Abstract:
:Congenital malignant gliomas are rare brain tumors about which few reports have been published. We present the clinical course and genetic alterations in an infant with a congenital malignant glioma detected incidentally by ultrasonography at 36 weeks. The tumor occupied the right temporoparietal region, extended to the posterior fossa, and significantly compressed surrounding structures. The female infant was entirely normal without macrocrania, tense fontanel, or sucking difficulties. The tumor was subtotally resected by two-stage surgery; pathological diagnosis was anaplastic astrocytoma. Immunohistochemical staining was positive for p53 and negative for epidermal growth factor receptor. There was no O(6)-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation, no 1p/19q loss of heterozygosity, and no isocitrate dehydrogenase 1 (IDH1) mutation. She underwent postoperative chemotherapy and is alive and well 12 months after surgery.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Yamashita S,Ryu S,Miyata S,Uchinokura S,Yokogami K,Uehara H,Moriguchi S,Iwakiri T,Marutsuka K,Ikenoue M,Sawa D,Yamada N,Kodama Y,Takeshima Hdoi
10.1007/s10014-011-0071-zsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
107-12issue
2eissn
1433-7398issn
1861-387Xjournal_volume
29pub_type
杂志文章abstract::A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...
journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
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更新日期:2017-01-01 00:00:00
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journal_title:Brain tumor pathology
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doi:10.1007/s10014-010-0271-y
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journal_title:Brain tumor pathology
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pub_type: 杂志文章
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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