Functional domains of S-type pyocins deduced from chimeric molecules.

Abstract:

:Functional domain structures of pyocins AP41, S1, and S2 were assigned by examining the functions of chimeric pyocins and deletion derivatives. Pyocins AP41, S1, and S2 are essentially composed of three domains, the receptor-binding domain, the translocation domain, and the DNase domain, in that order from the N terminus to the C terminus. The alignment of these domains is distinct from that in E2-group colicins with functions similar to those of these pyocins. Pyocins AP41 and S2 have a fourth domain between the receptor-binding and the translocation domains, which is dispensable for their killing functions.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Sano Y,Kobayashi M,Kageyama M

doi

10.1128/jb.175.19.6179-6185.1993

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

6179-85

issue

19

eissn

0021-9193

issn

1098-5530

journal_volume

175

pub_type

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