Abstract:
:Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of heterozygosity (LOH) on chromosome 1p/19q and chromosome 10, O6-methylguanine methyltransferase promoter hypermethylation, and mutation of isocitrate dehydrogenase-1--may help to predict patient outcomes. Indeed, LOH analysis is an effective approach to classify malignant gliomas. Genome-wide analyses have revealed that the extent and pattern of LOH regions may have important implications for the clinical course of the disease. As the genetic underpinnings of malignant gliomas are complex and varied, careful selection of the methods for genetic analysis in the clinic is important. The fundamental principles of each assay need to be understood to allow careful selection of practically useful methods. This review summarizes recent developments in the molecular analysis of malignant glioma.
journal_name
Brain Tumor Patholjournal_title
Brain tumor pathologyauthors
Mizoguchi M,Kuga D,Guan Y,Hata N,Nakamizo A,Yoshimoto K,Sasaki Tdoi
10.1007/s10014-011-0038-0subject
Has Abstractpub_date
2011-07-01 00:00:00pages
191-6issue
3eissn
1433-7398issn
1861-387Xjournal_volume
28pub_type
杂志文章,评审abstract::Recent reports have suggested an important clinical role for hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter in patients with glioblastomas. Whether MGMT protein expression is correlated with promoter hypermethylation and patient outcomes, however, has not been elucidated. Here we desc...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-010-0004-2
更新日期:2011-02-01 00:00:00
abstract::The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-016-0252-x
更新日期:2016-07-01 00:00:00
abstract::Papillary tumor of the pineal region (PTPR) was recently added to the 2007 WHO classification of tumors of the central nervous system as a rare pineal tumor. We present a case of a 17-year-old man who developed a 3-cm pineal tumor that was incompletely excised following two operations. The pathological findings presen...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-009-0246-z
更新日期:2009-01-01 00:00:00
abstract::Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additi...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-017-0283-y
更新日期:2017-04-01 00:00:00
abstract::Investigations on the NAB2-STAT6 fusion gene in solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have increased since its discovery in 2013. Although several SFTs reported without NAB2-STAT6 fusion gene analysis, we reviewed 546 SFTs/HPCs with NAB2-STAT6 fusion gene analysis in this study and investigated...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-016-0264-6
更新日期:2016-07-01 00:00:00
abstract::Glioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the inve...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-019-00334-1
更新日期:2019-07-01 00:00:00
abstract::Ollier disease (OD) and Maffucci syndrome are rare conditions due to a post-zygotic somatic mutation that results in mosaicism. In addition to enchondromas and hemangiomas, some of these patients also develop other unrelated tumors, such as gliomas, that harbor IDH mutations, suggesting that an IDH mutation is a commo...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-018-0327-y
更新日期:2018-10-01 00:00:00
abstract::Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a newly introduced tumor entity of uncertain prognosis characterised by a primary diffuse leptomeningeal growth pattern, oligodendroglial-like morphology and dual glial/neuronal differentiation. Predominantly occurring in children, these tumors present as chronic m...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-018-0325-0
更新日期:2018-07-01 00:00:00
abstract::A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478945
更新日期:2003-01-01 00:00:00
abstract::We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to rou...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-019-00344-z
更新日期:2019-07-01 00:00:00
abstract::We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-012-0115-z
更新日期:2013-04-01 00:00:00
abstract::A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-005-0173-6
更新日期:2005-01-01 00:00:00
abstract::Atypical teratoid/rhabdoid tumor (AT/RT), a recently established central nervous system tumor entity, occurs in children and is more malignant than medulloblastoma/primitive neuroectodermal tumors (PNET). We report here a case of AT/RT in a male infant who was 9 months old at the time of diagnosis. Magnetic resonance ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02483446
更新日期:2003-01-01 00:00:00
abstract::Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-016-0271-7
更新日期:2016-10-01 00:00:00
abstract::With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. Nucleotide analysis of RT-PCR clones revealed no abnormality in the MMAC1 coding sequence in each ca...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02479427
更新日期:2001-01-01 00:00:00
abstract::Lymphocytic infundibulo-neurohypophysitis (LINH) was first reported by Saito et al. and Imura et al. as a cause of idiopathic central diabetes insipidus. Magnetic resonance (MR) imaging with a contrast medium demonstrates thickening of the pituitary stalk, enlargement of the neurohypophysis, or both with homogeneous e...
journal_title:Brain tumor pathology
pub_type: 杂志文章,评审
doi:10.1007/s10014-008-0234-8
更新日期:2008-01-01 00:00:00
abstract::Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-013-0158-9
更新日期:2014-04-01 00:00:00
abstract::Accumulating evidence suggests that tissue hypoxia and apoptosis play important roles in the malignant progression of brain tumors. We investigated the relationship of 14-3-3zeta (an apoptosis-related protein), HIF-1α, and VEGF immunohistochemistry, and evaluated the prognostic value of their expression in human brain...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-013-0135-3
更新日期:2014-01-01 00:00:00
abstract::Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-006-0197-6
更新日期:2006-04-01 00:00:00
abstract::We describe a new case of isolated Langerhans cell histiocytosis (LCH) of the hypothalamus. A 53-year-old female patient presented with polydipsia, headache, anorexia, and fatigue. Neurological imaging revealed a mass projecting from the hypothalamus into the third ventricle. Gross total removal of the tumor was perfo...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02484517
更新日期:2004-01-01 00:00:00
abstract::The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstr...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-015-0238-0
更新日期:2016-01-01 00:00:00
abstract::Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of 11C-methionine in WHO grades II and III gliomas. Sixty-two patients underwent 11C-methionine positron e...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-017-0280-1
更新日期:2017-01-01 00:00:00
abstract::To elucidate the expression of the MDR1 gene products P-glycoprotein (Pgp) in endothelial cells of newly formed blood microvessels in brain tumors, 30 brain tumors were examined by immunohistochemistry using an anti-Pgp monoclonal antibody, JSB-1. Positive reactions for JSB-1 were detected in endothelial cells in newl...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478898
更新日期:1999-01-01 00:00:00
abstract::Wilms' tumour-1 (WT-1) protein m-RNA was recently demonstrated in meningiomas, suggesting the potential application of WT-1 immunotherapy in these tumours. The aim of the present study was to analyze the immunohistochemical expression of WT-1 protein, its correlation with the clinico-pathological variables and associa...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-015-0217-5
更新日期:2015-07-01 00:00:00
abstract::An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total ...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-011-0074-9
更新日期:2012-04-01 00:00:00
abstract::A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0091-3
更新日期:2013-01-01 00:00:00
abstract::Xanthogranuloma of the sellar region is a rare clinical observation. Although it was included in the World Health Organization (WHO) brain tumor classification in 2000, its clinical features and pathogenesis remain uncertain. We report herein seven cases of xanthogranuloma of the sellar region who underwent transsphen...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-012-0130-0
更新日期:2013-10-01 00:00:00
abstract::The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-020-00369-9
更新日期:2020-07-01 00:00:00
abstract::The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/BF02478866
更新日期:1997-01-01 00:00:00
abstract::We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and w...
journal_title:Brain tumor pathology
pub_type: 杂志文章
doi:10.1007/s10014-006-0210-0
更新日期:2007-01-01 00:00:00