Abstract:
BACKGROUND/OBJECTIVES:Acylation-stimulating protein (ASP) is an adipose tissue-derived hormone, which stimulates glucose and free fatty acid (FFA) uptake into adipocytes. Changes in ASP metabolism are associated with alterations in lipid metabolism. As postnatal catch-up growth has been associated with dyslipidaemia in later life, we investigated the association between ASP and birth size, adult size and different growth patterns during childhood. METHODS:The associations were investigated by multiple regression analyses in 285 young adults, aged 18-24. Subsequently, differences in ASP were analysed in four clinically relevant subgroups, young adults either born small for gestational age with short stature (SGA-S) or with catch-up growth (SGA-CU), or born appropriate for gestational age with idiopathic short stature (ISS) or with normal stature (controls). RESULTS:Weight gain during childhood, particularly fat accumulation, was positively related to ASP levels in early adulthood, independent of birth size, age and gender. Foetal growth, reflected by birth size, was not related to ASP levels. Between the subgroups, no differences in ASP were found, but SGA-CU and ISS subjects had significantly higher levels of FFA. CONCLUSION:Exaggerated weight gain during childhood, but not foetal growth, contributes to alterations in ASP metabolism, which may be associated with impaired FFA uptake and delayed triglycerides clearance. Therefore, exaggerated weight gain during childhood should be prevented.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Leunissen RW,Gao Y,Cianflone K,Stijnen T,Hokken-Koelega ACdoi
10.1111/j.1365-2265.2010.03771.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
775-80issue
6eissn
0300-0664issn
1365-2265pii
CEN3771journal_volume
72pub_type
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1992.tb02907.x
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journal_title:Clinical endocrinology
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doi:10.1111/cen.12613
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1994.tb01816.x
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journal_title:Clinical endocrinology
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doi:10.1111/cen.14293
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doi:10.1111/j.1365-2265.2005.02344.x
更新日期:2005-09-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1978.tb01506.x
更新日期:1978-12-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.2008.03195.x
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1982.tb03150.x
更新日期:1982-01-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1995.tb02037.x
更新日期:1995-09-01 00:00:00
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doi:10.1046/j.1365-2265.1998.00460.x
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1992.tb02902.x
更新日期:1992-01-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1985.tb02997.x
更新日期:1985-05-01 00:00:00
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更新日期:1995-04-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2018-05-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1983.tb03211.x
更新日期:1983-03-01 00:00:00
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更新日期:2017-06-01 00:00:00
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doi:10.1111/j.1365-2265.1983.tb00008.x
更新日期:1983-09-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.2010.03879.x
更新日期:2011-01-01 00:00:00
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journal_title:Clinical endocrinology
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更新日期:2015-04-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.2004.02102.x
更新日期:2004-09-01 00:00:00