Generalized reactions during skin testing with clindamycin in drug hypersensitivity: a report of 3 cases and review of the literature.

Abstract:

BACKGROUND:The diagnostic approach to drug hypersensitivity includes a detailed medical history, clinical examination, and skin testing and/or oral challenge with a culprit or alternative drug, depending on the type of reaction and the suspected drugs. Although skin testing is considered to be rather safe, cutaneous and systemic, including fatal, reactions have been described. OBJECTIVES:To report 3 cases with generalized delayed reactions after skin testing with clindamycin, and to review the existing literature. METHODS:Thorough clinical examination, blood tests and prick, intradermal and patch tests were performed in 3 patients. RESULTS:All patients experienced generalized maculopapular exanthema after intradermal and patch testing with clindamycin and amoxicillin in the first patient, and clindamycin alone in the second and third patient. None of the patients showed immediate reactions to skin tests, while positive intradermal reactions after 24 h to amoxicillin and clindamycin were observed in the first patient, and positive intradermal reactions after 24 h to clindamycin were observed in the second and third patients. CONCLUSIONS:Skin testing with clindamycin in the diagnosis of drug hypersensitivity carries some risk of adverse reactions. A stepwise and individual diagnostic work-up, considering potential risk factors, and testing in a specialized centre with emergency equipment available is highly recommended.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Papakonstantinou E,Müller S,Röhrbein JH,Wieczorek D,Kapp A,Jakob T,Wedi B

doi

10.1111/cod.12956

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

274-280

issue

4

eissn

0105-1873

issn

1600-0536

journal_volume

78

pub_type

杂志文章,评审
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    authors: de Wit FS,de Groot AC,Weyland JW,Bos JD

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  • Nickel allergy--prevalence in a population of Swedish youths from patch test and questionnaire data.

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    更新日期:2008-02-01 00:00:00

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    pub_type: 杂志文章

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