Immunocytochemical localization of blood group ABH antigens in the human parotid gland.

Abstract:

:The aim of this study was to determine whether the parotid gland, like other salivary glands, produces blood group antigens. A post-embedding immunogold staining (IGS) method for ABH antigens was applied to osmicated and nonosmicated, routinely prepared specimens of normal human parotid glands. A and B antigens were not detected, whereas H antigen was found in acini and ducts of glands from A, B, and O subjects. In osmicated samples, the only sites of H labeling were secretory granules of a few acinar cells and those of most intercalated duct cells. In both cell types, only the pale matrix of the granules was stained. In non-osmicated samples, secretory granules showed the same distribution pattern of H, although gold particles were more abundant, and basolateral membranes of acinar and striated duct cells and the apical vesicles of striated duct cells were also labeled. Our results suggest that small amounts of H antigen are secreted by the parotid gland.

journal_name

J Dent Res

authors

Lantini MS,Cossu M

doi

10.1177/00220345940730021101

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

556-60

issue

2

eissn

0022-0345

issn

1544-0591

journal_volume

73

pub_type

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