Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention.

Abstract:

BACKGROUND:The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy. OBJECTIVES:To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions. PATIENTS/METHODS:The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl K 400 1.5% in pet. RESULTS:A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 (P < 0.001). CONCLUSIONS:Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Johansen JD,Veien N,Laurberg G,Avnstorp C,Kaaber K,Andersen KE,Paulsen E,Sommerlund M,Thormann J,Nielsen NH,Vissing S,Kristensen O,Kristensen B,Agner T,Menné T

doi

10.1111/j.1600-0536.2008.01364.x

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

48-51

issue

1

eissn

0105-1873

issn

1600-0536

pii

COD1364

journal_volume

59

pub_type

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