare variants of medulloblastomas. Occasional tumors showing combined myogenic differentiation and melanotic tubular structures have also been described. On studying the records of a tertiary-care super specialty hospital, of 8...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0102-4
更新日期:2013-01-01 00:00:00
abstract::We investigated stereotactic intratumoral microinfusion of nimustine (ACNU) in recurrent brain tumors. Eligibility required histologic confirmation of glioma recurrence despite standard radiotherapy and chemotherapy as well as enhancement of the recurrence with gadolinium on magnetic resonance imaging (MRI). A total i...
journal_title:Brain tumor pathology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02478921
更新日期:2001-01-01 00:00:00
abstract::Dysembryoplastic neuroepithelial tumor (DNT) is a relatively new nosologic entity. First described in 1988, it is now included in the "neuronal and mixed neuronal-glial tumours" category in the revised 2000 World Health Organization (WHO) Classification of Tumours of the Nervous System. The collective experience of mo...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478934
更新日期:2002-01-01 00:00:00
abstract::An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-011-0074-9
更新日期:2012-04-01 00:00:00
abstract::Somatic mutations in NRAS, PTEN and AKT1 genes are rarely (~1%) reported in primary NSCLC, but their role in carcinogenesis have been proven. Therefore, we assessed the frequency of them in 145 FFPE tissue samples from CNS metastases of NSCLC using the real-time PCR technique. We identified four (two NRAS and single A...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-016-0276-2
更新日期:2017-01-01 00:00:00
abstract::The present retrospective data analysis was performed to determine whether intraoperative pathological diagnosis (IOD) using frozen section (FS) could clearly distinguish high-grade glioma from WHO grade II gliomas. IOD was retrospectively compared to the pathological diagnosis using permanent paraffin sections (PS) o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-014-0177-1
更新日期:2014-07-01 00:00:00
abstract::We observed the histopathological and physiological characteristics of adrenocorticotropic hormone (ACTH)-secreting adenoma cells derived from a rapidly growing pituitary adenoma, which have firm cell attachment and well-preserved hormonal function in a relatively longterm culture. Corticotrophs, obtained from a 43-ye...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02484284
更新日期:2000-01-01 00:00:00