UVB serum factor: suppression of allergic contact dermatitis in guinea pigs.

Abstract:

:Serum from guinea pigs exposed to a single high dose of UVB and from controls was injected into the spleen of normal animals 5 days prior to sensitization. When 1.0 ml was transferred 4.5 h after irradiation, immunosuppression was obtained. Transfer of 1.5 ml of serum 2.5 h after irradiation failed to induce immunosuppression. This experimental model in guinea pigs might be valuable in further studies investigating the effect of other modalities of ultraviolet exposure (e.g., PUVA or high-dose UVA) on the release of soluble serum factor(s) inducing immunosuppression in allergic contact dermatitis.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Christensen OB,Christensen MB,Wall LM

doi

10.1111/j.1600-0536.1987.tb01426.x

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

208-11

issue

4

eissn

0105-1873

issn

1600-0536

journal_volume

16

pub_type

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