Abstract:
OBJECTIVE:The main aim of this study was to examine the risk of exposure to parental substance use disorders (SUD; alcohol or drug abuse or dependence) on the risk for SUD in offspring with and without attention deficit hyperactivity disorder (ADHD) followed into young adult years. METHODS:Subjects were derived from two longitudinal case-control studies of probands of both sexes, 6-17 years, with and without DSM-III-R ADHD and their parents. Probands were followed for ten years into young adulthood. Probands with a parental history of non-nicotine SUD were included in this analysis. Exposure to SUD was determined by active non-nicotine parental SUD while the parent was living with their child after birth. Cox proportional hazard models were used to calculate the risk of non-nicotine SUD in offspring. RESULTS:171 of the 404 probands reassessed at ten-year follow up had a family history of parental SUD. 102 probands were exposed to active parental SUD. The average age of our sample was 22.2 ± 3.5 years old. Exposure to maternal but not paternal SUD increased offspring risk for an alcohol use disorder in young adulthood independently of ADHD status (OR: 2.7; 95% CI: 1.1, 6.9; p = 0.04). CONCLUSION:Exposure to maternal SUD increases the risk for an alcohol use disorder in offspring ten years later in young adult years irrespective of ADHD status.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Yule AM,Wilens TE,Martelon M,Rosenthal L,Biederman Jdoi
10.1016/j.drugalcdep.2018.01.021subject
Has Abstractpub_date
2018-05-01 00:00:00pages
154-158eissn
0376-8716issn
1879-0046pii
S0376-8716(18)30126-1journal_volume
186pub_type
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journal_title:Drug and alcohol dependence
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doi:10.1016/j.drugalcdep.2017.10.006
更新日期:2018-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
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更新日期:2017-06-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
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doi:10.1016/j.drugalcdep.2007.10.002
更新日期:2008-03-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
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更新日期:2001-11-01 00:00:00
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更新日期:2014-10-01 00:00:00
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更新日期:2019-11-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.09.013
更新日期:2012-04-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.06.002
更新日期:2007-12-01 00:00:00
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2003-06-05 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2005.05.006
更新日期:2005-12-12 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.12.014
更新日期:2011-07-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.06.002
更新日期:2012-12-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107999
更新日期:2020-07-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(86)90034-7
更新日期:1986-05-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(97)00074-4
更新日期:1997-08-25 00:00:00