Abstract:
:Epithelioid glioblastomas (E-GBMs) are rare, highly aggressive tumors consisting of closely packed tumor cells with smooth, round cell borders and abundant eosinophilic cytoplasm. They tend to affect younger patients compared with conventional GBM. BRAF V600E mutation is characteristically found in approximately 50% of all E-GBMs, compared with a low frequency of this mutation in conventional GBM. Here, we report an unusual case of glioma involving the right frontal lobe, basal ganglia and thalamus in an HIV-positive 30-year-old man on antiretroviral therapy. The lesion was composed of abundant discohesive, monotonous epithelioid cells with extensive necrosis, spindle and polyhedral cells, low-grade oligoastrocytoma-like areas, sarcomatous components, and numerous osteoclast-like giant cells (OLGCs) intermingled with epithelioid tumor cells. As the epithelioid cells accounted for more than one-third of the tumor, a pathological diagnosis of E-GBM was made. BRAF V600E mutation was detected in both oligoastrocytoma-like and epithelioid cell components. Similar to previously reported findings on E-GBM associated with low-grade glioma, this case suggested that low-grade astrocytic glioma with BRAF V600E mutation progressed to E-GBM. OLGCs are rarely observed in gliomas, and this is the first case report of E-GBM associated with abundant OLGC infiltration.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Funata N,Nobusawa S,Yamada R,Shinoura Ndoi
10.1007/s10014-015-0239-zsubject
Has Abstractpub_date
2016-01-01 00:00:00pages
57-62issue
1eissn
1433-7398issn
1861-387Xpii
10.1007/s10014-015-0239-zjournal_volume
33pub_type
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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更新日期:2004-01-01 00:00:00
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
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journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
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journal_title:Brain tumor pathology
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