Abstract:
:Accumulating evidence suggests that tissue hypoxia and apoptosis play important roles in the malignant progression of brain tumors. We investigated the relationship of 14-3-3zeta (an apoptosis-related protein), HIF-1α, and VEGF immunohistochemistry, and evaluated the prognostic value of their expression in human brain gliomas. A semiquantitative analysis of the immunoreactivity scores (IRSs) of the 14-3-3zeta, HIF-1α, and VEGF proteins was performed in 27 patients with various grades of gliomas. The IRS of 14-3-3zeta increased with tumor grade, with grade IV gliomas having the highest score (P < 0.05). Similar results were found for the IRSs of HIF-1α and VEGF (P < 0.05). A significant positive correlation was found between the IRSs of 14-3-3zeta and HIF-1α, 14-3-3zeta and VEGF, and HIF-1α and VEGF (P < 0.001 for all). The survival time of HIF-1α in grade III and grade IV glioma patients with low IRSs (0-6) was significantly longer than that in such glioma patients with high IRSs (8-12) (P < 0.05). These data indicate that 14-3-3zeta, HIF-1α, and VEGF are involved in the same cascade of the malignant progression of gliomas. Further studies will elucidate their detailed role in the malignant progression of glioma, and will contribute to the development of a new treatment strategy for this lethal disease.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Cao WD,Kawai N,Miyake K,Zhang X,Fei Z,Tamiya Tdoi
10.1007/s10014-013-0135-3subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1-10issue
1eissn
1433-7398issn
1861-387Xjournal_volume
31pub_type
杂志文章abstract::Although antiangiogenic treatment for malignant glioma using bevacizumab in combination with irinotecan chemotherapy has a promising effect on survival, the high incidence of increasing infiltrative tumors can be a problem in resistance to antiangiogenic therapy. In this study, we detected failure of bevacizumab treat...
journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-009-0246-z
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-019-00334-1
更新日期:2019-07-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-016-0276-2
更新日期:2017-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-015-0217-5
更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s10014-008-0243-7
更新日期:2009-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Brain tumor pathology
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