Abstract：
:Two studies examined the abuse potential of the N-methyl-D-aspartate (NMDA) non-competitive antagonist eliprodil [(+/-)-alpha-(4-chlorophenyl)-4-[(fluorophenyl)methyl]-1- piperidineethanol] by evaluating its reinforcing effects in rhesus monkeys and its phencyclidine (PCP)-like discriminative stimulus effects in rats. The monkeys were trained to self-administer PCP i.v. under a fixed ratio 10 schedule of reinforcement. After the monkeys were trained, saline, vehicle and various doses of eliprodil were substituted for PCP. The rats were trained to discriminate 3 micrograms/kg PCP from saline using a standard two-lever discrimination procedure with correct-lever responding reinforced under a fixed ratio 10 schedule of food reinforcement. After acquiring the discrimination, the rats were tested with various doses of PCP, dizocilpine and eliprodil. The self-administration study showed that eliprodil did not have reinforcing effects, since it maintained injection rates comparable to the negative controls, saline and vehicle. In the discrimination study it was found that the higher doses of PCP and dizocilpine resulted in 100% PCP-associated lever responding, whereas eliprodil occasioned no responding on the PCP-associated lever. The results from these studies suggest that eliprodil has a low potential for abuse in humans as well as providing further evidence that eliprodil produces a profile of behavioral effects unlike the PCP-site selective NMDA antagonists.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Balster RL,Nicholson KL,Sanger DJdoi
10.1016/0376-8716(94)90076-0subject
Has Abstractpub_date
1994-06-01 00:00:00pages
211-6issue
3eissn
0376-8716issn
1879-0046pii
0376-8716(94)90076-0journal_volume
35pub_type
杂志文章abstract：OBJECTIVE:To characterize patterns and correlates of inhalant use among incarcerated youth. METHOD:Residents (N=723) of 27 Missouri Division of Youth Services facilities completed interviews assessing substance use, psychiatric symptoms, antisocial traits, trauma, suicidality, and criminality. RESULTS:Participants av...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.08.023
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:North Carolina, like much of the U.S. South, is disproportionately affected by HIV and hepatitis. This persistently high disease burden may be driven in part by laws that criminalize the possession and distribution of syringes for illicit drug use. Legal change to decriminalize syringes may reduce infection ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.08.007
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To examine the characteristics of "diagnostic orphans" among cannabis users - those who report one or two symptoms of DSM-IV dependence but do not meet diagnostic criteria for DSM-IV abuse or dependence - 4 years post-assessment. METHOD:Data were collected from a representative population cohort of young Aus...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.07.003
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Anecdotal evidence suggests consumers of caffeine self-administer strategies to reduce consumption, but little is known of what these strategies are or how they are implemented. This study aimed to understand the lived experience of reducing caffeine consumption including specific techniques (what) and imple...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108024
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:Examined effects of prenatal cocaine exposure (PCE) on tobacco, alcohol, marijuana and cocaine use by age 15. METHODS:Adolescent (n=358; 183 PCE, 175 non-prenatally cocaine exposed; NCE) drug use was assessed using urine, hair, and/or blood spot samples and self-report (Youth Risk Behavior Surveillance Syste...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.09.031
更新日期：2014-01-01 00:00:00
abstract：:This paper examines official published statistics for various causes of death in the United Kingdom between 1970 and 1985. The variables selected were mainly those that had been linked to alcohol or cigarette use. In particular, changes in mortality due to acute myocardial infarction, cancer of trachea, bronchus and l...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(89)90079-3
更新日期：1989-10-01 00:00:00
abstract：:Opioid receptors are critical therapeutic targets for medications development relevant to the treatment of drug dependence and pain. With recent advances in molecular neurobiology, it has become evident that the functional activity of opioid receptors, as ligand-regulated protein complexes, is modulated by multifariou...
journal_title：Drug and alcohol dependence
pub_type： 社论
doi：10.1016/j.drugalcdep.2010.03.001
更新日期：2010-05-01 00:00:00
abstract：INTRODUCTION:"Dabbing" involves heating extremely concentrated forms of marijuana to high temperatures and inhaling the resulting vapor. We studied themes describing the consequences of using highly concentrated marijuana by examining the dabbing-related content on Twitter. METHODS:Tweets containing dabbing-related ke...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.06.034
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Many young adults engage in simultaneous alcohol and marijuana (SAM) use so that their effects overlap. Little is known about motivations for dual substance use and associations with use and consequences. This study examined daily-level associations between cross-fading motives and levels of alcohol and mari...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108077
更新日期：2020-05-24 00:00:00
abstract：:Sleep duration and indices of disturbed sleep, such as night-time waking and day-time sleep, were investigated in amphetamine users following hospital admission and withdrawal from the drug. Compared to controls, the amphetamine group showed an initial period of oversleeping and, towards the end of the first week, the...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(82)90010-2
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:An epidemic of opioid overdose has spread across North America, with illicit drug-related overdose emerging as a leading cause of death in recent years. Estimates of opioid use disorder (OUD) prevalence at the level of the public health service delivery area are needed to project resource needs and identify ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108337
更新日期：2020-12-01 00:00:00
abstract：:The literature on opium addiction in Asia reveals widely different sex ratios. Analysis of these reports indicates that community surveys provide the most reliable and valid ratios. Surveys in psychiatric hospitals appear to overreport women, while case registers and surveys in addiction treatment facilities, vends an...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(80)90451-2
更新日期：1980-09-01 00:00:00
abstract：BACKGROUND:This study examined whether starting buprenorphine treatment prior to prison and after release from prison would be associated with better drug treatment outcomes and whether males and females responded differently to the combination of in-prison treatment and post-release service setting. METHODS:Study des...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2016.11.037
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Recanting - denying previous reports of lifetime substance use - occurs frequently in longitudinal investigations of adolescent substance use. While research has focused on how individual differences contribute to recanting, intra-individual factors associated with recanting over time remain understudied. M...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.08.035
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Mental health problems have been identified among soldiers serving in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF), but little is known about the prevalence and management of alcohol misuse in OEF/OIF veterans seen in the Veterans Administration health care system (VA). METHODS:We identified 12,0...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2009.12.025
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:The majority of opioid-dependent individuals in the US in need of drug treatment are not receiving it. It would be useful to understand the characteristics of individuals entering and failing to enter methadone treatment. METHODS:Participants were opioid-dependent adults in Baltimore Maryland recruited from...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.10.016
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Client language is hypothesized to be a mechanism of action in motivational interviewing (MI). Despite the association of change and sustain talk with substance treatment outcomes, it not known whether providers can intentionally influence this language as hypothesized. OBJECTIVE:This is a randomized contro...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2016.11.036
更新日期：2017-03-01 00:00:00
abstract：:The current study explored the judgments individuals with Substance Use Disorders (SUDs) make regarding the authenticity of enjoyment smiles and masking smiles containing traces of negative emotions. Accuracy at identifying the masked negative emotions were also examined. Eye-movements were recorded to observe relatio...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.107842
更新日期：2020-03-01 00:00:00
abstract：:Intranasal cocaine (COC) and oral ethanol (ETOH) were administered to one group of seven research volunteers during daily experimental sessions. Following the determination of baseline subjective and performance measures, an ETOH cocktail (0, 19.4, 38.7 or 58.1 g of ETOH in lemonade) was consumed over a 10-min period....
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(93)80001-u
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:In recent years, scientific evidence has emerged that wastewater-based epidemiology can deliver complementary information concerning the use of different substances of abuse. In this study, the potential of wastewater-based epidemiology in monitoring spatial and temporal trends in alcohol consumption in diff...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.01.002
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:To examine lifetime and current prevalence rates of substance use disorders and the demographic and clinical correlates of current drug dependence in a sample of homeless women. METHODS:A cross-sectional study of 196 homeless women in three Canadian cities was done. Each subject was assessed using structured...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.03.016
更新日期：2011-11-01 00:00:00
abstract：:A total of 72 social drinkers between the ages of 20 and 57 years participated in an ad lib social drinking session. At various intervals throughout the session participants provided estimates of their blood alcohol concentration (BAC) along with breath samples for objective determination of their BAC. Participants we...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(87)90089-5
更新日期：1987-01-01 00:00:00
abstract：:A single dose of ethanol has been shown to affect both striatal and hippocampal high-affinity choline uptake. This effect is probably mediated through effects of ethanol on acetylcholine release. Choline uptake has also been shown to be altered in ethanol-dependent animals, and these effects may be coupled to alterat...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(79)90005-x
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:Monitoring of emerging modes of drug consumption in France has identified new patterns of injection among youths with diverse social backgrounds, which may explain the persistence of high rates of hepatitis C virus infection. The circumstances surrounding the first injection have been poorly documented in th...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.04.026
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Changes in per capita alcohol consumption are temporally linked to changes in rates of alcohol-related harm. Methodological approaches for analysing this relationship have been suggested, however, the problem of time lags is not well-addressed. This study provides a review of time lag specifications, looking...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.drugalcdep.2011.12.005
更新日期：2012-06-01 00:00:00
abstract：:Peripheral and autonomic neuropathy has been evaluated, both by clinical and neurophysiological and by clinical methods, respectively, in 33 alcoholics, 20 of them cirrhotics. Nerve dysfunction was compared with liver function parameters, the Child-Pugh score, and parameters derived from ethanol consumption. Few relat...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(91)90004-i
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVE:The main aim of this study was to examine the risk of exposure to parental substance use disorders (SUD; alcohol or drug abuse or dependence) on the risk for SUD in offspring with and without attention deficit hyperactivity disorder (ADHD) followed into young adult years. METHODS:Subjects were derived from t...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.01.021
更新日期：2018-05-01 00:00:00
abstract：:The aim of this study was to determine if substitution of daily methadone with second daily levo-alpha-acetylmethadol (LAAM) would convert non-holders on methadone into holders on LAAM, and to compare plasma concentration-time profiles of (R)-methadone with LAAM and its two metabolites. Sixteen stable methadone mainte...
journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2004.04.004
更新日期：2004-10-05 00:00:00
abstract：BACKGROUND:To improve measures of monthly tobacco cigarette smoking among non-daily smokers, predictive of future non-daily monthly and daily smoking. METHODS:Data from United States National Longitudinal Study of Adolescent to Adult Health, tracking adolescents, ages 12-21, over 14 years were analyzed. At baseline, 6...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.02.043
更新日期：2016-05-01 00:00:00
abstract：:Alcohol is a known suppressant of the immune system and alcoholics frequently have impaired humoral and cell-mediated immunity. The purpose of this study was to investigate the effect of a single dose of ethanol on the thymus and the possible mechanism of its action. Adult female Wistar rats were divided into three gr...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(92)90024-7
更新日期：1992-06-01 00:00:00
