Abstract:
:The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.
journal_name
Naturejournal_title
Natureauthors
Russo AA,Jeffrey PD,Patten AK,Massagué J,Pavletich NPdoi
10.1038/382325a0subject
Has Abstractpub_date
1996-07-25 00:00:00pages
325-31issue
6589eissn
0028-0836issn
1476-4687journal_volume
382pub_type
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