Cushing's disease due to female gonadotroph adenoma of the pituitary.

abstract：:A young man is reported with an autoimmune polyglandular syndrome (APS) characterized by Addison's disease, primary hypothyroidism, primary hypogonadism, vitiligo, associated with primary empty sella and partial impairment of pituitary hormone secretion. Two years later the patient showed a null cell type acute lympho...

journal_title：Clinical endocrinology

authors： De Rosa G,Della Casa S,Corsello SM,Cecchini L,Callà C

更新日期：1987-11-01 00:00:00

abstract：:The cardiovascular response and the changes of plasma arginine vasopressin (AVP) concentration following graded doses of AVP infused intravenously have been defined in six normal young men. The same measurements were also made during fluid deprivation in a patient with both nephrogenic diabetes insipidus and systemic ...

journal_title：Clinical endocrinology

authors： Khokhar AM,Slater JD,Ma J,Ramage CM

更新日期：1980-09-01 00:00:00

abstract：OBJECTIVE:Polymorphisms in the thyroid transcription factor forkhead factor E1 (FOXE1) gene have been implicated in the genetic susceptibility to differentiated thyroid cancer, but little is known about their effect on tumour characteristics. The objective of this study was to determine the contribution of the FOXE1 po...

journal_title：Clinical endocrinology

authors： Raimundo J,Alvelos MI,Azevedo T,Martins T,Rodrigues FJ,Lemos MC

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the volumetric bone mineral density (BMD) in girls with Turner's syndrome (TS) before and during growth hormone (GH) treatment in combination with low dose oestrogens as well as three years after discontinuation of GH treatment. DESIGN:In a prospective, randomized injectio...

journal_title：Clinical endocrinology

authors： Sass TC,De Muinck Keizer-Schrama SM,Stijnen T,Asarfi A,Van Leeuwen WJ,Van Teunenbroek A,Van Rijn RR,Drop SL

更新日期：2000-05-01 00:00:00

abstract：:Using a sensitive enzyme amplified immunoassay for TSH, the evening rise and pulsatile release of TSH were studied in 10 men with chronic renal failure treated by haemodialysis. Compared to euthyroid male controls the evening rise of TSH was attenuated (median 0.066 vs 0.195 mU/l/h, P less than 0.01) and the rate of r...

journal_title：Clinical endocrinology

authors： Wheatley T,Clark PM,Clark JD,Holder R,Raggatt PR,Evans DB

更新日期：1989-07-01 00:00:00

abstract：:Recent reports have shown that thyroid-stimulating immunoglobulins (TSI) may be detected by measuring cyclic AMP increases in cultures of isolated thyroid cells in response to added patient immunoglobulins (Ig). We have compared the frequency that TSI may be detected in the Ig fraction of 114 sera from 112 patients wi...

journal_title：Clinical endocrinology

authors： Grant SJ,Luttrell BM,Hales IB

更新日期：1985-10-01 00:00:00

abstract：:Eleven women with secondary amenorrhoea and hyperprolactinaemia were treated with lisuride, a new semisynthetic ergot derivative. Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects. In these nine patients, prolonged treatment wit...

journal_title：Clinical endocrinology

authors： De Cecco L,Foglia G,Ragni N,Rossato P,Venturini PL

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Acylation-stimulating protein (ASP) is an adipose tissue-derived hormone, which stimulates glucose and free fatty acid (FFA) uptake into adipocytes. Changes in ASP metabolism are associated with alterations in lipid metabolism. As postnatal catch-up growth has been associated with dyslipidaemia in...

journal_title：Clinical endocrinology

authors： Leunissen RW,Gao Y,Cianflone K,Stijnen T,Hokken-Koelega AC

更新日期：2010-06-01 00:00:00

abstract：:Prospective observational studies uniformly link vitamin D deficiency with the incidence of type 2 diabetes mellitus (T2DM), yet trials supplementing participants at risk of T2DM with vitamin D to reduce progression to T2DM have yielded inconsistent results. Inconsistencies between supplementation trials may be due to...

journal_title：Clinical endocrinology

authors： Shore-Lorenti C,Brennan SL,Sanders KM,Neale RE,Lucas RM,Ebeling PR

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:We aim to evaluate the association of PCOS with eating, sleeping and sexual function disorders. METHODS:A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through 01 August 2018 was conducted for studies reportin...

journal_title：Clinical endocrinology

authors： Thannickal A,Brutocao C,Alsawas M,Morrow A,Zaiem F,Murad MH,Javed Chattha A

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Peripheral aromatization of testosterone and androstenedione is the principal source for circulating oestrogens in men and in castrated and post-menopausal women. Since human bone is a target organ for androgens and oestrogens, aromatase activity was assessed in human spongiosa obtained from pa...

journal_title：Clinical endocrinology

authors： Schweikert HU,Wolf L,Romalo G

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:Previous studies have suggested that hypothyroidism affects both systolic and diastolic cardiac function. We have applied equilibrium radionuclide angiography to the study of heart function at rest in hypothyroidism. DESIGN:A prospective study, evaluating cardiac function at rest in primary hypothyroidism. ...

journal_title：Clinical endocrinology

authors： Tielens ET,Pillay M,Storm C,Berghout A

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:To assess possible side-effects of long-term continuous growth hormone (GH) treatment on carbohydrate (CH) metabolism in children with short stature born small for gestational age. DESIGN:In a prospective, randomised double-blind, dose-response multicentre trial, the effect of GH treatment on CH metabolism w...

journal_title：Clinical endocrinology

authors： Sas T,Mulder P,Aanstoot HJ,Houdijk M,Jansen M,Reeser M,Hokken-Koelega A

更新日期：2001-02-01 00:00:00

abstract：CONTEXT:The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective...

journal_title：Clinical endocrinology

authors： Celi FS,Zemskova M,Linderman JD,Babar NI,Skarulis MC,Csako G,Wesley R,Costello R,Penzak SR,Pucino F

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Infusion of GH secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted GH secretion associated with a substantial IGF-I rise. Here we report the dynamic characteristics of spontaneous nightly TSH and PRL secre...

journal_title：Clinical endocrinology

authors： Van den Berghe G,de Zegher F,Veldhuis JD,Wouters P,Gouwy S,Stockman W,Weekers F,Schetz M,Lauwers P,Bouillon R,Bowers CY

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:While an association between androgens and the metabolic syndrome (MS) is well established in obese women, studies concerning this relationship are scarce in obese adolescent girls. Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group. METHODS:In ...

journal_title：Clinical endocrinology

authors： de Sousa G,Brodoswki C,Kleber M,Wunsch R,Reinehr T

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:The impact of exogenous GH on thyroid function remains controversial although most data add support to a stimulation of peripheral T4 to T3 conversion. For further elucidation we evaluated iodothyronine and circadian TSH levels in GH-deficient patients as part of a GH dose-response study. PATIENTS:Eight GH-d...

journal_title：Clinical endocrinology

authors： Jørgensen JO,Møller J,Laursen T,Orskov H,Christiansen JS,Weeke J

更新日期：1994-11-01 00:00:00

abstract：:In order to investigate the endocrine requirements for induction of follicle maturation, ovulation and luteal function we have measured plasma LH and FSH concentrations in 109 cycles induced by treatment with LHRH in 25 women with amenorrhoea of diverse aetiology. The major clinical and endocrine subgroupings were pol...

journal_title：Clinical endocrinology

authors： Abdulwahid NA,Adams J,van der Spuy ZM,Jacobs HS

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The immediate early gene locus AP-1, incorporating the cellular oncogenes c-fos and c-jun (and their oncoprotein products Fos and Jun respectively) play a key role in regulating cell growth and differentiation. The myc-gene is also known to promote cell growth. In order to investigate the possible ...

journal_title：Clinical endocrinology

authors： Raghavan R,Harrison D,Ince PG,James RA,Daniels M,Birch P,Caldwell GI,Kendall-Taylor P

更新日期：1994-01-01 00:00:00

abstract：:The excretion of FSH, LH, oestrogens and pregnanediol was monitored once weekly in urine samples collected from eight peri-menopausal women aged 44-55 years (median, 52 years). Observations were commenced between 5 and 15 weeks before the menopause and were continued for 22-30 weeks after final menstruation. Amenorrho...

journal_title：Clinical endocrinology

authors： Metcalf MG,Donald RA,Livesey JH

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:The prevalence of clinically silent corticotroph macroadenomas is unknown. Our aim was to determine the prevalence of clinically silent corticotroph macroadenomas among all pituitary macroadenomas. DESIGN:Patients scheduled to have transsphenoidal surgery for any sellar mass were prospectively evaluated clin...

journal_title：Clinical endocrinology

authors： Guttenberg KB,Mayson SE,Sawan C,Kharlip J,Lee JY,Martinez-Lage M,Loevner LA,Ewanichak J,Grady MS,Snyder PJ

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:The purpose was to investigate whether the function of the pinealocytes is changed in patients with disturbed metabolic rate or in subjects with marked obesity. DESIGN:Venous blood was sampled every second hour between 1800 and 0800 h, and urine collected between 2200 and 0700 h. PATIENTS:Eight patients wit...

journal_title：Clinical endocrinology

authors： Röjdmark S,Berg A,Rössner S,Wetterberg L

更新日期：1991-07-01 00:00:00

abstract：:3-M syndrome is an autosomal recessive primordial growth disorder characterized by small birth size and post-natal growth restriction associated with a spectrum of minor anomalies (including a triangular-shaped face, flat cheeks, full lips, short chest and prominent fleshy heels). Unlike many other primordial short st...

journal_title：Clinical endocrinology

authors： Clayton PE,Hanson D,Magee L,Murray PG,Saunders E,Abu-Amero SN,Moore GE,Black GC

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To assess current provision of specialist and transitional paediatric endocrine services in the UK and Ireland. DESIGN:A questionnaire was sent to paediatric endocrinologists requesting details of patients receiving GH and also details of specialist and transitional services. RESULTS:Of 72 questionnaires re...

journal_title：Clinical endocrinology

authors： Kirk J,Clayton P

更新日期：2006-07-01 00:00:00

abstract：CONTEXT:Animal data and cross-sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute hyponatraemia on bone turnover have not been determined. Our objective was to test the hypothesis that acute hyponatraemia leads to dynamic effects on bone turnover. DESIG...

journal_title：Clinical endocrinology

authors： Garrahy A,Galloway I,Hannon AM,Dineen R,Javadpour M,Tormey WP,Gan KJ,Twomey PJ,Mc Kenna MJ,Kilbane M,Crowley RK,Sherlock M,Thompson CJ

更新日期：2020-11-11 00:00:00

abstract：:The age-dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in the elderly by their effects on muscle mass and bone mineral density. However, for healthy men data on serum oestrogens and androgens, as well as IGF-1, as a common outcome measure covering the whole adult age range ar...

journal_title：Clinical endocrinology

authors： Leifke E,Gorenoi V,Wichers C,Von Zur Mühlen A,Von Büren E,Brabant G

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVES:Patients with type 1 diabetes are at increased risk of cardiovascular disease, which may be related to abnormal lipid metabolism. Secretion and clearance of VLDL apolipoprotein B100 (apoB) are important determinants of plasma lipid concentrations and are known to be influenced by hormones, including insulin ...

journal_title：Clinical endocrinology

authors： Christ ER,Carroll PV,Albany E,Umpleby AM,Lumb PJ,Wierzbicki AS,Simpson HL,Sönksen PH,Russell-Ones DL

更新日期：2001-12-01 00:00:00

abstract：:To quantify the role of endogenous oestrogen activity in osteoporosis we measured relative metacarpal cortical area (RCA), body mass, serum oestrone, oestradiol, androstenedione, and sex hormone binding globulin (SHBG) in 746 postmenopausal women aged 53 to 76 years, sampled from the general population. The occurrence...

journal_title：Clinical endocrinology

authors： van Hemert AM,Birkenhäger JC,De Jong FH,Vandenbroucke JP,Valkenburg HA

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVE:Pseudohypoparathyroidism type Ia (PHP-Ia) is a hereditary disorder characterized by resistance to multiple hormones that work via cAMP such as PTH and TSH, accompanied by typical skeletal features including short stature and brachydactyly, termed Albright hereditary osteodystrophy (AHO). In affected kindreds,...

journal_title：Clinical endocrinology

authors： Mouallem M,Shaharabany M,Weintrob N,Shalitin S,Nagelberg N,Shapira H,Zadik Z,Farfel Z

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:The present study was performed to characterize the molecular heterogeneity of serum FSH in normal males and to investigate the possible influence of testosterone on serum FSH in androgen-deficient men before and during testosterone administration. DESIGN AND PATIENTS:Serum samples were taken at 10-minute in...

journal_title：Clinical endocrinology

authors： Harsch IA,Simoni M,Nieschlag E

更新日期：1993-08-01 00:00:00