Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma.

abstract：:Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of h...

journal_title：Brain tumor pathology

authors： Mizoguchi M,Kuga D,Guan Y,Hata N,Nakamizo A,Yoshimoto K,Sasaki T

更新日期：2011-07-01 00:00:00

abstract：:Recent reports have suggested an important clinical role for hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter in patients with glioblastomas. Whether MGMT protein expression is correlated with promoter hypermethylation and patient outcomes, however, has not been elucidated. Here we desc...

journal_title：Brain tumor pathology

authors： Araki Y,Mizoguchi M,Yoshimoto K,Shono T,Amano T,Nakamizo A,Suzuki SO,Iwaki T,Sasaki T

更新日期：2011-02-01 00:00:00

abstract：:Glioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the inve...

journal_title：Brain tumor pathology

authors： Xu G,Zheng H,Li JY

更新日期：2019-07-01 00:00:00

abstract：:The matrix metalloproteinase (MMP) family members catalyze extracellular proteolysis. Recent reports have suggested that expression of MMP-2 and -9 might play a critical role in neoplastic tissue invasion or metastasis. In this study, the relationship between the expression of MMP-2 and -9 and the histological feature...

journal_title：Brain tumor pathology

authors： Komatsu K,Nakanishi Y,Nemoto N,Hori T,Sawada T,Kobayashi M

更新日期：2004-01-01 00:00:00

abstract：:With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis, seven primary brain lymphomas were examined for the state of the MMACI tumor suppressor gene. Nucleotide analysis of RT-PCR clones revealed no abnormality in the MMAC1 coding sequence in each ca...

journal_title：Brain tumor pathology

authors： Ding X,Endo S,Zhang SJ,Saito T,Kouno M,Kuroiwa T,Washiyama K,Kumanishi T

更新日期：2001-01-01 00:00:00

abstract：:Epithelioid glioblastomas (E-GBMs) are rare, highly aggressive tumors consisting of closely packed tumor cells with smooth, round cell borders and abundant eosinophilic cytoplasm. They tend to affect younger patients compared with conventional GBM. BRAF V600E mutation is characteristically found in approximately 50% o...

journal_title：Brain tumor pathology

authors： Funata N,Nobusawa S,Yamada R,Shinoura N

更新日期：2016-01-01 00:00:00

abstract：:The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined. In the current study,...

journal_title：Brain tumor pathology

authors： Yamamichi A,Ohka F,Aoki K,Suzuki H,Kato A,Hirano M,Motomura K,Tanahashi K,Chalise L,Maeda S,Wakabayashi T,Kato Y,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed...

journal_title：Brain tumor pathology

authors： Yuzawa S,Nishihara H,Tanaka S

更新日期：2016-10-01 00:00:00

abstract：:We describe a case of dural angioleiomyoma (ALM) of the middle cranial fossa. A 62-year-old man was referred to our center for fracture of the left clavicle because of a fall, and he had a sudden seizure during admission. The mass was completely resected. The tumor base was located at the bottom of the temporal lobe i...

journal_title：Brain tumor pathology

authors： Zhou Z,Yu M,Yang S,Zhou J,Sun R,Yang G

更新日期：2013-04-01 00:00:00

abstract：:A 37-year-old man, a hepatitis B virus carrier due to mother-to-child transmission, had a medical examination in September 2008 in nearby hospitals due to anorexia and weight loss. He was transported to our hospital because computed tomography (CT) detected intracranial lesions, and he had a positive human immunodefic...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Abe K,Osawa S,Yamazaki T,Yasui Y,Fujii K

更新日期：2011-02-01 00:00:00

abstract：:An 18-year-old girl presented with a history of visual disturbance without headache, nausea, or vomiting in May 2010. In July 2010, the patient visited our hospital because of visual disturbance. Head magnetic resonance images revealed hydrocephalus caused by a ring-enhancing mass lesion located in the vermis. Total ...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Kijima C,Yasui Y,Fujii K,Kawano N

更新日期：2012-04-01 00:00:00

abstract：:Lymphocytic infundibulo-neurohypophysitis (LINH) was first reported by Saito et al. and Imura et al. as a cause of idiopathic central diabetes insipidus. Magnetic resonance (MR) imaging with a contrast medium demonstrates thickening of the pituitary stalk, enlargement of the neurohypophysis, or both with homogeneous e...

journal_title：Brain tumor pathology

authors： Abe T

更新日期：2008-01-01 00:00:00

abstract：:Although tissue confirmation is essential for a diagnosis of primary central nervous system large B-cell lymphoma (PCNSBL), accurate assessment may still be difficult, even when tissue is obtained. We report a 59-year-old man, first diagnosed as multiple sclerosis by open biopsy at another institution, who was then co...

journal_title：Brain tumor pathology

authors： Utsuki S,Oka H,Miyazaki T,Yamazaki T,Yasui Y,Fujii K,Kawano N,Tokuyama W,Iwabuchi K,Okayasu I,Yagishita S

更新日期：2010-04-01 00:00:00

abstract：:Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our stud...

journal_title：Brain tumor pathology

authors： Takada S,Hojo M,Takebe N,Tanigaki K,Miyamoto S

更新日期：2018-10-01 00:00:00

abstract：:A 55-year old female was referred to the Department of Neurosurgery, Kitasato Hospital, because of a hearing impairment. Neuroimaging revealed a typical meningioma attached to the falx in the right frontal region. During surgery, an encapsulated, circumscribed, reddish-gray, slightly hard tumor attached to the falx wa...

journal_title：Brain tumor pathology

authors： Miyajima Y,Oka H,Utsuki S,Hagiwara H,Inukai M,Kijima C,Hara A,Yasui Y,Kawano N,Fujii K

更新日期：2013-01-01 00:00:00

abstract：:The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. Genomic DNA and mRNA were extracted from frozen tissues of meningi...

journal_title：Brain tumor pathology

authors： Fukami S,Riemenschneider MJ,Kohno M,Steiger HJ

更新日期：2016-07-01 00:00:00

abstract：:A 43-year-old woman who had undergone breast cancer surgery 1 year previously complained of headache and nausea. Her brain computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a well-circumscribed, heterogeneously enhanced tumor in the right thalamus. She underwent gross total resection of the tum...

journal_title：Brain tumor pathology

authors： Akimoto J,Namatame H,Haraoka J,Kudo M

更新日期：2005-01-01 00:00:00

abstract：:The objective of this study is to clarify clinical significance of the H3F3A K27M mutation (H3K27M) and analyze the correlation between H3K27M, H3K27me3 status, and EZH2 expression and prognosis in spinal cord gliomas. Patients with spinal cord diffuse glioma regardless of World Health Organization (WHO) grade underwe...

journal_title：Brain tumor pathology

authors： Ishi Y,Takamiya S,Seki T,Yamazaki K,Hida K,Hatanaka KC,Ishida Y,Oda Y,Tanaka S,Yamaguchi S

更新日期：2020-07-01 00:00:00

abstract：:Wilms' tumour-1 (WT-1) protein m-RNA was recently demonstrated in meningiomas, suggesting the potential application of WT-1 immunotherapy in these tumours. The aim of the present study was to analyze the immunohistochemical expression of WT-1 protein, its correlation with the clinico-pathological variables and associa...

journal_title：Brain tumor pathology

authors： Barresi V,Caffo M,Branca G,Vitarelli E,Tuccari G

更新日期：2015-07-01 00:00:00

abstract：:Diffuse gliomas are highly infiltrative intracranial tumors, but there are few useful markers for detecting infiltrating glioma cells in the surrounding brain tissue. Doublecortin (DCX) is a microtubule-associated protein (MAP) that plays a crucial role in neuroblast migration. It was recently demonstrated that DCX is...

journal_title：Brain tumor pathology

authors： Masui K,Mawatari SY,Suzuki SO,Iwaki T

更新日期：2008-01-01 00:00:00

abstract：:The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for o...

journal_title：Brain tumor pathology

authors： Tamura M,Zama A,Kurihara H,Kano T,Imai H,Ishiuchi S,Iwai T,Naito I

更新日期：1997-01-01 00:00:00

abstract：:Intraoperative rapid diagnosis has been a useful neurosurgery tool for maximal resection and minimal morbidity. However, only a few studies have been conducted regarding diagnostic accuracy and associated problems. The present study reviews our experience in treating patients and investigates the accuracy and problems...

journal_title：Brain tumor pathology

authors： Uematsu Y,Owai Y,Okita R,Tanaka Y,Itakura T

更新日期：2007-01-01 00:00:00

abstract：:Chordomas and chondrosarcomas are two major malignant bone neoplasms located at the skull base. These tumors are rarely metastatic, but can be locally invasive and resistant to conventional chemotherapies and radiotherapies. Accordingly, therapeutic approaches for the treatment of these tumors can be difficult. Additi...

journal_title：Brain tumor pathology

authors： Kitamura Y,Sasaki H,Yoshida K

更新日期：2017-04-01 00:00:00

abstract：:Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to d...

journal_title：Brain tumor pathology

authors： Takahashi K,Tsuda M,Kanno H,Murata J,Mahabir R,Ishida Y,Kimura T,Tanino M,Nishihara H,Nagashima K,Tanaka S

更新日期：2014-04-01 00:00:00

abstract：:Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of anaplastic PXA has been proposed. The present case was a 59-year-old woman...

journal_title：Brain tumor pathology

authors： Asano K,Miyamoto S,Kubo O,Kikkukawa T,Yagihashi A,Ohkuma H

更新日期：2006-04-01 00:00:00

abstract：:The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstr...

journal_title：Brain tumor pathology

authors： Moriya J,Tanino MA,Takenami T,Endoh T,Urushido M,Kato Y,Wang L,Kimura T,Tsuda M,Nishihara H,Tanaka S,R-IHC Study Group.

更新日期：2016-01-01 00:00:00

abstract：:Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). This study was designed to determine whether ATRX status correlates with uptake of 11C-methionine in WHO grades II and III gliomas. Sixty-two patients underwent 11C-methionine positron e...

journal_title：Brain tumor pathology

authors： Ogishima T,Tamura K,Kobayashi D,Inaji M,Hayashi S,Tamura R,Nariai T,Ishii K,Maehara T

更新日期：2017-01-01 00:00:00

abstract：:Detection of mutations in the isocitrate dehydrogenase 1 (IDH1) gene is useful for accurate diagnosis of lower grade gliomas, as described in the 2016 World Health Organization classification of tumors of the central nervous system. Conventional analysis tools, including Sanger DNA sequencing and immunohistochemistry,...

journal_title：Brain tumor pathology

authors： Hirano M,Ohka F,Maeda S,Chalise L,Yamamichi A,Aoki K,Kato A,Tanahashi K,Motomura K,Nishimura Y,Hara M,Shinjo K,Kondo Y,Wakabayashi T,Natsume A

更新日期：2018-04-01 00:00:00

abstract：:Congenital malignant gliomas are rare brain tumors about which few reports have been published. We present the clinical course and genetic alterations in an infant with a congenital malignant glioma detected incidentally by ultrasonography at 36 weeks. The tumor occupied the right temporoparietal region, extended to t...

journal_title：Brain tumor pathology

authors： Yamashita S,Ryu S,Miyata S,Uchinokura S,Yokogami K,Uehara H,Moriguchi S,Iwakiri T,Marutsuka K,Ikenoue M,Sawa D,Yamada N,Kodama Y,Takeshima H

更新日期：2012-04-01 00:00:00

abstract：:We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and w...

journal_title：Brain tumor pathology

authors： Sakurada K,Akasaka M,Kuchiki H,Saino M,Mori W,Sato S,Nakazato Y,Kayama T

更新日期：2007-01-01 00:00:00