Abstract:
:The mdx mouse has been used as an animal model for human Duchenne muscular dystrophy (DMD). Unlike DMD, skeletal muscles of mdx mice undergo successful regeneration and do not show extensive fibrosis and functional impairment. Growth factors have been proposed to be involved in muscle growth and regeneration. We compared mitogenic activity for skeletal myoblasts released after injury in mdx and control mice, using crushed muscle extract (CME) as a model system. We found that CMEs from normal and mdx mice contained similar mitogenic activities per microgram protein, and produced similar maximal levels of mitogenic stimulation. Skeletal muscles from mdx mice, however, released higher amounts of CME protein per gram of muscle weight compared to controls, possibly as a result of histological or physiological alterations in mdx muscle tissue. Adequate mitogenic activity in CME from mdx muscles may be related to successful muscle regeneration in mdx mice.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Chen G,Bressler BH,Quinn LSdoi
10.1006/cbir.1994.1068subject
Has Abstractpub_date
1994-04-01 00:00:00pages
229-35issue
4eissn
1065-6995issn
1095-8355pii
S1065-6995(84)71068-7journal_volume
18pub_type
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