Abstract:
OBJECTIVE:To examine the characteristics of "diagnostic orphans" among cannabis users - those who report one or two symptoms of DSM-IV dependence but do not meet diagnostic criteria for DSM-IV abuse or dependence - 4 years post-assessment. METHOD:Data were collected from a representative population cohort of young Australian adults. Those who reported that they had used cannabis at least weekly at some point within the past year were assessed for symptoms of DSM-IV cannabis abuse and dependence using the Composite International Diagnostic Interview at age 20-21 years. The entire sample was followed up 4 years later. At age 24-25 years, cannabis use and cannabis diagnostic category were examined according to diagnostic category at age 20-21 years. RESULTS:Diagnostic orphans at age 20-21 years were more likely than non-problem cannabis users at that age to be using cannabis, and to meet criteria for cannabis abuse or dependence 4 years later. Those who had met criteria for cannabis abuse or dependence, however, appeared to be at greater risk relative to non-problematic users and diagnostic orphans of meeting criteria for cannabis abuse and dependence at follow-up. CONCLUSIONS:Young adult diagnostic orphans for cannabis use appear to be at lower risk of meeting full (or partial) diagnostic criteria after a 4-year follow-up, compared to those who had met criteria for cannabis abuse or dependence. This suggests that there is prognostic diagnostic utility in the threshold for dependence symptoms among young adult cannabis users. Diagnostic orphans did appear to be at greater risk than non-problem users for developing dependent and daily cannabis use, however, suggesting that clinicians would do well to intervene with this group.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Degenhardt L,Coffey C,Carlin JB,Swift W,Patton GCdoi
10.1016/j.drugalcdep.2007.07.003subject
Has Abstractpub_date
2008-01-01 00:00:00pages
86-90issue
1-3eissn
0376-8716issn
1879-0046pii
S0376-8716(07)00273-6journal_volume
92pub_type
杂志文章abstract::This double-blind, randomized, placebo-controlled clinical trial evaluated the impact on withdrawal symptoms of (i) combining naltrexone with a 4-day buprenorphine taper for short opioid detoxification (NB Group), compared to (ii) using a 4-day buprenorphine taper alone, followed by naltrexone on day 8 (PB Group). Sub...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0376-8716(99)00033-2
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:HIV transmission risk among non-injection drug users is high due to the co-occurrence of drug use and sexual risk behaviors. The purpose of the current study was to identify patterns of drug use among polysubstance users within a high HIV prevalence population. METHODS:The study sample included 409 substanc...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.03.004
更新日期:2013-10-01 00:00:00
abstract::There have been relatively few studies of genetic factors in drug abuse. Childhood Attention Deficit Hyperactivity Disorder (ADHD) has been implicated as a risk factor, and pedigree studies of Tourette Syndrome (TS), a hereditary impulse disorder closely related to ADHD, show an increased prevalence of substance abuse...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(94)90104-x
更新日期:1994-03-01 00:00:00
abstract:AIM:To evaluate potential mediators of an extended cognitive behavioral smoking cessation intervention. DESIGN:Analysis of data from a randomized clinical trial of smoking cessation. SETTING:The Habit Abatement Clinic, University of California, San Francisco. PARTICIPANTS:Participants were older cigarette smokers (>...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2009.12.021
更新日期:2010-06-01 00:00:00
abstract::A statistical analysis of the MAST scores obtained by its administration to industrial workers, hospitalized alcoholics and persons arrested driving while intoxicated has been performed. The author discusses the modalities and possibilities of improving the test reliability which will increase its efficiency in the sc...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(89)90064-1
更新日期:1989-12-01 00:00:00
abstract::Drug usage patterns among patients admitted to a Swedish clinic specialized in the treatment of drug dependence have undergone significant changes during the last fifteen years. During this period there has been a decline in amphetamine taking and a rise in opiate abuse. Yearly cohorts of drug abusers were subjected t...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(80)90188-x
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVE:Female injection drug users who are also sex workers (FSW-IDUs) occupy a pivotal population in HIV transmission, whereas their mental health problems are largely overlooked. We aimed to investigate prevalence and associated socio-ecological factors of depression, suicidal ideation and suicidal attempts among ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.08.011
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:Medical marijuana use may substitute prescription opioid use, whereas nonmedical marijuana use may be a risk factor of prescription opioid misuse. This study examined the associations between recreational marijuana legalization and prescription opioids received by Medicaid enrollees. METHODS:State-level qua...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.09.016
更新日期:2019-01-01 00:00:00
abstract:AIMS:Carisoprodol is a muscle relaxant that acts at the GABA(A) receptor. Concerns about the abuse liability of carisoprodol are increasing, but evidence that carisoprodol produces tolerance and a significant withdrawal syndrome has yet to be established. The purpose of the current study was to determine if repeated ad...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.10.010
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Web-based personalized normative feedback (PNF) interventions are less effective than their laboratory versions. Participant motivation may account for this reduced effect, but there is only a limited amount of research into the influence of motivation on PNF effectiveness. We evaluated the effectiveness of ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.02.021
更新日期:2019-06-01 00:00:00
abstract:INTRODUCTION:A growing area of research suggests that neuroimmunity may impact the pharmacology of opioids. Microglia is a key component of the brain immunity. Preclinical and clinical studies have demonstrated that microglial modulators may improve morphine-induced analgesia and prevent the development of tolerance an...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.10.037
更新日期:2017-01-01 00:00:00
abstract::In order to determine patterns and correlates of attempted suicide amongst heroin users across 3 years, a cohort of 387 heroin users (134 entering maintenance treatment, 134 entering detoxification, 81 entering residential rehabilitation and 38 not entering treatment) were interviewed about suicide attempts at baselin...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
doi:10.1016/j.drugalcdep.2006.08.010
更新日期:2007-03-16 00:00:00
abstract::The major objectives of the present study were 2-fold: (1) to demonstrate the superiority of receiver operating characteristic (ROC) methodology in the comparison of screening tests that yield continuous values; and (2) to identify the best screening indicator of current drug use disorders in alcoholics. We evaluated ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(88)90056-7
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Previous studies have examined associations between alcohol use in pregnancy and offspring birth size but evidence on whether associations persist during childhood is limited. METHODS:We examined the association between maternal drinking during pregnancy and trajectories of offspring weight and height from ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.02.035
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:The current study examines the prevalence and correlates of lifetime non-fatal overdose (OD) involving the nonmedical use of prescription opioids and tranquilizers among a sample of high-risk young adults in New York, NY and Los Angeles, CA. METHODS:Data were derived from a cross-sectional study of 16-25 ye...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.08.014
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Patients on opioid replacement therapy (ORT) to treat opioid use disorder are frequently monitored for these medications, but it is not known if they are also adhering to their psychotropic medications. This is an analysis of measure of potential adherence to psychotropic medications by patients on ORT. MET...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.08.632
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To identify predictors of perceived (a) risk of harm associated with inhalant use and (b) intention to use inhalants among adolescent inhalant users. METHOD:Participants were 279 lifetime inhalant users (M(age)=15.5, 84% male) identified in a statewide survey of 723 adolescents in Missouri Division of Youth ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2008.04.005
更新日期:2008-09-01 00:00:00
abstract::An initial efficacy test of an innovative behavioral outpatient treatment model for adolescents with problematic use of marijuana enrolled 69 adolescents, aged 14-18, and randomly assigned them to one of two treatment conditions. Both conditions received individualized Motivational Enhancement and Cognitive Behavioral...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2009.07.009
更新日期:2009-12-01 00:00:00
abstract::Propylhexedrine, a sympathomimetic with varied medicinal uses, is one of the compounds to be reviewed by the Expert Committee convened by the World Health Organization (WHO) to determine whether the compound should be scheduled under the Convention on Psychotropic Substances. This paper reviews the pharmacology, medic...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(86)90013-x
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:The DSM specifies categorical criteria for psychiatric disorders. In contrast, a dimensional approach considers variability in symptom severity and can significantly improve statistical power. The current study tested whether a categorical, DSM-defined diagnosis of Alcohol Dependence (AD) was a better fit th...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.12.020
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Ukraine's HIV epidemic, primarily affecting people who inject drugs (PWID), is expanding and transitioning despite free opioid substitution therapy (OST) and antiretroviral therapy (ART), two effective ways to reduce HIV transmission. Police detention of PWID not resulting in a formal charge or imprisonment ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.05.018
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:With the emergence of illicit fentanyl, fentanyl-involved overdose rates increased from 2013 to 2017 in the United States (US). We describe US trends in opioid-related overdose mortality rates by race, age, urbanicity, and opioid type before and after the emergence of fentanyl. METHODS:Using the Centers for...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108321
更新日期:2020-11-01 00:00:00
abstract::Our study compared the results of self-report (SR) plus breath carbon monoxide (CO) monitoring to SR plus urine cotinine (COT) analysis of recent tobacco use for a recently completed smoking cessation study that compared the efficacy of different intensities of psychosocial treatments coupled with 8 weeks of patch tre...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0376-8716(01)00162-4
更新日期:2002-01-01 00:00:00
abstract::The new 'Betäubungsmittelgesetz' (Narcotic drugs law) of the Federal Republic of Germany is analyzed from the viewpoint of punishment vs. treatment. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(85)90010-9
更新日期:1985-08-01 00:00:00
abstract::In the present study the relationship between early-onset ( journal_title:Drug and alcohol dependence pub_type: 杂志文章 doi:10.1016/s0376-8716(99)00132-5 更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Alcohol cues can precipitate the desire to drink and cause relapse in recovering alcohol-dependent patients. Serotonin and dopamine may play a role in alcohol cue-induced craving. Acute combined tryptophan (Trp), tyrosine (Tyr), and phenylalanine (Phe) depletion (CMD) in the diet attenuates the synthesis of ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2012.01.006
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Metabolomics allows the high-throughput analysis of low molecular mass compounds in biofluids, which can reflect the metabolic response of the body to heroin exposure and potentially reveal biomarkers of heroin abuse. METHODS:Heroin was administered to Sprague-Dawley rats in increasing doses from 3 to 16.5 ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.06.031
更新日期:2013-01-01 00:00:00
abstract::We adapted the 32-item Verona Service Satisfaction Scale (VSSS-32) to assess opioid-dependent patient satisfaction with services received from methadone treatment centres. The preliminary version of the VSSS for methadone treatment (VSSS-MT) was filled out anonymously and completed by 516 randomly recruited patients. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(02)00196-5
更新日期:2002-10-01 00:00:00
abstract::The Network for the Improvement of Addiction Treatment (NIATx) teaches participating treatment centers to use process improvement strategies. A cross-site evaluation monitored impacts on days between first contact and first treatment and percent of patients who started treatment and completed two, three and four units...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
doi:10.1016/j.drugalcdep.2006.10.009
更新日期:2007-05-11 00:00:00
abstract::Interest in oral fluid as an alternative matrix for monitoring drug use is due to its ease-of-collection and non-invasiveness; however, limited data are available on the disposition of drugs into oral fluid. The objective of this research was to provide data on the presence and concentrations of heroin, cocaine and mu...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2006.08.020
更新日期:2007-03-16 00:00:00