Abstract:
:Although p-phenylenediamine (PPD) has been recognized as an extreme sensitizer for many years, the exact mechanism of sensitization has not been elucidated yet. Penetration and the ability to bind to proteins are the first two hurdles that an allergen has to overcome to be able to sensitize. This review is an overview of studies regarding PPD penetration through skin (analogues) and studies on the amino acids that are targeted by PPD. To complete this review, the auto-oxidation and N-acetylation steps involved in PPD metabolism are described. In summary, under normal hair dyeing exposure conditions, <1% of the applied PPD dose penetrates the skin. The majority (>80%) of PPD that penetrates will be converted into the detoxification products monoacetyl-PPD and diacetyl-PPD by the N-acetyltransferase enzymes. The small amount of PPD that does not become N-acetylated is susceptible to auto-oxidation reactions, yielding protein-reactive PPD derivatives. These derivatives may bind to specific amino acids, and some of the formed adducts might be the complexes responsible for sensitization. However, true in vivo evidence is lacking, and further research to unravel the definite mechanism of sensitization is needed.
journal_name
Contact Dermatitisjournal_title
Contact dermatitisauthors
Pot LM,Scheitza SM,Coenraads PJ,Blömeke Bdoi
10.1111/cod.12032subject
Has Abstractpub_date
2013-04-01 00:00:00pages
193-207issue
4eissn
0105-1873issn
1600-0536journal_volume
68pub_type
杂志文章,评审abstract:BACKGROUND:The use of permanent hair dyes exposes hairdressers to contact allergens such as p-phenylenediamine (PPD), and the preventive measures are insufficient. OBJECTIVES:To perform an in vivo test to study the protective effect of gloves commonly used by hairdressers. PATIENTS/MATERIALS/METHODS:Six gloves from S...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12320
更新日期:2015-04-01 00:00:00
abstract::Fragrance substances represent a very diverse group of chemicals; a proportion of them are associated with the ability to cause allergic reactions in the skin. Efforts to find substitute materials are hindered by the need to undertake animal testing for determining both skin sensitization hazard and potency. One strat...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.0105-1873.2004.00322.x
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Wheat protein and its derivatives can cause protein contact dermatitis (PCD), which mainly occurs in bakers. Few studies have attempted to identify the allergens responsible for wheat PCD. OBJECTIVES:The aim of this study was to identify allergenic wheat proteins in patients with wheat PCD. METHODS:Water-s...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2010.01741.x
更新日期:2010-07-01 00:00:00
abstract::The purpose of the present study was to compare the frequency of lanolin allergy during two periods and to assess the adequacy of testing with one standard allergen. Among 1230 consecutive patients with eczema who were standard patch tested, 33 (2.7%), 21 females and 12 males, gave a positive reaction to wool alcohols...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1979.tb04824.x
更新日期:1979-05-01 00:00:00
abstract::Common emulsifiers were tested in over 1,200 patients with eczema. Triethanolamine stearate tested at 5% in petrolatum caused irritant reactions in 9.5% of the patients. On the other hand, non-ionic emulsifying agents tested at 10-20% produced irritation in only a few cases. Allergic reactions were found in 2.1% of th...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1976.tb03027.x
更新日期:1976-08-01 00:00:00
abstract::We studied 39 patients with erythema-dyschromicum-perstans-like dermatitis seen at Changuinola Hospital in Panama. They were compared with 41 controls. The 2 groups were native field workers of the banana plantations exposed to many pesticides. In 34 patients, there was a positive patch test reaction to 2,4,5,6-1,3-te...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1996.tb02360.x
更新日期:1996-10-01 00:00:00
abstract::Nickel is used in coins because the metal has beneficial properties, including price, colour, weight, and corrosion resistance, and also because it is easy to stamp. It has often been claimed that the duration of skin contact with coins is too short to cause nickel release and dermatitis. However, it is well known by ...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0536.2012.02127.x
更新日期:2013-01-01 00:00:00
abstract:UNLABELLED:BACKGROUND. Allergens included in the European baseline series should result in positive patch test reactions in at least 1% of a patch test population. Inclusion of local anaesthetics other than benzocaine in the baseline series has previously been debated. OBJECTIVES:To investigate temporal trends of benz...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2010.01858.x
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Reviews on irritant and allergic airborne contact dermatitis have been previously reported in the literature. MATERIALS AND METHODS:Here, we present an update based on recently published airborne-induced skin reactions. For this survey, we screened the journals Contact Dermatitis, Dermatitis, and included r...
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/cod.12022
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Lavender is commonly used in aromatherapy and in a broad range of personal and household products. It has been identified as a contact sensitizer, and has been reported to cause allergic contact dermatitis (ACD). OBJECTIVES:To report our experience with contact allergy and ACD caused by lavender, and to rai...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.13247
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Neurosensory irritation is a subjective phenomenon induced by a number of chemicals. Objectives. To investigate the sensory irritation induced by two organic solvents - n-octane and cumene - between two groups of volunteers, stingers and non-stingers, identified as such according to the results of a lactic a...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2011.01938.x
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:The proper reading of patch test (PT) reactions, based on morphological criteria, is of utmost importance. Digital images are increasingly used for medical training. OBJECTIVES:To assess the diagnostic validity of readings of 20 digital images of various PT reaction grades by congress attendants. METHODS:1...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2007.01236.x
更新日期:2007-11-01 00:00:00
abstract::According to some reports in the literature, the hormonal fluctuations which occur during the menstrual cycle may affect the clinical expression of contact allergy to a greater or lesser degree. In clinical practice, too, patient history often shows exacerbation of the contact dermatitis during the days immediately pr...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.0105-1873.2005.00588.x
更新日期:2005-06-01 00:00:00
abstract::The occurrence of occupational contact dermatitis among workers in a rubber factory from 1976 to 1980 was studied. Insurance compensation was paid to 50 workers with dermatitis. 21 of the cases were allergic and 27 toxic contact dermatitis, giving a contact dermatitis frequency of 5.6/1000 workers. Paraphenylenediamin...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1982.tb04259.x
更新日期:1982-11-01 00:00:00
abstract::Serious adverse skin reactions to permanent hair dyes and temporary black tattoos have been reported. As temporary tattoos have become fashionable among adolescents, the risk profile for p-phenylenediamine (PPD) sensitization of the population has changed simultaneously with an increasing use of hair dyes in this age ...
journal_title:Contact dermatitis
pub_type: 杂志文章,多中心研究
doi:10.1111/j.0105-1873.2006.00746.x
更新日期:2006-02-01 00:00:00
abstract::Hand dermatitis is a prevalent disease with an episodic, chronic character. The use of medical resources is high and is often related to reduced (work) functioning. The burden is therefore high for patients and society. Management of hand dermatitis is often unsatisfactory, and for this reason prevention is important....
journal_title:Contact dermatitis
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0536.2010.01825.x
更新日期:2011-02-01 00:00:00
abstract::Risk factors for cement eczema were studied among workers employed in the Danish construction industry. 2 cohorts exposed to cement containing different concentrations of water-soluble chromate were examined. A statistically significant decrease in the number of workers with allergic cement eczema was found in the coh...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1991.tb01793.x
更新日期:1991-08-01 00:00:00
abstract::Effects of test techniques on neomycin patch test results have not been thoroughly investigated. This study focuses on effects of dose and application time of neomycin sulfate patch tests on test results. The effects are assessed both visually and by perfusion. 16 subjects positive to neomycin are retested with neomyc...
journal_title:Contact dermatitis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1600-0536.2000.043005283.x
更新日期:2000-11-01 00:00:00
abstract::In this study, 333 nurses, 92 dentists and 167 doctors were investigated. Most positive patch tests obtained were unrelated to occupation. Nurses were most often sensitized to penicillins and, of the disinfectants, formaldehyde was the commonest cause of occupational dermatitis. Among dentists, the most common occupat...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1989.tb03140.x
更新日期:1989-04-01 00:00:00
abstract::In this study, the applicability of a symptom-based questionnaire on hand dermatitis was assessed in a population of rubber workers. The questionnaire was previously validated in a study among nurses. 224 subjects employed in 9 different companies completed a questionnaire on skin complaints. Subsequently, 202 workers...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1034/j.1600-0536.2000.042004202.x
更新日期:2000-04-01 00:00:00
abstract::During a 5-year period, 3664 consecutive patients were patch tested in a private dermatology practice with the Standard Series of the International Contact Dermatitis Research Group (ICDRG). 454 of these were tested with one or more additional substances which were suspected of having caused their dermatitis. 194 of t...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1983.tb04396.x
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Thiurams and dithiocarbamates are structurally related sensitizing rubber accelerators. OBJECTIVES:To study patterns of simultaneous patch test reactions to thiurams and dithiocarbamates at the Finnish Institute of Occupational Health in 1991-2015. METHODS:We searched the patch test files for patients with...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12687
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The prevalence of p-phenylenediamine (PPD) sensitization is 4% in the patch tested population and varies between zero and 1.5% in the general population. Hair dye is a recognised sensitization source. OBJECTIVES:To define the prevalence rates of PPD sensitization in the general and patch tested populations ...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/cod.12354
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Occlusion of the skin is a risk factor for development of irritant contact dermatitis. Occlusion may, however, have a positive effect on skin healing. No consensus on the effect of occlusion has been reached. OBJECTIVES:To investigate skin barrier response to occlusion on intact and damaged skin. METHODS:I...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.2010.01773.x
更新日期:2010-12-01 00:00:00
abstract::Allergens used for patch testing in the hairdressing series vary between dermatology centres in the UK. The aim of our study is to ascertain the hairdressing allergens currently in use and their test results in several dermatology centres in the UK. Data were obtained from databases in 9 dermatology departments. The a...
journal_title:Contact dermatitis
pub_type: 杂志文章,多中心研究
doi:10.1111/j.0105-1873.2005.00661.x
更新日期:2005-09-01 00:00:00
abstract::This is a study of occupational skin disease among military personnel and conscripts in Singapore. All military personnel and conscripts diagnosed with occupational dermatoses in the National Skin Centre, Singapore, between 1989-1999 were studied retrospectively. Conscripts and regulars comprised 7.3% of all occupatio...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1034/j.1600-0536.2001.440206.x
更新日期:2001-02-01 00:00:00
abstract::2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) is an azo compound which has been used as a radical chain initiator. The purpose of this study was to confirm contact sensitivity to AAPH in individuals who were engaged in the production of AAPH, and presented with prolonged eczematous eruptions mainly on exposed a...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1998.tb05803.x
更新日期:1998-07-01 00:00:00
abstract::During the 2-year period 1976--1977, seven patients were studied with primary irritant dermatitis from topical preparations containing clioquinol. During the same period contact hypersensitivity to the compound was recorded in 35 eczema patients. Six of the seven patients with clioquinol irritancy had used creams cont...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1979.tb04810.x
更新日期:1979-03-01 00:00:00
abstract::An outbreak of occupational dermatitis in a rubber tyre factory is reported. An unusual clinical picture was recognized. Patch tests revealed a high sensitization rate to the MBT derivative used: 2-(2'-4'dinitrophenylthio)benzothiazole. Since tests with MBT mix and dinitrophenol were negative; sensitization to a conta...
journal_title:Contact dermatitis
pub_type: 杂志文章
doi:10.1111/j.1600-0536.1987.tb02637.x
更新日期:1987-07-01 00:00:00
abstract::Between 1995 and 1999, 1986 patients were tested in the 31 participating centres of the Information Network of Departments of Dermatology (IVDK), all of them members of the German Contact Dermatitis Research Group, with a textile dyes series containing Disperse Blue (DB) 106 and 124, and since 1997 also with a mix of ...
journal_title:Contact dermatitis
pub_type: 杂志文章,多中心研究
doi:10.1034/j.1600-0536.2001.044003173.x
更新日期:2001-03-01 00:00:00