High expression of L-type amino acid transporter 1 in infiltrating glioma cells.

abstract：:To elucidate the expression of the MDR1 gene products P-glycoprotein (Pgp) in endothelial cells of newly formed blood microvessels in brain tumors, 30 brain tumors were examined by immunohistochemistry using an anti-Pgp monoclonal antibody, JSB-1. Positive reactions for JSB-1 were detected in endothelial cells in newl...

journal_title：Brain tumor pathology

authors： Sawada T,Kato Y,Sakayori N,Takekawa Y,Kobayashi M

更新日期：1999-01-01 00:00:00

abstract：:Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...

journal_title：Brain tumor pathology

authors： Yuzawa S,Nishihara H,Tanaka S

更新日期：2016-10-01 00:00:00

abstract：:Detection of mutations in the isocitrate dehydrogenase 1 (IDH1) gene is useful for accurate diagnosis of lower grade gliomas, as described in the 2016 World Health Organization classification of tumors of the central nervous system. Conventional analysis tools, including Sanger DNA sequencing and immunohistochemistry,...

journal_title：Brain tumor pathology

authors： Hirano M,Ohka F,Maeda S,Chalise L,Yamamichi A,Aoki K,Kato A,Tanahashi K,Motomura K,Nishimura Y,Hara M,Shinjo K,Kondo Y,Wakabayashi T,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...

journal_title：Brain tumor pathology

authors： Takahashi K,Tsuda M,Kanno H,Murata J,Mahabir R,Ishida Y,Kimura T,Tanino M,Nishihara H,Nagashima K,Tanaka S

更新日期：2014-04-01 00:00:00

abstract：:We investigated stereotactic intratumoral microinfusion of nimustine (ACNU) in recurrent brain tumors. Eligibility required histologic confirmation of glioma recurrence despite standard radiotherapy and chemotherapy as well as enhancement of the recurrence with gadolinium on magnetic resonance imaging (MRI). A total i...

journal_title：Brain tumor pathology

authors： Wakabayashi T,Yoshida J,Mizuno M,Kajita Y

更新日期：2001-01-01 00:00:00

abstract：:Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...

journal_title：Brain tumor pathology

authors： Asano K,Miyamoto S,Kubo O,Kikkukawa T,Yagihashi A,Ohkuma H

更新日期：2006-04-01 00:00:00

abstract：:A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...

journal_title：Brain tumor pathology

authors： Miyajima Y,Oka H,Utsuki S,Hagiwara H,Inukai M,Kijima C,Hara A,Yasui Y,Kawano N,Fujii K

更新日期：2013-01-01 00:00:00

abstract：:Accumulating evidence suggests that tissue hypoxia and apoptosis play important roles in the malignant progression of brain tumors. We investigated the relationship of 14-3-3zeta (an apoptosis-related protein), HIF-1α, and VEGF immunohistochemistry, and evaluated the prognostic value of their expression in human brain...

journal_title：Brain tumor pathology

authors： Cao WD,Kawai N,Miyake K,Zhang X,Fei Z,Tamiya T

更新日期：2014-01-01 00:00:00

abstract：:Xanthogranuloma of the sellar region is a rare clinical observation. Although it was included in the World Health Organization (WHO) brain tumor classification in 2000, its clinical features and pathogenesis remain uncertain. We report herein seven cases of xanthogranuloma of the sellar region who underwent transsphen...

journal_title：Brain tumor pathology

authors： Amano K,Kubo O,Komori T,Tanaka M,Kawamata T,Hori T,Okada Y

更新日期：2013-10-01 00:00:00

abstract：:Glioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the inve...

journal_title：Brain tumor pathology

authors： Xu G,Zheng H,Li JY

更新日期：2019-07-01 00:00:00

abstract：:Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) has been proposed to mediate the cellular uptake and clearance of inactivated protease-inhibitor complexes in regulating proteinase activity at the cell surface, which is necessary for cellular migration and invasive processes. In th...

journal_title：Brain tumor pathology

authors： Yamamoto M,Ikeda K,Ohshima K,Tsugu H,Kimura H,Tomonaga M

更新日期：1998-01-01 00:00:00

abstract：:Recent reports have suggested an important clinical role for hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter in patients with glioblastomas. Whether MGMT protein expression is correlated with promoter hypermethylation and patient outcomes, however, has not been elucidated. Here we desc...

journal_title：Brain tumor pathology

authors： Araki Y,Mizoguchi M,Yoshimoto K,Shono T,Amano T,Nakamizo A,Suzuki SO,Iwaki T,Sasaki T

更新日期：2011-02-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...

journal_title：Brain tumor pathology

authors： Komatsu K,Nakanishi Y,Nemoto N,Hori T,Sawada T,Kobayashi M

更新日期：2004-01-01 00:00:00

abstract：:The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...

journal_title：Brain tumor pathology

authors： Fukami S,Riemenschneider MJ,Kohno M,Steiger HJ

更新日期：2016-07-01 00:00:00

abstract：:Although tissue confirmation is essential for a diagnosis of primary central nervous system large B-cell lymphoma (PCNSBL), accurate assessment may still be difficult, even when tissue is obtained. We report a 59-year-old man, first diagnosed as multiple sclerosis by open biopsy at another institution, who was then co...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Miyazaki T,Yamazaki T,Yasui Y,Fujii K,Kawano N,Tokuyama W,Iwabuchi K,Okayasu I,Yagishita S

更新日期：2010-04-01 00:00:00

abstract：:We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and w...

journal_title：Brain tumor pathology

authors： Sakurada K,Akasaka M,Kuchiki H,Saino M,Mori W,Sato S,Nakazato Y,Kayama T

更新日期：2007-01-01 00:00:00

abstract：:We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to rou...

journal_title：Brain tumor pathology

authors： Murakami C,Yoshida Y,Yamazaki T,Yamazaki A,Nakata S,Hokama Y,Ishiuchi S,Akimoto J,Shishido-Hara Y,Yoshimoto Y,Matsumura N,Nobusawa S,Ikota H,Yokoo H

更新日期：2019-07-01 00:00:00

abstract：:Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our stud...

journal_title：Brain tumor pathology

authors： Takada S,Hojo M,Takebe N,Tanigaki K,Miyamoto S

更新日期：2018-10-01 00:00:00

abstract：:The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstr...

journal_title：Brain tumor pathology

authors： Moriya J,Tanino MA,Takenami T,Endoh T,Urushido M,Kato Y,Wang L,Kimura T,Tsuda M,Nishihara H,Tanaka S,R-IHC Study Group.

更新日期：2016-01-01 00:00:00

abstract：:The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined. In the current study,...

journal_title：Brain tumor pathology

authors： Yamamichi A,Ohka F,Aoki K,Suzuki H,Kato A,Hirano M,Motomura K,Tanahashi K,Chalise L,Maeda S,Wakabayashi T,Kato Y,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of h...

journal_title：Brain tumor pathology

authors： Mizoguchi M,Kuga D,Guan Y,Hata N,Nakamizo A,Yoshimoto K,Sasaki T

更新日期：2011-07-01 00:00:00

abstract：:A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular ...

journal_title：Brain tumor pathology

authors： Utsuki S,Kawano N,Oka H,Fukushima Y,Kondo K,Tanizaki Y,Yashui Y,Fujii K,Yagishita S

更新日期：2003-01-01 00:00:00

abstract：:Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a newly introduced tumor entity of uncertain prognosis characterised by a primary diffuse leptomeningeal growth pattern, oligodendroglial-like morphology and dual glial/neuronal differentiation. Predominantly occurring in children, these tumors present as chronic m...

journal_title：Brain tumor pathology

authors： Nambirajan A,Suri V,Kedia S,Goyal K,Malgulwar PB,Khanna G,Panda PK,Gulati S,Garg A,Sharma MC

更新日期：2018-07-01 00:00:00

abstract：:Diffuse gliomas are highly infiltrative intracranial tumors, but there are few useful markers for detecting infiltrating glioma cells in the surrounding brain tissue. Doublecortin (DCX) is a microtubule-associated protein (MAP) that plays a crucial role in neuroblast migration. It was recently demonstrated that DCX is...

journal_title：Brain tumor pathology

authors： Masui K,Mawatari SY,Suzuki SO,Iwaki T

更新日期：2008-01-01 00:00:00

abstract：:Papillary tumor of the pineal region (PTPR) was recently added to the 2007 WHO classification of tumors of the central nervous system as a rare pineal tumor. We present a case of a 17-year-old man who developed a 3-cm pineal tumor that was incompletely excised following two operations. The pathological findings presen...

journal_title：Brain tumor pathology

authors： Yano H,Ohe N,Nakayama N,Shinoda J,Iwama T

更新日期：2009-01-01 00:00:00

abstract：:With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. Nucleotide analysis of RT-PCR clones revealed no abnormality in the MMAC1 coding sequence in each ca...

journal_title：Brain tumor pathology

authors： Ding X,Endo S,Zhang SJ,Saito T,Kouno M,Kuroiwa T,Washiyama K,Kumanishi T

更新日期：2001-01-01 00:00:00

abstract：:Epithelioid glioblastomas (E-GBMs) are rare, highly aggressive tumors consisting of closely packed tumor cells with smooth, round cell borders and abundant eosinophilic cytoplasm. They tend to affect younger patients compared with conventional GBM. BRAF V600E mutation is characteristically found in approximately 50% o...

journal_title：Brain tumor pathology

authors： Funata N,Nobusawa S,Yamada R,Shinoura N

更新日期：2016-01-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumor (AT/RT), a recently established central nervous system tumor entity, occurs in children and is more malignant than medulloblastoma/primitive neuroectodermal tumors (PNET). We report here a case of AT/RT in a male infant who was 9 months old at the time of diagnosis. Magnetic resonance ...

journal_title：Brain tumor pathology

authors： Inenaga C,Toyoshima Y,Mori H,Nishiyama K,Tanaka R,Takahashi H

更新日期：2003-01-01 00:00:00

abstract：:To identify differentially expressed genes involved in rat C6 glioma cell differentiation induced by cyclic AMP, we adopted mRNA fingerprinting using arbitrarily primed polymerase chain reaction (PCR) (RAP). Four complementary DNA (cDNA) fragments differentially expressed during differentiation were isolated, and they...

journal_title：Brain tumor pathology

authors： Sakai H,Nakashima S,Nakatani K,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y

更新日期：1997-01-01 00:00:00

abstract：:A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...

journal_title：Brain tumor pathology

authors： Akimoto J,Namatame H,Haraoka J,Kudo M

更新日期：2005-01-01 00:00:00