Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells.

abstract：:Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...

journal_title：Brain tumor pathology

authors： Takahashi K,Tsuda M,Kanno H,Murata J,Mahabir R,Ishida Y,Kimura T,Tanino M,Nishihara H,Nagashima K,Tanaka S

更新日期：2014-04-01 00:00:00

abstract：:The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...

journal_title：Brain tumor pathology

authors： Fukami S,Riemenschneider MJ,Kohno M,Steiger HJ

更新日期：2016-07-01 00:00:00

abstract：:A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular ...

journal_title：Brain tumor pathology

authors： Utsuki S,Kawano N,Oka H,Fukushima Y,Kondo K,Tanizaki Y,Yashui Y,Fujii K,Yagishita S

更新日期：2003-01-01 00:00:00

abstract：:Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of 11C-methionine in WHO grades II and III gliomas. Sixty-two patients underwent 11C-methionine positron e...

journal_title：Brain tumor pathology

authors： Ogishima T,Tamura K,Kobayashi D,Inaji M,Hayashi S,Tamura R,Nariai T,Ishii K,Maehara T

更新日期：2017-01-01 00:00:00

abstract：:To elucidate the expression of the MDR1 gene products P-glycoprotein (Pgp) in endothelial cells of newly formed blood microvessels in brain tumors, 30 brain tumors were examined by immunohistochemistry using an anti-Pgp monoclonal antibody, JSB-1. Positive reactions for JSB-1 were detected in endothelial cells in newl...

journal_title：Brain tumor pathology

authors： Sawada T,Kato Y,Sakayori N,Takekawa Y,Kobayashi M

更新日期：1999-01-01 00:00:00

abstract：:With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. Nucleotide analysis of RT-PCR clones revealed no abnormality in the MMAC1 coding sequence in each ca...

journal_title：Brain tumor pathology

authors： Ding X,Endo S,Zhang SJ,Saito T,Kouno M,Kuroiwa T,Washiyama K,Kumanishi T

更新日期：2001-01-01 00:00:00

abstract：:The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...

journal_title：Brain tumor pathology

authors： Tamura M,Zama A,Kurihara H,Kano T,Imai H,Ishiuchi S,Iwai T,Naito I

更新日期：1997-01-01 00:00:00

abstract：:Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a newly introduced tumor entity of uncertain prognosis characterised by a primary diffuse leptomeningeal growth pattern, oligodendroglial-like morphology and dual glial/neuronal differentiation. Predominantly occurring in children, these tumors present as chronic m...

journal_title：Brain tumor pathology

authors： Nambirajan A,Suri V,Kedia S,Goyal K,Malgulwar PB,Khanna G,Panda PK,Gulati S,Garg A,Sharma MC

更新日期：2018-07-01 00:00:00

abstract：:Xanthogranuloma of the sellar region is a rare clinical observation. Although it was included in the World Health Organization (WHO) brain tumor classification in 2000, its clinical features and pathogenesis remain uncertain. We report herein seven cases of xanthogranuloma of the sellar region who underwent transsphen...

journal_title：Brain tumor pathology

authors： Amano K,Kubo O,Komori T,Tanaka M,Kawamata T,Hori T,Okada Y

更新日期：2013-10-01 00:00:00

abstract：:The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstr...

journal_title：Brain tumor pathology

authors： Moriya J,Tanino MA,Takenami T,Endoh T,Urushido M,Kato Y,Wang L,Kimura T,Tsuda M,Nishihara H,Tanaka S,R-IHC Study Group.

更新日期：2016-01-01 00:00:00

abstract：:Congenital malignant gliomas are rare brain tumors about which few reports have been published. We present the clinical course and genetic alterations in an infant with a congenital malignant glioma detected incidentally by ultrasonography at 36 weeks. The tumor occupied the right temporoparietal region, extended to t...

journal_title：Brain tumor pathology

authors： Yamashita S,Ryu S,Miyata S,Uchinokura S,Yokogami K,Uehara H,Moriguchi S,Iwakiri T,Marutsuka K,Ikenoue M,Sawa D,Yamada N,Kodama Y,Takeshima H

更新日期：2012-04-01 00:00:00

abstract：:We describe a new case of isolated Langerhans cell histiocytosis (LCH) of the hypothalamus. A 53-year-old female patient presented with polydipsia, headache, anorexia, and fatigue. Neurological imaging revealed a mass projecting from the hypothalamus into the third ventricle. Gross total removal of the tumor was perfo...

journal_title：Brain tumor pathology

authors： Horiguchi K,Fujii T,Nakazato Y

更新日期：2004-01-01 00:00:00

abstract：:We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...

journal_title：Brain tumor pathology

authors： Zhou Z,Yu M,Yang S,Zhou J,Sun R,Yang G

更新日期：2013-04-01 00:00:00

abstract：:Intraoperative rapid diagnosis has been a useful neurosurgery tool for maximal resection and minimal morbidity. However, only a few studies have been conducted regarding diagnostic accuracy and associated problems. The present study reviews our experience in treating patients and investigates the accuracy and problems...

journal_title：Brain tumor pathology

authors： Uematsu Y,Owai Y,Okita R,Tanaka Y,Itakura T

更新日期：2007-01-01 00:00:00

abstract：:Although antiangiogenic treatment for malignant glioma using bevacizumab in combination with irinotecan chemotherapy has a promising effect on survival, the high incidence of increasing infiltrative tumors can be a problem in resistance to antiangiogenic therapy. In this study, we detected failure of bevacizumab treat...

journal_title：Brain tumor pathology

authors： Takano S,Mashiko R,Osuka S,Ishikawa E,Ohneda O,Matsumura A

更新日期：2010-10-01 00:00:00

abstract：:A 37-year-old man, a hepatitis B virus carrier due to mother-to-child transmission, had a medical examination in September 2008 in nearby hospitals due to anorexia and weight loss. He was transported to our hospital because computed tomography (CT) detected intracranial lesions, and he had a positive human immunodefic...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Abe K,Osawa S,Yamazaki T,Yasui Y,Fujii K

更新日期：2011-02-01 00:00:00

abstract：:Accumulating evidence suggests that tissue hypoxia and apoptosis play important roles in the malignant progression of brain tumors. We investigated the relationship of 14-3-3zeta (an apoptosis-related protein), HIF-1α, and VEGF immunohistochemistry, and evaluated the prognostic value of their expression in human brain...

journal_title：Brain tumor pathology

authors： Cao WD,Kawai N,Miyake K,Zhang X,Fei Z,Tamiya T

更新日期：2014-01-01 00:00:00

abstract：:The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...

journal_title：Brain tumor pathology

authors： Ishi Y,Takamiya S,Seki T,Yamazaki K,Hida K,Hatanaka KC,Ishida Y,Oda Y,Tanaka S,Yamaguchi S

更新日期：2020-07-01 00:00:00

abstract：:A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...

journal_title：Brain tumor pathology

authors： Akimoto J,Namatame H,Haraoka J,Kudo M

更新日期：2005-01-01 00:00:00

abstract：:Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our stud...

journal_title：Brain tumor pathology

authors： Takada S,Hojo M,Takebe N,Tanigaki K,Miyamoto S

更新日期：2018-10-01 00:00:00

abstract：:Medulloblastomas with myogenic differentiation, previously termed medullomyoblastomas, form rare variants of medulloblastomas. Occasional tumors showing combined myogenic differentiation and melanotic tubular structures have also been described. On studying the records of a tertiary-care super specialty hospital, of 8...

journal_title：Brain tumor pathology

authors： Majumdar K,Tyagi I,Saran RK,Sakhuja P,Sharma A

更新日期：2013-01-01 00:00:00

abstract：:Although tissue confirmation is essential for a diagnosis of primary central nervous system large B-cell lymphoma (PCNSBL), accurate assessment may still be difficult, even when tissue is obtained. We report a 59-year-old man, first diagnosed as multiple sclerosis by open biopsy at another institution, who was then co...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Miyazaki T,Yamazaki T,Yasui Y,Fujii K,Kawano N,Tokuyama W,Iwabuchi K,Okayasu I,Yagishita S

更新日期：2010-04-01 00:00:00

abstract：:We observed the histopathological and physiological characteristics of adrenocorticotropic hormone (ACTH)-secreting adenoma cells derived from a rapidly growing pituitary adenoma, which have firm cell attachment and well-preserved hormonal function in a relatively longterm culture. Corticotrophs, obtained from a 43-ye...

journal_title：Brain tumor pathology

authors： Abe T,Tachikawa T,Sasaki A,Taniyama M,Okamura Y,Izumiyama H,Matsumoto K

更新日期：2000-01-01 00:00:00

abstract：:Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases. Gross deletions of the APC gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using the restriction fragmen...

journal_title：Brain tumor pathology

authors： Pećina-Šlaus N,Nikuševa Martić T,Zeljko M,Bulat S

更新日期：2011-07-01 00:00:00

abstract：:There is now compelling evidence that gliomas harbor a small population of cells, termed glioma-initiating cells (GICs), characterized by their ability to undergo self-renewal and initiate tumorigenesis. The development of therapeutic strategies targeted toward GIC signaling may improve the treatment of malignant glio...

journal_title：Brain tumor pathology

authors： Natsume A,Kinjo S,Yuki K,Kato T,Ohno M,Motomura K,Iwami K,Wakabayashi T

更新日期：2011-02-01 00:00:00

abstract：:An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total ...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Kijima C,Yasui Y,Fujii K,Kawano N

更新日期：2012-04-01 00:00:00

abstract：:Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...

journal_title：Brain tumor pathology

authors： Yuzawa S,Nishihara H,Tanaka S

更新日期：2016-10-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumor (AT/RT), a recently established central nervous system tumor entity, occurs in children and is more malignant than medulloblastoma/primitive neuroectodermal tumors (PNET). We report here a case of AT/RT in a male infant who was 9 months old at the time of diagnosis. Magnetic resonance ...

journal_title：Brain tumor pathology

authors： Inenaga C,Toyoshima Y,Mori H,Nishiyama K,Tanaka R,Takahashi H

更新日期：2003-01-01 00:00:00

abstract：:Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (...

journal_title：Brain tumor pathology

authors： Ishida A,Shibuya M,Komori T,Nobusawa S,Niimura K,Matsuo S,Hori T

更新日期：2013-01-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...

journal_title：Brain tumor pathology

authors： Komatsu K,Nakanishi Y,Nemoto N,Hori T,Sawada T,Kobayashi M

更新日期：2004-01-01 00:00:00