Abstract:
:Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases. Gross deletions of the APC gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using the restriction fragment length polymorphism method performed by the use of MspI and RsaI genetic markers inside exon 15 and exon 11. Among 21 brain metastases analyzed, 58.8% of samples showed LOH of the APC gene. When assigning the genetic changes to a specific primary tumor type, 6 LOHs were found in metastases originated from lung and 4 LOHs in metastases from colon. The main effector of the wnt signaling, beta-catenin, was upregulated in 42.9% of cases and transferred to the nucleus in 28.6% of metastasis cases. Our findings suggest that genetic changes of the tumor suppressor gene APC, a component of the wnt pathway, represent a part of the brain metastasis genetic profile.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Pećina-Šlaus N,Nikuševa Martić T,Zeljko M,Bulat Sdoi
10.1007/s10014-011-0030-8subject
Has Abstractpub_date
2011-07-01 00:00:00pages
223-8issue
3eissn
1433-7398issn
1861-387Xjournal_volume
28pub_type
杂志文章abstract::An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-011-0074-9
更新日期:2012-04-01 00:00:00
abstract::The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478866
更新日期:1997-01-01 00:00:00
abstract::To elucidate the expression of the MDR1 gene products P-glycoprotein (Pgp) in endothelial cells of newly formed blood microvessels in brain tumors, 30 brain tumors were examined by immunohistochemistry using an anti-Pgp monoclonal antibody, JSB-1. Positive reactions for JSB-1 were detected in endothelial cells in newl...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478898
更新日期:1999-01-01 00:00:00
abstract::Medulloblastomas with myogenic differentiation, previously termed medullomyoblastomas, form rare variants of medulloblastomas. Occasional tumors showing combined myogenic differentiation and melanotic tubular structures have also been described. On studying the records of a tertiary-care super specialty hospital, of 8...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0102-4
更新日期:2013-01-01 00:00:00
abstract::With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. Nucleotide analysis of RT-PCR clones revealed no abnormality in the MMAC1 coding sequence in each ca...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02479427
更新日期:2001-01-01 00:00:00
abstract::The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined. In the current study,...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-018-0312-5
更新日期:2018-04-01 00:00:00
abstract::The incidence of hemorrhagic onset in pilocytic astrocytoma and pilomyxoid astrocytoma, and the clinical and histological characteristics, were compared to other types of neuroepithelial tumors or nonhemorrhagic pilocytic astrocytoma by retrospective review of 445 consecutive neuroepithelial tumors treated at our inst...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-008-0243-7
更新日期:2009-01-01 00:00:00
abstract::We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and w...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-006-0210-0
更新日期:2007-01-01 00:00:00
abstract::Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of h...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-011-0038-0
更新日期:2011-07-01 00:00:00
abstract::Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of 11C-methionine in WHO grades II and III gliomas. Sixty-two patients underwent 11C-methionine positron e...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-017-0280-1
更新日期:2017-01-01 00:00:00
abstract::A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478945
更新日期:2003-01-01 00:00:00
abstract::A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-005-0173-6
更新日期:2005-01-01 00:00:00
abstract::Diffuse gliomas are highly infiltrative intracranial tumors, but there are few useful markers for detecting infiltrating glioma cells in the surrounding brain tissue. Doublecortin (DCX) is a microtubule-associated protein (MAP) that plays a crucial role in neuroblast migration. It was recently demonstrated that DCX is...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-007-0225-1
更新日期:2008-01-01 00:00:00
abstract::Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-013-0158-9
更新日期:2014-04-01 00:00:00
abstract::The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-016-0252-x
更新日期:2016-07-01 00:00:00
abstract::Glioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the inve...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-019-00334-1
更新日期:2019-07-01 00:00:00
abstract::Dysembryoplastic neuroepithelial tumor (DNT) is a relatively new nosologic entity. First described in 1988, it is now included in the "neuronal and mixed neuronal-glial tumours" category in the revised 2000 World Health Organization (WHO) Classification of Tumours of the Nervous System. The collective experience of mo...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478934
更新日期:2002-01-01 00:00:00
abstract::The present retrospective data analysis was performed to determine whether intraoperative pathological diagnosis (IOD) using frozen section (FS) could clearly distinguish high-grade glioma from WHO grade II gliomas. IOD was retrospectively compared to the pathological diagnosis using permanent paraffin sections (PS) o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-014-0177-1
更新日期:2014-07-01 00:00:00
abstract::Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0098-9
更新日期:2013-01-01 00:00:00
abstract::We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-012-0115-z
更新日期:2013-04-01 00:00:00
abstract::The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02482184
更新日期:2004-01-01 00:00:00
abstract::Xanthogranuloma of the sellar region is a rare clinical observation. Although it was included in the World Health Organization (WHO) brain tumor classification in 2000, its clinical features and pathogenesis remain uncertain. We report herein seven cases of xanthogranuloma of the sellar region who underwent transsphen...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0130-0
更新日期:2013-10-01 00:00:00
abstract::Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-006-0197-6
更新日期:2006-04-01 00:00:00
abstract::Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-016-0271-7
更新日期:2016-10-01 00:00:00
abstract::A 37-year-old man, a hepatitis B virus carrier due to mother-to-child transmission, had a medical examination in September 2008 in nearby hospitals due to anorexia and weight loss. He was transported to our hospital because computed tomography (CT) detected intracranial lesions, and he had a positive human immunodefic...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-010-0001-5
更新日期:2011-02-01 00:00:00
abstract::Ollier disease (OD) and Maffucci syndrome are rare conditions due to a post-zygotic somatic mutation that results in mosaicism. In addition to enchondromas and hemangiomas, some of these patients also develop other unrelated tumors, such as gliomas, that harbor IDH mutations, suggesting that an IDH mutation is a commo...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-018-0327-y
更新日期:2018-10-01 00:00:00
abstract::Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our stud...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-018-0323-2
更新日期:2018-10-01 00:00:00
abstract::Recent reports have suggested an important clinical role for hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter in patients with glioblastomas. Whether MGMT protein expression is correlated with promoter hypermethylation and patient outcomes, however, has not been elucidated. Here we desc...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-010-0004-2
更新日期:2011-02-01 00:00:00
abstract::Intraoperative rapid diagnosis has been a useful neurosurgery tool for maximal resection and minimal morbidity. However, only a few studies have been conducted regarding diagnostic accuracy and associated problems. The present study reviews our experience in treating patients and investigates the accuracy and problems...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-007-0219-z
更新日期:2007-01-01 00:00:00
abstract::A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0091-3
更新日期:2013-01-01 00:00:00