Bone resorbing activity of surface-associated material from Actinobacillus actinomycetemcomitans and Eikenella corrodens.

Abstract:

:The results of this study demonstrate that saline extracted surface-associated material (SAM) of Actinobacillus actinomycetemcomitans and Eikenella corrodens stimulates bone resorption at picomolar concentrations. Various inhibitors of known osteolytic mediators--indomethacin, interleukin-1 receptor antagonist (IL-1ra) and a neutralising antibody to murine tumour necrosis factor (TNF) alpha--were tested to determine the mechanism of action of these SAMs. Bone resorption induced by SAM from E. corrodens was slightly inhibited by indomethacin and almost completely inhibited by blocking the action of TNF alpha; that from A. actinomycetemcomitans was not significantly affected by either of these inhibitors.

journal_name

J Med Microbiol

authors

Meghji S,Wilson M,Barber P,Henderson B

doi

10.1099/00222615-41-3-197

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

197-203

issue

3

eissn

0022-2615

issn

1473-5644

journal_volume

41

pub_type

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