Nicotine-induced regulation of tyrosine hydroxylase activity in adrenal gland of transgenic mouse carrying human tyrosine hydroxylase gene.

abstract：:The effect of Ca2+/calmodulin-dependent protein phosphorylation on K+ channels was examined in snail neurons, using several pharmacological agents, the voltage clamp method and the pressure injection technique. H-7, a general protein kinase inhibitor, reduced the delayed outward K+ current (IKD) which was suppressed b...

journal_title：Neuroscience letters

authors： Onozuka M,Furuichi H,Imai S,Fukami Y

更新日期：1991-03-11 00:00:00

abstract：:Recent evidence has suggested that down-regulation of somatostatin (SST) expression in the human brain during early stages of aging leads to an elevation in the steady-state levels of Abeta and therefore may be involved in Alzheimer's disease (AD) progression. We hypothesized that alterations in the SST gene might alt...

journal_title：Neuroscience letters

authors： Xue S,Jia L,Jia J

更新日期：2009-11-13 00:00:00

abstract：:Many studies have shown that minocycline, an antibacterial tetracycline, suppresses experimental pain. While minocycline's positive effects on pain resolution suggest that clinical use of such drugs may prove beneficial, minocycline's antibiotic actions and divalent cation (Ca(2+); Mg(2+)) chelating effects detract fr...

journal_title：Neuroscience letters

authors： Bastos LF,Godin AM,Zhang Y,Jarussophon S,Ferreira BC,Machado RR,Maier SF,Konishi Y,de Freitas RP,Fiebich BL,Watkins LR,Coelho MM,Moraes MF

更新日期：2013-05-24 00:00:00

abstract：:Dinucleotide repeat polymorphism has been observed in the promoter of the alpha-synuclein (alpha-SYN)/NAC precursor protein (NACP) gene. Alpha-SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krüger et al. (Ann. Neurol. 45 (1999) 611) is reported to be signi...

journal_title：Neuroscience letters

authors： Izumi Y,Morino H,Oda M,Maruyama H,Udaka F,Kameyama M,Nakamura S,Kawakami H

更新日期：2001-03-09 00:00:00

abstract：:Assessing the result of conceptual change (i.e., whether an individual has come to correctly understand a science concept) is important in science education, however traditional assessment methods lack objectivity. In this study, permutation entropy (PE) based complexity, a kind of entropy used to quantify the complex...

journal_title：Neuroscience letters

authors： Jin L,Jia H,Li H,Yu D

更新日期：2019-04-23 00:00:00

abstract：:Hearing loss is a common sensory disorder that affects more than 360 million people worldwide, and is primarily caused by the loss of hair cells (HCs). Ototoxic drugs, viral infections, genetic predisposition, aging or noise all damage HCs. 3β-hydroxysteroid-Δ24 reductase (DHCR24), one enzyme in the cholesterol biosyn...

journal_title：Neuroscience letters

authors： Tian KY,Chang HM,Wang J,Qi MH,Wang WL,Qiu Y,Liang K,Chen FQ,Zha DJ,Qiu JH

更新日期：2019-07-27 00:00:00

abstract：:Neurons within the hypothalamic paraventricular nuclei (PVN) have been antidromically invaded following electrical stimulation within the pons and medulla of rats. These neurones are dispersed throughout the PVN and are often found near neurones antidromically invaded only from the pituitary salk. In addition, a small...

journal_title：Neuroscience letters

authors： Zerihun L,Harris M

更新日期：1981-05-06 00:00:00

abstract：:The bed nucleus of the ansa lenticularis (BNAL) was studied by the rapid Golgi method in the mouse. It was composed of large and small neurons; the latter were the main constituents. Dendrites of the BNAL neurons were distributed only within the confines of the ansa lenticularis (AL). Axons of BNAL neurons ran ventrom...

journal_title：Neuroscience letters

authors： Iwahori N,Mizuno N

更新日期：1981-01-20 00:00:00

abstract：:Previous studies have shown significant increases in regional cerebral metabolic rate for glucose (rCMRgl) in 14 of 28 investigated brain structures in rats exposed to 1-h oxygen at 2 atmosphere absolute (ATA O2). Continuous 4-h exposure to 2 ATA O2 resulted in significant increases only in superior olivary nucleus an...

journal_title：Neuroscience letters

authors： Torbati D,Lo P,Lambertsen CJ

更新日期：1984-09-07 00:00:00

abstract：:Previous studies have observed increased tachykinin NK(1) receptor immunoreactivity (NK(1)-IR) in the prefrontal cortex in subjects with schizophrenia. Since the subjects were medicated the possibility of a treatment effect could not be excluded. Thus, the present study was undertaken to determine the effect of chroni...

journal_title：Neuroscience letters

authors： Tooney PA,Anderson WB,Lynch-Frame A,Chahl LA

更新日期：2005-07-22 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Epidemiological studies suggest that the exposure of the herbicide glyphosate may influence the development of PD in humans. In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (...

journal_title：Neuroscience letters

authors： Pu Y,Chang L,Qu Y,Wang S,Tan Y,Wang X,Zhang J,Hashimoto K

更新日期：2020-06-21 00:00:00

abstract：:The study of neural arousal mechanisms has been greatly aided by the discovery of the orexin peptides (orexin A and orexin B), the subsequent identification of the neurons that synthesize these peptides, their projections in the brain, and the distribution of orexin receptors in the central nervous system. Orexin neur...

journal_title：Neuroscience letters

authors： Brown TM,Coogan AN,Cutler DJ,Hughes AT,Piggins HD

更新日期：2008-12-31 00:00:00

abstract：:Malnutrition affects a large number of children worldwide. Inadequate nutrition during pre- and postnatal period may alter brain development resulting in biochemical, physiological and anatomical changes which in turn could cause behavioral abnormalities. The impairment of the central nervous system following protein ...

journal_title：Neuroscience letters

authors： Bonatto F,Polydoro M,Andrades ME,Conte da Frota ML Jr,Dal-Pizzol F,Rotta LN,Souza DO,Perry ML,Fonseca Moreira JC

更新日期：2006-10-09 00:00:00

abstract：:In the present study, newborn male Wistar rats were injected, subcutaneously, five times, every other day, with monosodium glutamate (MSG, 4 g/kg bw) or saline (as control, C), during the neonatal period. MSG animals developed destruction of the arcuate nuclei (ARC) with absence of NPY-immunoreactive cell bodies, whic...

journal_title：Neuroscience letters

authors： de Andrade IS,Gonzalez JC,Hirata AE,Carneiro G,Amado D,Cavalheiro EA,Dolnikoff MS

更新日期：2006-05-01 00:00:00

abstract：:Nogo-A is an inhibitor of neurite outgrowth and axonal regeneration after CNS injury. Several functional regions including Nogo-66 were identified to mediate the inhibitory effect of Nogo-A. We have reported that Nogo-66 could promote neural progenitors to differentiate into glial cells. Here we exam three other regio...

journal_title：Neuroscience letters

authors： Gao Y,Xiao Z,Chen B,Wang B,Han J,Zhao Y,Zhang J,Dai J

更新日期：2009-07-24 00:00:00

abstract：:The aim of this study was to examine the expression profiles of N-methyl-D-aspartate (NMDA) receptor subunits in rats during seizure development and kindled process induced by pentylenetetrazole (PTZ). Using quantitative Western blotting, the levels of NR1, NR2A and NR2B subunits were measured in the cortex and hippoc...

journal_title：Neuroscience letters

authors： Zhu LJ,Chen Z,Zhang LS,Xu SJ,Xu AJ,Luo JH

更新日期：2004-02-06 00:00:00

abstract：:Recent imaging studies have reported the projection of semicircular canal signals onto wide regions of the cerebral cortex but little is known about otolith projections onto the cerebral cortex. We used functional magnetic resonance imaging (fMRI) to investigate the activation of the cortex by loud clicks that selecti...

journal_title：Neuroscience letters

authors： Miyamoto T,Fukushima K,Takada T,de Waele C,Vidal PP

更新日期：2007-08-09 00:00:00

abstract：:A late hyperpolarization (LH) which follows low level to moderate synaptic stimulation of neurons in the hippocampal formation neurons was previously shown to consist primarily of a potassium conductance. The present experiments showed that when extracellular cesium was present in order to reduce anamolous rectificati...

journal_title：Neuroscience letters

authors： Thalmann RH

更新日期：1984-04-20 00:00:00

abstract：:A new dipole tracing method, based on a realistic head model, was used to determine dipole locations and vector moments of interictal convexity sharp waves recorded (with conventional EEG technique) from the right fronto-temporal region in a patient with partial complex seizures. When the dipole locations in the head ...

journal_title：Neuroscience letters

authors： Homma S,Nakajima Y,Musha T,Okamoto Y,Hagbarth KE,Blom S,Flink R

更新日期：1990-05-31 00:00:00

abstract：:Epileptic seizures are frequent in patients with glioma, and anticonvulsive treatment is often indicated. Glioma cells release glutamate via the Xc- antiporter system, which appears to be a major pathomechanism of glioma-associated seizures and excitotoxicity. In addition, the proliferation and survival of the tumor c...

journal_title：Neuroscience letters

authors： Mayer J,Kirschstein T,Resch T,Porath K,Krause BJ,Köhling R,Lange F

更新日期：2020-01-10 00:00:00

abstract：:The dopamine transporter (DAT1) gene has been implicated in the pathogenesis of many neuropsychiatric disorders, including schizophrenia. The present study aimed to investigate association of the DAT1 gene polymorphisms with schizophrenia in a Han Chinese population. Two single nucleotide polymorphisms (SNPs) in the D...

journal_title：Neuroscience letters

authors： Zheng C,Shen Y,Xu Q

更新日期：2012-04-04 00:00:00

abstract：:Cultures were produced from retinas taken from human foetuses. Specific cells in culture have the capacity to take up exogenous serotonin, which was then visualized by immunofluorescence using an antisera to serotonin. The known serotonergic uptake blocker, chlorimipramine, inhibited the uptake of the amine while benz...

journal_title：Neuroscience letters

authors： Osborne NN,Beaton DW

更新日期：1985-04-09 00:00:00

abstract：:Our previous work has established that adenosine is toxic to chick embryonic sympathetic neurons and kills freshly plated neurons by a process of apoptosis. Although the exact mechanism remains unknown, we found that phosphorylation of adenosine was essential to the toxicity. Using markers for RNA ([3H]uridine) and pr...

journal_title：Neuroscience letters

authors： Kulkarni JS,Przywara DA,Wakade TD,Wakade AR

更新日期：1998-06-05 00:00:00

abstract：:Interleukin-1 (IL-1) mediates numerous responses on the mouse anterior pituitary cell line AtT-20. We have studied the ligand binding properties of the IL-1 receptors (IL-1R) of the AtT-20 cells and found that they possess 1.5 x 10(3) receptors/cell with a Kd of 0.15 nM for [125I]IL-1 alpha. Using oligonucleotide prim...

journal_title：Neuroscience letters

authors： Bristulf J,Simoncsits A,Bartfai T

更新日期：1991-07-22 00:00:00

abstract：:Dopamine receptor D4 (DRD4) is activated by the neurotransmitter dopamine and links to many neurological and psychiatric conditions because of its close relationship with prefrontal cortex and other important brain regions. To explore the possibility that genetic variants of DRD4 gene predispose to children with menta...

journal_title：Neuroscience letters

authors： Zhang K,Zhang M,He H,Zhang J,Chi W,Guo Y,Huang S,Zheng Z,Zhang F,Gao X

更新日期：2012-05-10 00:00:00

abstract：:Although corticotropin-releasing factor (CRF) is thought to act as a neurotransmitter to activate the locus coeruleus (LC) during hypotensive stress, the consequences of LC activation by CRF are unknown. In the present study a hypotensive challenge that activated rat LC neurons also produced cortical electroencephalog...

journal_title：Neuroscience letters

authors： Page ME,Berridge CW,Foote SL,Valentino RJ

更新日期：1993-12-24 00:00:00

abstract：:Stress increases associative learning and the density of dendritic spines in the hippocampus of male rats. In contrast, exposure to the same stressor impairs associative learning and reduces spine density in females. These effects in females are most evident when they are in the proestrus phase of the estrous cycle. A...

journal_title：Neuroscience letters

authors： Dalla C,Whetstone AS,Hodes GE,Shors TJ

更新日期：2009-01-02 00:00:00

abstract：:The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, ...

journal_title：Neuroscience letters

authors： Bergamaschi S,Binetti G,Govoni S,Wetsel WC,Battaini F,Trabucchi M,Bianchetti A,Racchi M

更新日期：1995-12-01 00:00:00

abstract：:The pattern and distribution of the cortical projections from intermediate parts of the cholinergic basal magnocellular nucleus were studied by anterogradely transported Phaseolus vulgaris-leucoagglutinin. This immunocytochemical tracing technique reveals the detailed morphology and distribution of efferents from this...

journal_title：Neuroscience letters

authors： Luiten PG,Spencer DG Jr,Traber J,Gaykema RP

更新日期：1985-06-12 00:00:00

abstract：:The longest central nervous system (CNS) specific isoform of the major myelin-associated inhibitor of neurite growth, Nogo-A, has previously been shown to be expressed largely in oligodendrocytes. Using an antibody raised against a recombinant fusion protein comprising amino acids 223-399 of Nogo-A, we show in this re...

journal_title：Neuroscience letters

authors： Liu H,Ng CE,Tang BL

更新日期：2002-08-16 00:00:00