DNA identification of the pathogen of candidal aspiration pneumonia induced in the course of oral cancer therapy.

Abstract:

:Aspiration of oropharyngeal bacteria and fungi is occasionally suspected in patients with pneumonia. A patient with oral carcinoma underwent chemoradioimmunotherapy and, about 4 weeks from the start of the therapy, the patient suffered from severe oral mucositis induced by chemoradiotherapy, and candidal pneumonia was subsequently induced. The candidal pneumonia was insufficiently improved by potent antifungal drugs, taking a lethal course. Randomly amplified polymorphic DNA analysis and DNA sequence examination of strains isolated from the oral cavity 1 week before the onset of pneumonia and autopsied lung revealed the identity of both strains as Candida albicans, and the DNA analysis supported aspiration of oral Candida. These results indicate that the pathogen of the pneumonia, C. albicans, was aspirated from the oral cavity and that oral Candida is easily aspirated and becomes the pathogen of pneumonia.

journal_name

J Med Microbiol

authors

Yamamoto T,Ueta E,Kamatani T,Osaki T

doi

10.1099/jmm.0.45769-0

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

493-496

issue

Pt 5

eissn

0022-2615

issn

1473-5644

journal_volume

54

pub_type

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