Abstract:
:An opaque screen moving overhead provokes an escape response in the crab Chasmagnathus granulatus that habituates after a few presentations of the eliciting stimulus. Fifteen trials with a 180-s intertrial interval or 30 trials with a 90-s interval (strong training protocol) ensures long-term habituation (LTH) of the response for 24 h, whereas 10 trials (weak training protocol) fail to induce it. However, robust LTH is obtained when crabs are injected with human angiotensin (All; 50 pmol) immediately after a weak training protocol. This memory-enhancing effect of All is dose-dependent, reversible by saralasin (5 pmol), and vanishes either when the weak training protocol is reduced to only five trials, or when the peptide is given before training or 1 h after. LTH is impaired by saralasin (5 pmol) administered before or after the strong training protocol, but no amnestic effect is disclosed when the antagonist is given 1 h after. On the other hand, both All-like immunoreactivity and angiotensin-converting enzyme-like activity are described in diverse tissues of Chasmagnathus, namely, in gills and in both thoracic and supraesophageal ganglia. Results support the view that some components of the renin-angiotensin system and their influence on memory might have emerged early in evolution.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Delorenzi A,Pedreira ME,Romano A,Garcia SI,Pirola CJ,Nahmod VE,Maldonado Hdoi
10.1016/s0361-9230(96)00178-5subject
Has Abstractpub_date
1996-01-01 00:00:00pages
211-20issue
4eissn
0361-9230issn
1873-2747pii
S0361-9230(96)00178-5journal_volume
41pub_type
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journal_title:Brain research bulletin
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