Abstract：
:This is the first report in the forensic literature of a combination of fatal digoxin poisoning with endocardial fibroelastosis (EFE). Typical morphological features of EFE as the cause of clinically diagnosed cardiomyopathy were present in the autopsy of a 3-year-old girl, including cardiac hypertrophy and marked thickening of the left-sided endocardium, consisting of numerous elastic and collagenic fibres. After exclusion of cardiac and cerebral causes of death, accidental digoxin intoxication was proved. Postmortem toxicological analyses by fluorescence polarization immunoassay (FPIA) disclosed digoxin levels of 71 micrograms/kg (femoral vein blood), 77 micrograms/kg (cardiac blood), 255 and 221 micrograms/kg (cardiac muscle of the right and left chamber), 163 micrograms/kg (psoas muscle), 91 micrograms/kg (lung), 222 micrograms/kg (liver) and 520 micrograms/kg (kidney). The results are compared with the antemortem digoxin concentration of 39 ng/ml serum. The case is discussed from its unusual morphological and toxicological aspects, with special consideration of possible medical malpractice.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Grellner W,Käferstein H,Sticht Gdoi
10.1016/s0379-0738(97)00134-5subject
Has Abstractpub_date
1997-10-06 00:00:00pages
211-6issue
3eissn
0379-0738issn
1872-6283pii
S0379073897001345journal_volume
89pub_type
杂志文章abstract：:In addition to the pelvis, cranium and phalanges, the sternum is also used for postmortem sex identification. Bone measurements may be obtained on cadaveric bones. Alternatively, computerized tomography may be used to obtain measurements close to the original ones. Moreover, usage of artificial neural networks (ANNs) ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.05.011
更新日期：2019-08-01 00:00:00
abstract：:The authors describe the most popular drugs and their substitutes being used in Poland. The paper also presents the problem of developing and examining criminalistic traces in biological and some non-organic materials. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90150-w
更新日期：1990-05-01 00:00:00
abstract：:This study determines the development rates of the immature stages of the fly Ophyra albuquerquei Lopes, 1985. In this study, with 70% relative humidity and a 12-h photophase, eggs, larvae, and pupae were kept in a biochemical oxygen demand chamber at temperatures of 10, 15, 17, 20, 22, 25, 27, 30, 33, 35, and 40°C. W...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.07.014
更新日期：2015-09-01 00:00:00
abstract：:A high-performance liquid chromatography-tandem mass spectrometry (LC/MS/MS) technique was developed for the simultaneous determination of five non-steroidal anti-inflammatory oxicam drugs (ampiroxicam, tenoxicam, piroxicam, meloxicam and lornoxicam) in human plasma. These five oxicam drugs and isoxicam (internal stan...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.11.016
更新日期：2013-04-10 00:00:00
abstract：OBJECTIVES:To describe the frequency of genital and anal injury and associated demographic and assault characteristics in women alleging sexual assault. DESIGN:Cross-sectional study. SETTING:Sexual Assault Resource Centre (SARC), Western Australia. PARTICIPANTS:Total of 1266 women attending SARC from Jan-2009 to Mar...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.03.013
更新日期：2017-06-01 00:00:00
abstract：:Conclusive evidence was obtained in this study that immunoelectrophoresis could be used in the identification of blood-stains in two particular cases: for diagnosis or approach to diagnosis of the age of a blood-stain, and for diagnosis of the human origin of a blood-stain that had been treated with petroleum products...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(78)90025-7
更新日期：1978-09-01 00:00:00
abstract：:Fingerprint detection and Short Tandem Repeat (STR) typing are two approaches used for identification of individuals. The main goal of forensic laboratories is the development of a standardized protocol to obtain an STR profile from latent fingerprints, by typing the DNA transferred onto touched objects. The results o...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.109905
更新日期：2019-09-01 00:00:00
abstract：:In this study, the use of benchtop NMR spectroscopy in the analysis of solids and liquids used and/or produced during the HI reduction of pseudoephedrine was evaluated. The study focused on identifying organic precursors and phosphorus containing compounds used in and/or produced during the manufacturing process. Samp...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.06.026
更新日期：2017-09-01 00:00:00
abstract：:Doxylamine is an antihistamine of the ethanolamine class. It is used primarily as a sleep-inducing agent. Only a few reports can be found in the literature about lethal intoxications with doxylamine, but many with combined intoxications. Doxylamine is, aside from diphenhydramine, the only chemically defined active ing...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/s0379-0738(00)00393-5
更新日期：2001-06-01 00:00:00
abstract：:A new discrimination method for the bioapatite materials bone, antler and ivory was developed using X-ray diffractometry and comprises non-invasive measurements in order to take valuable objects into account. Our approach deals with the analysis of peak intensity ratios resulting from several measurements on each obje...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110159
更新日期：2020-03-01 00:00:00
abstract：:Testing human hair for drugs of abuse is a relatively new technique which requires control before being fully accepted in justice applications. Laboratories must be able to demonstrate that they can accurately determine what drugs are present in unknown hair samples and at what levels. To date few exercises have been ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(96)02058-0
更新日期：1997-01-17 00:00:00
abstract：:Cyanoacrylate fuming, rhodamine 6G staining and 532 nm laser light visualization were used to reveal a thirty-year-old fingermark on a plastic bag discovered at a double homicide scene. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.04.025
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Studies testing the Willems method of age estimation with gender-specific scores on different population groups have reported consistently more accurate results over other methods. Not enough is known about the validity of Willems non-gender specific scores. AIM:The present study aimed to compare the accura...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.05.012
更新日期：2016-09-01 00:00:00
abstract：:Chemicals associated with clandestine drug laboratories are often disposed of covertly into soil, sewerage systems, or public waste management facilities. There are two significant issues relating to such dumps of materials; they might contain valuable evidence as to drug manufacture, and they might be a source of pol...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00110-5
更新日期：2003-06-24 00:00:00
abstract：INTRODUCTION:Cadaver dogs are known as valuable forensic tools in crime scene investigations. Scientific research attempting to verify their value is largely lacking, specifically for scents associated with the early postmortem interval. The aim of our investigation was the comparative evaluation of the reliability, ac...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.02.031
更新日期：2008-01-15 00:00:00
abstract：:Researchers in the field of hair analysis have known for at least two decades that test results for many chemical compounds remain positive for a considerable period of time after subjects have reported cessation of use. These findings were generally based on small sample populations or individual case studies. Within...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.06.030
更新日期：2015-09-01 00:00:00
abstract：:In this study, we report the chemical analyses of various non-pathological, tuberculosis and syphilis infected bone samples from different burial environments by Fourier transform infrared spectroscopy (FT-IR), in the framework of a general study of diagenesis. Dating human skeletal remains is one of the most importan...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.05.008
更新日期：2008-02-25 00:00:00
abstract：:Short tandem repeats (STRs) or microsatellites have been recognized worldwide as a powerful tool for human identification. They have become widely used in human identification especially in criminal cases and mass disasters. Police departments are often interested in cases where tissues are already decomposed and only...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.09.052
更新日期：2004-12-02 00:00:00
abstract：:In the last two years, an epidemic of fatal narcotic overdose cases has occurred in the Tampa area of Florida. Fourteen of these deaths involved fentanyl and/or the new designer drug, acetyl fentanyl. Victim demographics, case histories, toxicology findings and causes and manners of death, as well as, disposition of f...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.10.021
更新日期：2015-12-01 00:00:00
abstract：:In an investigation of postmortem ethanol diffusion deuterium-labeled ethanol-d6 was instilled by peroral gavage immediately after death by CO into the stomach of rat carcasses which were subsequently kept for 12-72 h at 5 or 30 degrees C. The heart blood, abdominal fluid and several tissues were collected and analyze...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(95)01820-4
更新日期：1995-12-29 00:00:00
abstract：:The importance of temperature data in minimum postmortem interval (minPMI) estimations in criminal investigations is well known. To maximise the accuracy of minPMI estimations, it is imperative to investigate the different components involved in temperature modelling, such as the duration of temperature data logger pl...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.110028
更新日期：2020-01-01 00:00:00
abstract：:A collaborative study on Raman spectroscopy and microspectrophotometry (MSP) was carried out by members of the ENFSI (European Network of Forensic Science Institutes) European Fibres Group (EFG) on different dyed cotton fabrics. The detection limits of the two methods were tested on two cotton sets with a dye concentr...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.05.025
更新日期：2012-10-10 00:00:00
abstract：:Direct detection of amphetamine type stimulants (ATSs) including methylamphetamine (MA) in street samples and biological matrices without the need for pretreatment or extraction is a great challenge for forensic drug analysis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools for ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.02.048
更新日期：2016-07-01 00:00:00
abstract：:A portable near infrared spectrometer was applied to the presumptive identification of psychotropic drugs based on library searching. Data-treatment methods (mathematical pretreatment and library search algorithm) were examined on the basis of differentiation ability. The optimized mathematical pretreatment was a stan...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.05.020
更新日期：2014-09-01 00:00:00
abstract：:The aim of the present study was to investigate stress gene expression in cultured primary fibroblasts established from Achilles tendons collected during autopsies from sudden infant death syndrome (SIDS) cases, and age-matched controls (infants dying in a traumatic event). Expression of 4 stress responsive genes, HSP...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.06.003
更新日期：2013-10-10 00:00:00
abstract：:The effect of population subdivision on the determination of kinship of any two persons is investigated in this paper. Expressions of the joint genotype probabilities and likelihood ratios on kinship testing are reported. Two real cases are analysed using the Hong Kong Chinese population data and the Spanish data. Var...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00168-3
更新日期：2003-08-12 00:00:00
abstract：:In forensics and archaeology, it is important to distinguish human from animal remains and to identify animal species from fragmentary bones and bloodstains. We report blind tests in which a protein radioimmunoassay (pRIA) was used to identify the species of six bone fragments lacking morphological specificity and 43 ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.08.007
更新日期：2006-06-02 00:00:00
abstract：:Recently, modern cross-sectional imaging techniques such as multi-detector computed tomography (MDCT) have pioneered post mortem investigations, especially in forensic medicine. Such approaches can also be used to investigate bones non-invasively for anthropological purposes. Long bones are often examined in forensic ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.10.029
更新日期：2013-02-10 00:00:00
abstract：:In a study of the incidence of suicide in jails and prisons under increasing conditions of deprivation in Italy from 2004 to 2008, imprisonment involving greater levels of isolation was found to be associated with a higher rate of suicide. Greater care should be taken to ensure that prisoners in isolation do not commi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.08.016
更新日期：2013-12-10 00:00:00
abstract：:A urine screening in fatalities with an unnatural or unknown cause of death (13-40 years of age) was carried out to evaluate the proportion of undetected drug-related cases. Ten out of 160 fatalities without a hint of drug consumption were classified as drug-related according to the definition of the Bundeskriminalamt...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90062-f
更新日期：1993-11-01 00:00:00
