Colcemid sensitivity of fission yeast: permeability and detoxification properties of resistant mutants.

Abstract:

:Mutants of Schizosaccharomyces pombe, which were resistant to concentrations of colcemid inhibitory to the wild-type parent, were not diminished in their permeability to colcemid or colchicine. They also did not modify colcemid to a detectable derivative or to a product that was incapable of binding to brain tubulin. The resistance of these mutants was therefore via mechanisms different from those of permeability and detoxification known for animal cells.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Lederberg S,Gourse RL,Sackett DL

doi

10.1128/JB.129.1.198-201.1977

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

198-201

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

129

pub_type

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