Contact dermatitis due to 2,2'-azobis(2-amidinopropane) dihydrochloride: an outbreak in production workers.

Abstract:

:2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) is an azo compound which has been used as a radical chain initiator. The purpose of this study was to confirm contact sensitivity to AAPH in individuals who were engaged in the production of AAPH, and presented with prolonged eczematous eruptions mainly on exposed areas. Patch testing was carried out with AAPH (1 and 5% aq.) on 8 patients and 6 healthy volunteers who had never been exposed to this chemical. All patients showed a strong positive patch test reaction to this agent, while all control subjects showed negative results. Because this chemical has recently been used for studies on the oxidation of biological materials, not only production workers in the chemical industry but also medical researchers should avoid prolonged exposure to this agent.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Takiwaki H,Arase S,Nakayama H

doi

10.1111/j.1600-0536.1998.tb05803.x

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

4-7

issue

1

eissn

0105-1873

issn

1600-0536

journal_volume

39

pub_type

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