Abstract:
:Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our study was to elucidate that stromal cells of central nervous system hemangioblastomas have mesenchymal stem cell-derived vascular progenitor cell properties. Ten hemangioblastomas were investigated immunohistochemically. CD44, a mesenchymal stem cell marker, was detected in stromal cells of all cases, suggesting that stromal cells have mesenchymal stem cell-like properties. Neither CD31 nor α-SMA was expressed in stromal cells, suggesting that stromal cells have not acquired differentiated vascular cell properties. Both ephrin-B2 and EphB4, immature vascular cell markers, were detected in stromal cells of all cases. Jagged1, Notch1, and Hesr2/Hey2, which are known to be detected in both immature endothelial cells and mural cells, were expressed in stromal cells of all cases. Notch3, which is known to be detected in differentiating mural cells, was also expressed in all cases. These results suggest that stromal cells also have vascular progenitor cell properties. In conclusion, stromal cells of hemangioblastomas exhibit mesenchymal stem cell-derived vascular progenitor cell properties.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Takada S,Hojo M,Takebe N,Tanigaki K,Miyamoto Sdoi
10.1007/s10014-018-0323-2subject
Has Abstractpub_date
2018-10-01 00:00:00pages
193-201issue
4eissn
1433-7398issn
1861-387Xpii
10.1007/s10014-018-0323-2journal_volume
35pub_type
杂志文章abstract::Intraoperative rapid diagnosis has been a useful neurosurgery tool for maximal resection and minimal morbidity. However, only a few studies have been conducted regarding diagnostic accuracy and associated problems. The present study reviews our experience in treating patients and investigates the accuracy and problems...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-007-0219-z
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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doi:10.1007/s10014-013-0135-3
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-020-00369-9
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-006-0210-0
更新日期:2007-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-005-0188-z
更新日期:2005-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-018-0312-5
更新日期:2018-04-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478934
更新日期:2002-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-011-0074-9
更新日期:2012-04-01 00:00:00
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journal_title:Brain tumor pathology
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doi:10.1007/s10014-015-0217-5
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pub_type: 杂志文章
doi:10.1007/s10014-012-0102-4
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02484517
更新日期:2004-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478866
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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