Cross-reaction patterns in patients with contact allergy to simple methylol phenols.

Abstract:

:The low-molecular-weight phenols 2-methylol phenol (2-MP), 4-methylol phenol (4-MP), 2,4,6-trimethylol phenol (2,4,6-MP), 3-methylol phenol (3-MP), 2,4-dimethylol phenol (2,4-MP), and 2,6-dimethylol phenol (2,6-MP) are contact sensitizers in resins based on phenol and formaldehyde (P-F-R). Other chemically related low-molecular-weight phenols are common in the environment. In patients hypersensitive to P-F-R and MPs, it is for diagnostic, therapeutic and preventive reasons necessary to know their cross-reaction patterns, which this study was therefore designed to investigate. In patients with contact allergy to a P-F-R and at least 1 MP, additional patch testing was performed with 6 MPs and 13 chemically related compounds. The 19 substances were tested at equimolar concentrations and in serial dilutions. Investigations by high-performance liquid chromatography were carried out to exclude contamination as the cause of the patch test reactions. Probable cross-reacting substances were o-cresol, p-cresol, salicylaldehyde, 2,4-dimethyl phenol, and 2,6-dimethyl phenol.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Bruze M,Zimerson E

doi

10.1111/j.1600-0536.1997.tb00044.x

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

82-6

issue

2

eissn

0105-1873

issn

1600-0536

journal_volume

37

pub_type

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