Abstract:
:The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined. In the current study, we performed ATRX-IHC in 78 gliomas whose ATRX statuses were comprehensively determined by whole exome sequencing. Among the 60 IHC-positive and 18 IHC-negative cases, 86.7 and 77.8% were ATRX-wildtype and ATRX-mutant, respectively. ATRX mutational patterns were not consistent with ATRX-IHC. If our cohort had only used IDH status and IHC-based ATRX expression for diagnosis, 78 tumors would have been subtyped as 48 oligodendroglial tumors, 16 IDH-mutant astrocytic tumors, and 14 IDH-wildtype astrocytic tumors. However, when the 1p19q codel test was performed following ATRX-IHC, 8 of 48 ATRX-IHC-positive tumors were classified as "1p19q non-codel" and 3 of 16 ATRX-IHC-negative tumors were classified as "1p19q codel"; a total of 11 tumors (14%) were incorrectly classified. In summary, we observed dissociation between ATRX-IHC and actual 1p19q codel in 11 of 64 IDH-mutant LGGs. In describing the complex IHC expression of ATRX somatic mutations, our results indicate the need for caution when using ATRX-IHC as a surrogate of 1p19q status.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Yamamichi A,Ohka F,Aoki K,Suzuki H,Kato A,Hirano M,Motomura K,Tanahashi K,Chalise L,Maeda S,Wakabayashi T,Kato Y,Natsume Adoi
10.1007/s10014-018-0312-5subject
Has Abstractpub_date
2018-04-01 00:00:00pages
106-113issue
2eissn
1433-7398issn
1861-387Xpii
10.1007/s10014-018-0312-5journal_volume
35pub_type
杂志文章abstract::We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-012-0115-z
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abstract::Dysembryoplastic neuroepithelial tumor (DNT) is a relatively new nosologic entity. First described in 1988, it is now included in the "neuronal and mixed neuronal-glial tumours" category in the revised 2000 World Health Organization (WHO) Classification of Tumours of the Nervous System. The collective experience of mo...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478934
更新日期:2002-01-01 00:00:00
abstract::We observed the histopathological and physiological characteristics of adrenocorticotropic hormone (ACTH)-secreting adenoma cells derived from a rapidly growing pituitary adenoma, which have firm cell attachment and well-preserved hormonal function in a relatively longterm culture. Corticotrophs, obtained from a 43-ye...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02484284
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abstract::The present retrospective data analysis was performed to determine whether intraoperative pathological diagnosis (IOD) using frozen section (FS) could clearly distinguish high-grade glioma from WHO grade II gliomas. IOD was retrospectively compared to the pathological diagnosis using permanent paraffin sections (PS) o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-014-0177-1
更新日期:2014-07-01 00:00:00
abstract::Although tissue confirmation is essential for a diagnosis of primary central nervous system large B-cell lymphoma (PCNSBL), accurate assessment may still be difficult, even when tissue is obtained. We report a 59-year-old man, first diagnosed as multiple sclerosis by open biopsy at another institution, who was then co...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-010-0264-x
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abstract::Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-016-0271-7
更新日期:2016-10-01 00:00:00
abstract::Glioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the inve...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-019-00334-1
更新日期:2019-07-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-010-0011-3
更新日期:2011-02-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-005-0188-z
更新日期:2005-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-015-0239-z
更新日期:2016-01-01 00:00:00
abstract::The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478866
更新日期:1997-01-01 00:00:00
abstract::A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-005-0173-6
更新日期:2005-01-01 00:00:00
abstract::Detection of mutations in the isocitrate dehydrogenase 1 (IDH1) gene is useful for accurate diagnosis of lower grade gliomas, as described in the 2016 World Health Organization classification of tumors of the central nervous system. Conventional analysis tools, including Sanger DNA sequencing and immunohistochemistry,...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-018-0310-7
更新日期:2018-04-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-011-0038-0
更新日期:2011-07-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02484517
更新日期:2004-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0098-9
更新日期:2013-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02483446
更新日期:2003-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-020-00369-9
更新日期:2020-07-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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doi:10.1007/s10014-010-0001-5
更新日期:2011-02-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-013-0135-3
更新日期:2014-01-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02482097
更新日期:1998-01-01 00:00:00
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journal_title:Brain tumor pathology
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doi:10.1007/s10014-012-0130-0
更新日期:2013-10-01 00:00:00
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journal_title:Brain tumor pathology
pub_type: 杂志文章
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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doi:10.1007/s10014-010-0004-2
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journal_title:Brain tumor pathology
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