Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity.

abstract：:Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...

journal_title：Brain tumor pathology

authors： Asano K,Miyamoto S,Kubo O,Kikkukawa T,Yagihashi A,Ohkuma H

更新日期：2006-04-01 00:00:00

abstract：:To identify differentially expressed genes involved in rat C6 glioma cell differentiation induced by cyclic AMP, we adopted mRNA fingerprinting using arbitrarily primed polymerase chain reaction (PCR) (RAP). Four complementary DNA (cDNA) fragments differentially expressed during differentiation were isolated, and they...

journal_title：Brain tumor pathology

authors： Sakai H,Nakashima S,Nakatani K,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y

更新日期：1997-01-01 00:00:00

abstract：:We investigated stereotactic intratumoral microinfusion of nimustine (ACNU) in recurrent brain tumors. Eligibility required histologic confirmation of glioma recurrence despite standard radiotherapy and chemotherapy as well as enhancement of the recurrence with gadolinium on magnetic resonance imaging (MRI). A total i...

journal_title：Brain tumor pathology

authors： Wakabayashi T,Yoshida J,Mizuno M,Kajita Y

更新日期：2001-01-01 00:00:00

abstract：:Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (...

journal_title：Brain tumor pathology

authors： Ishida A,Shibuya M,Komori T,Nobusawa S,Niimura K,Matsuo S,Hori T

更新日期：2013-01-01 00:00:00

abstract：:L-type amino acid transporter 1 (LAT1), a neutral amino acid transport agent, is essential for the transport of large neutral amino acids. LAT1 also corresponds to tumor-associated gene-1 (TA1), an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells such as glioma cells. We have investigate...

journal_title：Brain tumor pathology

authors： Nawashiro H,Otani N,Uozumi Y,Ooigawa H,Toyooka T,Suzuki T,Katoh H,Tsuzuki N,Ohnuki A,Shima K,Shinomiya N,Matsuo H,Kanai Y

更新日期：2005-01-01 00:00:00

abstract：:Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) has been proposed to mediate the cellular uptake and clearance of inactivated protease-inhibitor complexes in regulating proteinase activity at the cell surface, which is necessary for cellular migration and invasive processes. In th...

journal_title：Brain tumor pathology

authors： Yamamoto M,Ikeda K,Ohshima K,Tsugu H,Kimura H,Tomonaga M

更新日期：1998-01-01 00:00:00

abstract：:The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...

journal_title：Brain tumor pathology

authors： Tamura M,Zama A,Kurihara H,Kano T,Imai H,Ishiuchi S,Iwai T,Naito I

更新日期：1997-01-01 00:00:00

abstract：:The incidence of hemorrhagic onset in pilocytic astrocytoma and pilomyxoid astrocytoma, and the clinical and histological characteristics, were compared to other types of neuroepithelial tumors or nonhemorrhagic pilocytic astrocytoma by retrospective review of 445 consecutive neuroepithelial tumors treated at our inst...

journal_title：Brain tumor pathology

authors： Shibahara I,Kanamori M,Kumabe T,Endo H,Sonoda Y,Ogawa Y,Watanabe M,Tominaga T

更新日期：2009-01-01 00:00:00

abstract：:Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our stud...

journal_title：Brain tumor pathology

authors： Takada S,Hojo M,Takebe N,Tanigaki K,Miyamoto S

更新日期：2018-10-01 00:00:00

abstract：:We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...

journal_title：Brain tumor pathology

authors： Zhou Z,Yu M,Yang S,Zhou J,Sun R,Yang G

更新日期：2013-04-01 00:00:00

abstract：:With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. Nucleotide analysis of RT-PCR clones revealed no abnormality in the MMAC1 coding sequence in each ca...

journal_title：Brain tumor pathology

authors： Ding X,Endo S,Zhang SJ,Saito T,Kouno M,Kuroiwa T,Washiyama K,Kumanishi T

更新日期：2001-01-01 00:00:00

abstract：:There is now compelling evidence that gliomas harbor a small population of cells, termed glioma-initiating cells (GICs), characterized by their ability to undergo self-renewal and initiate tumorigenesis. The development of therapeutic strategies targeted toward GIC signaling may improve the treatment of malignant glio...

journal_title：Brain tumor pathology

authors： Natsume A,Kinjo S,Yuki K,Kato T,Ohno M,Motomura K,Iwami K,Wakabayashi T

更新日期：2011-02-01 00:00:00

abstract：:Xanthogranuloma of the sellar region is a rare clinical observation. Although it was included in the World Health Organization (WHO) brain tumor classification in 2000, its clinical features and pathogenesis remain uncertain. We report herein seven cases of xanthogranuloma of the sellar region who underwent transsphen...

journal_title：Brain tumor pathology

authors： Amano K,Kubo O,Komori T,Tanaka M,Kawamata T,Hori T,Okada Y

更新日期：2013-10-01 00:00:00

abstract：:To elucidate the expression of the MDR1 gene products P-glycoprotein (Pgp) in endothelial cells of newly formed blood microvessels in brain tumors, 30 brain tumors were examined by immunohistochemistry using an anti-Pgp monoclonal antibody, JSB-1. Positive reactions for JSB-1 were detected in endothelial cells in newl...

journal_title：Brain tumor pathology

authors： Sawada T,Kato Y,Sakayori N,Takekawa Y,Kobayashi M

更新日期：1999-01-01 00:00:00

abstract：:Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...

journal_title：Brain tumor pathology

authors： Takahashi K,Tsuda M,Kanno H,Murata J,Mahabir R,Ishida Y,Kimura T,Tanino M,Nishihara H,Nagashima K,Tanaka S

更新日期：2014-04-01 00:00:00

abstract：:Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of 11C-methionine in WHO grades II and III gliomas. Sixty-two patients underwent 11C-methionine positron e...

journal_title：Brain tumor pathology

authors： Ogishima T,Tamura K,Kobayashi D,Inaji M,Hayashi S,Tamura R,Nariai T,Ishii K,Maehara T

更新日期：2017-01-01 00:00:00

abstract：:Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases. Gross deletions of the APC gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using the restriction fragmen...

journal_title：Brain tumor pathology

authors： Pećina-Šlaus N,Nikuševa Martić T,Zeljko M,Bulat S

更新日期：2011-07-01 00:00:00

abstract：:We observed the histopathological and physiological characteristics of adrenocorticotropic hormone (ACTH)-secreting adenoma cells derived from a rapidly growing pituitary adenoma, which have firm cell attachment and well-preserved hormonal function in a relatively longterm culture. Corticotrophs, obtained from a 43-ye...

journal_title：Brain tumor pathology

authors： Abe T,Tachikawa T,Sasaki A,Taniyama M,Okamura Y,Izumiyama H,Matsumoto K

更新日期：2000-01-01 00:00:00

abstract：:The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...

journal_title：Brain tumor pathology

authors： Fukami S,Riemenschneider MJ,Kohno M,Steiger HJ

更新日期：2016-07-01 00:00:00

abstract：:Detection of mutations in the isocitrate dehydrogenase 1 (IDH1) gene is useful for accurate diagnosis of lower grade gliomas, as described in the 2016 World Health Organization classification of tumors of the central nervous system. Conventional analysis tools, including Sanger DNA sequencing and immunohistochemistry,...

journal_title：Brain tumor pathology

authors： Hirano M,Ohka F,Maeda S,Chalise L,Yamamichi A,Aoki K,Kato A,Tanahashi K,Motomura K,Nishimura Y,Hara M,Shinjo K,Kondo Y,Wakabayashi T,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:Papillary tumor of the pineal region (PTPR) was recently added to the 2007 WHO classification of tumors of the central nervous system as a rare pineal tumor. We present a case of a 17-year-old man who developed a 3-cm pineal tumor that was incompletely excised following two operations. The pathological findings presen...

journal_title：Brain tumor pathology

authors： Yano H,Ohe N,Nakayama N,Shinoda J,Iwama T

更新日期：2009-01-01 00:00:00

abstract：:Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additi...

journal_title：Brain tumor pathology

authors： Kitamura Y,Sasaki H,Yoshida K

更新日期：2017-04-01 00:00:00

abstract：:The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstr...

journal_title：Brain tumor pathology

authors： Moriya J,Tanino MA,Takenami T,Endoh T,Urushido M,Kato Y,Wang L,Kimura T,Tsuda M,Nishihara H,Tanaka S,R-IHC Study Group.

更新日期：2016-01-01 00:00:00

abstract：:Ollier disease (OD) and Maffucci syndrome are rare conditions due to a post-zygotic somatic mutation that results in mosaicism. In addition to enchondromas and hemangiomas, some of these patients also develop other unrelated tumors, such as gliomas, that harbor IDH mutations, suggesting that an IDH mutation is a commo...

journal_title：Brain tumor pathology

authors： Tan CL,Vellayappan B,Wu B,Yeo TT,McLendon RE

更新日期：2018-10-01 00:00:00

abstract：:We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to rou...

journal_title：Brain tumor pathology

authors： Murakami C,Yoshida Y,Yamazaki T,Yamazaki A,Nakata S,Hokama Y,Ishiuchi S,Akimoto J,Shishido-Hara Y,Yoshimoto Y,Matsumura N,Nobusawa S,Ikota H,Yokoo H

更新日期：2019-07-01 00:00:00

abstract：:The present retrospective data analysis was performed to determine whether intraoperative pathological diagnosis (IOD) using frozen section (FS) could clearly distinguish high-grade glioma from WHO grade II gliomas. IOD was retrospectively compared to the pathological diagnosis using permanent paraffin sections (PS) o...

journal_title：Brain tumor pathology

authors： Ishikawa E,Yamamoto T,Satomi K,Matsuda M,Akutsu H,Shibuya M,Nakai K,Sakamoto N,Takano S,Matsumura A

更新日期：2014-07-01 00:00:00

abstract：:The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...

journal_title：Brain tumor pathology

authors： Ishi Y,Takamiya S,Seki T,Yamazaki K,Hida K,Hatanaka KC,Ishida Y,Oda Y,Tanaka S,Yamaguchi S

更新日期：2020-07-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...

journal_title：Brain tumor pathology

authors： Komatsu K,Nakanishi Y,Nemoto N,Hori T,Sawada T,Kobayashi M

更新日期：2004-01-01 00:00:00

abstract：:Recent reports have suggested an important clinical role for hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter in patients with glioblastomas. Whether MGMT protein expression is correlated with promoter hypermethylation and patient outcomes, however, has not been elucidated. Here we desc...

journal_title：Brain tumor pathology

authors： Araki Y,Mizoguchi M,Yoshimoto K,Shono T,Amano T,Nakamizo A,Suzuki SO,Iwaki T,Sasaki T

更新日期：2011-02-01 00:00:00

abstract：:Accumulating evidence suggests that tissue hypoxia and apoptosis play important roles in the malignant progression of brain tumors. We investigated the relationship of 14-3-3zeta (an apoptosis-related protein), HIF-1α, and VEGF immunohistochemistry, and evaluated the prognostic value of their expression in human brain...

journal_title：Brain tumor pathology

authors： Cao WD,Kawai N,Miyake K,Zhang X,Fei Z,Tamiya T

更新日期：2014-01-01 00:00:00