Abstract：
:Scarring, leading to impaired function, growth and appearance, is a major problem following many forms of surgery. Fetal wounds, unlike those in the adult, are characterised by a reduced growth factor profile and the absence of scar tissue (Whitby & Ferguson, 1991 a, b). The antiparasitic drug, suramin (a heparin analogue) inhibits binding of various growth factors (e.g. PDGF, bFGF, TGF-beta, EGF, IGF-I, IGF-II) to their receptors in vitro. These growth factors play key roles in wound healing. We attempted to manipulate experimentally their effectiveness in healing adult rat dermal incisional wounds by injecting suramin into the wound margins and comparing the resultant healing with an unmanipulated control wound in the same animal. Immunohistochemical staining demonstrated that, on d 7 and 14 postwounding, the numbers of monocytes/macrophages and blood vessels are markedly increased in suramin treated wounds compared with controls. Extracellular matrix deposition is lower, although very compact in organisation, lacking the usual honeycombed appearance of normal skin. These effects are widespread, being present not only in the wound area, but also in the surrounding tissue. No difference was detected at 70 d postwounding between the scars of suramin-treated and unmanipulated control wounds in the same animals. All such effects are increased slightly through the concentration range of 0.04-40 mg/kg suramin, with no significant change as concentrations greater than 40 mg/kg are applied. This suggests that suramin has marked effects on the early stages of wound healing, which plateau at 40 mg/kg concentration, but has no effect on scar formation.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Chamberlain J,Shah M,Ferguson MWsubject
Has Abstractpub_date
1995-02-01 00:00:00pages
87-96eissn
0021-8782issn
1469-7580journal_volume
186 ( Pt 1)pub_type
杂志文章abstract：:A quantitative analysis of the motor innervation of intrafusal muscle fibres is described, based on teased silver-impregnated spindles of the tenuissimus muscle of the cat. Included in the analysis are the number and distribution of intrafusal branches of both skeletofusimotor (beta) and purely fusimotor (gamma) axons...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Rodents are defined by a uniquely specialized dentition and a highly complex arrangement of jaw-closing muscles. Finite element analysis (FEA) is an ideal technique to investigate the biomechanical implications of these specializations, but it is essential to understand fully the degree of influence of the different i...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01436.x
更新日期：2011-12-01 00:00:00
abstract：:By relating an animal's morphology to its functional role and the behaviours performed, we can further develop our understanding of the selective factors and constraints acting on the adaptations of great apes. Comparison of muscle architecture between different ape species, however, is difficult because only small sa...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01383.x
更新日期：2011-08-01 00:00:00
abstract：:Cellullar deficits are replenished within the central nervous system (CNS) by progenitors to maintain integrity and recover function after injury. NG2 proteoglycan-expressing progenitors replenish oligodendrocyte populations, but the nature of NG2 proteoglycan may not indicate a restricted population of progenitors. A...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2005.00480.x
更新日期：2005-12-01 00:00:00
abstract：:The axial musculoskeletal system of quadrupedal mammals is not currently well understood despite its functional importance in terms of facilitating postural stability and locomotion. Here we examined the detailed architecture of the muscles of the vertebral column of two breeds of dog, the Staffordshire bull terrier (...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12208
更新日期：2014-09-01 00:00:00
abstract：:Mobilisation of the latissimus dorsi muscle as a functional graft necessarily involves division of perforating arteries that enter the distal portion of the muscle, rendering it vulnerable to ischaemic damage when the muscle is stimulated electrically. Using a fluorescent microsphere technique we showed that the blood...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1998.19310093.x
更新日期：1998-07-01 00:00:00
abstract：:The articular facets of the sustentaculum tali have a variety of configurations that are generally viewed as nonmetric traits of little functional significance. Bruckner (1987), in contrast, has hypothesised that sustentaculum tali facet variations are functionally important because they influence subtalar joint stabi...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Angiogenesis is essential for the replacement of cartilage by bone during growth and repair. In order to obtain a better understanding of the mechanisms regulating vascular invasion at sites of endochondral ossification we have investigated the expression of the endothelial cell-specific mitogen, vascular endothelial ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1999.19440519.x
更新日期：1999-05-01 00:00:00
abstract：:This review describes the progress made in preparing Cochrane systematic reviews of randomized controlled trials for Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and the demyelinating neuropathies associated with paraproteins. The di...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.2002.00041.x
更新日期：2002-04-01 00:00:00
abstract：:Primates have shoulders adapted to a wide range of locomotor functions from terrestrial pronograde quadrupedalism to highly arboreal suspensory behaviours. The shape of the scapula tightly follows these functional differences. Previous analyses of primate postcrania, including the scapula, indicate that quadrupedal mo...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00639.x
更新日期：2006-11-01 00:00:00
abstract：:A study has been made, using light and electron microscopy, of GMG cells in the labyrinthine placenta of the mouse. GMG cells were found lying within the lumina of the maternal blood spaces showed degenerative changes and GMG cells were usually found close to these degenerate trophoblast cells. Sometimes the GMG cells...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:Differences are reported in the total calcified tissue/bone marrow ratios and in the total thickness of cortical calcified tissue (lamellar bone and calcified fibrocartilage) between the attachment sites of the quadriceps tendon and the patellar ligament in man. The greatest amount of calcified tissue is at the insert...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:Chromaffin cells were observed singly or in clusters in the heart and sympathetic cord of 2 genera of dipnoan fish, Protopterus and Lepidosiren. They were invariably found in close association with the autonomic sympathetic nervous system and at sites where chromaffin cells or their precursors are situated in mammals ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:This study examined NADPH-d and nNOS expression in the SCG of hamsters. By light microscopy, numerous NADPH-d/NOS positive processes were widely distributed in the ganglion. Ultrastructurally, the NADPH-d reaction product was associated with the membranous organelles of neuronal soma, dendrites, myelinated fibres, sma...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19730461.x
更新日期：2000-10-01 00:00:00
abstract：:This study presents, for the first time, sequences of five beta-keratin cDNAs from turtle epidermis obtained by means of 5'- and 3'-rapid amplification of cDNA ends (RACE) analyses. The deduced amino acid sequences correspond to distinct glycine-proline-serine-tyrosine rich proteins containing 122-174 amino acids. In ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01030.x
更新日期：2009-02-01 00:00:00
abstract：:The present study has shown that the secondary curvature in the cervical spine of the human fetus develops at a much earlier age than has been thought. It may, in fact, develop soon after the embryo first acquires a neck and begins to uncurl. The early appearance of this curvature may be related to the early developme...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
abstract：:In the intestine, changes of sugar concentration generated in the lumen during digestion induce adaptive responses of glucose transporters in the epithelium. A close matching between the intestinal expression of glucose transporters and the composition and amount of the diet has been provided by several experiments. F...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01385.x
更新日期：2011-08-01 00:00:00
abstract：:Since their discovery in different human tissues by Zimmermann in 1898, primary cilia have been found in the vast majority of cell types in vertebrates. Primary cilia are considered to be cellular antennae that occupy an ideal cellular location for the interpretation of information both from the environment and from o...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12360
更新日期：2015-10-01 00:00:00
abstract：:Apart from molecular data, nearly all the evidence used to study primate relationships comes from hard tissues. Here, we provide details of the first parsimony and Bayesian cladistic analyses of the order Primates based exclusively on muscle data. The most parsimonious tree obtained from the cladistic analysis of 166 ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01403.x
更新日期：2011-09-01 00:00:00
abstract：:Although seen frequently during dissections and autopsies, Hyperostosis frontalis interna (HFI) - a morphological pattern of the frontal bone thickening - is often ignored and its nature and development are not yet understood sufficiently. Current macroscopic classification defines four grades/stages of HFI based on t...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12506
更新日期：2016-11-01 00:00:00
abstract：:The seminal vesicles are the glands of male reproductive organs that produce the fluid and nutrient constituents of semen. It has been believed for a long time that the lumen of a seminal vesicle was a single-coiled tubular structure with irregular diverticula. There are several previous reports on the symmetry, diffe...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13269
更新日期：2020-12-01 00:00:00
abstract：:Proximal femoral morphology and associated musculature are of special relevance to the understanding of hominoid locomotor systems. Knowledge of bone-muscle correspondence in extant hominoids forms an important comparative basis for inferring structure-function relationships in fossil hominids. However, there is still...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12270
更新日期：2015-03-01 00:00:00
abstract：:The proximal stump of the optic nerve was examined by electron microscopy from 1 d to 8 wk (dpo/wpo) after intraorbital transection. At 1 dpo a layer of axonal, cytoplasmic and myelin debris approximately 15 microns thick was present at the cut end. A zone approximately 25 microns thick of abnormal and partly degenera...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:It is currently thought that New World monkeys, prosimians, and humans are the only primates to possess vomeronasal organs (VNOs) as adults. Recent studies of the human VNO suggest that previous investigations on Old World primates may have missed the VNO. We examined nasal septa from the chimpanzee (Pan troglodytes) ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19810077.x
更新日期：2001-01-01 00:00:00
abstract：:The ultrastructure of 3 fibrocartilages is described at the insertion of the adult rat Achilles tendon. Enthesial fibrocartilage lies at the tendon-bone junction, sesamoid fibrocartilage in the deep surface of the tendon where it presses on the calcaneus, and periosteal fibrocartilage covers the opposing surface of th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:Connective tissue function is defined as the formation and maintenance of shape, without which centralised physiologies (circulatory, digestive or nervous) could not have evolved. Two elements, inextensible (collagenous) fibrils and compression-resistant interfibrillar soluble polymers (proteoglycans), cope with all u...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：:The normal number and arrangement of motoneurons contributing fibres, via the median and radial nerves, to the forearm muscles of the rat were determined at different stages of postnatal development. Horseradish peroxidase was applied directly to the proximal cut ends of the nerves in 5, 10, 21 days old and adult rats...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:The collagen in the endoneurium is present as argyrophilic reticular fibres, which show up as thin, weakly birefringent greenish fibres when studied by aid of the Picrosirius-polarization method, and are composed of loosely arranged thin collagen fibrils. The epineurium consists of thick non-argyrophilic collagen fibr...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
abstract：:Knowledge of variations in the morphology of normal myelinated peripheral nerve fibres is fundamental to subsequent interpretation of neuropathology. It would be advantageous for structural analysis of normal variations to be based on entire myelin internodes, but acquisition of such data via the classic approach of n...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:The aim of the study was to examine by means of stereology the effects of pinealectomy and melatonin on the structure of the adrenal cortex of ovariectomised rats and to check whether the effect of oestradiol on the rat adrenal cortex is modified by the pineal gland. Neither pinealectomy (73 days) nor melatonin treatm...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
