Body fat predicts an increase and limb muscle strength predicts a decrease in leptin in older adults over 2·6 years.

abstract：:Vasoactive intestinal peptide (VIP) is a highly basic 28 amino-acid peptide which was first isolated from porcine small intestine (Said & Mutt, 1970). It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences si...

journal_title：Clinical endocrinology

authors： Prysor-Jones RA,Jenkins JS

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:Serum testosterone concentrations are affected by factors unrelated to hypothalamo-pituitary-testicular axis pathology. We evaluated the impact of sociodemographic, lifestyle and medical factors, on serum testosterone and sex hormone-binding globulin (SHBG) in men aged 40-69 years. DESIGN:Cross-sectional ana...

journal_title：Clinical endocrinology

authors： Yeap BB,Marriott RJ,Antonio L,Bhasin S,Dobs AS,Dwivedi G,Flicker L,Matsumoto AM,Ohlsson C,Orwoll ES,Raj S,Reid CM,Vanderschueren D,Wittert GA,Wu FCW,Murray K

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:The recent American Thyroid Association management guidelines suggest cervical ultrasonography (US) surveillance in patients with differentiated thyroid cancer (DTC). This study was conducted to identify predictive factors that can determine whether subsequent fine needle aspiration guided by ultrasound (US-...

journal_title：Clinical endocrinology

authors： Hahn SY,Shin JH,Han BK,Ko EY,Kang SS,Chung JH,Kim JH,Oh YL,Son YI

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

journal_title：Clinical endocrinology

authors： Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To compare the value of the thyroid imaging reporting and data system proposed by Kwak (KWAK TI-RADS) and the 2015 American Thyroid Association (ATA) guidelines for diagnosis of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). To confirm the role of cell block (CB)-assisted fine-needle...

journal_title：Clinical endocrinology

authors： Li J,Li H,Yang Y,Zhang X,Qian L

更新日期：2020-05-01 00:00:00

abstract：:A wide variety of adverse effects of methimazole (MMI) have been reported. Here we report a new MMI-induced disorder, acute pancreatitis and parotitis. Three weeks after a woman started MMI treatment for Graves' disease, she developed a high fever, painful parotid swelling and dull pain in the upper abdomen with eleva...

journal_title：Clinical endocrinology

authors： Taguchi M,Yokota M,Koyano H,Endo Y,Ozawa Y

更新日期：1999-11-01 00:00:00

abstract：CONTEXT:Animal data and cross-sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute hyponatraemia on bone turnover have not been determined. Our objective was to test the hypothesis that acute hyponatraemia leads to dynamic effects on bone turnover. DESIG...

journal_title：Clinical endocrinology

authors： Garrahy A,Galloway I,Hannon AM,Dineen R,Javadpour M,Tormey WP,Gan KJ,Twomey PJ,Mc Kenna MJ,Kilbane M,Crowley RK,Sherlock M,Thompson CJ

更新日期：2020-11-11 00:00:00

abstract：:A radioimmunoassay (RIA) procedure was devised for the estimation of PRL in eluates of dried whole blood from filter paper. Levels of PRL were measured in newborn blood obtained during the first week of life from 530 infants of normal birthweight (greater than 2500 g) with normal T4 values, 114 infants of normal birth...

journal_title：Clinical endocrinology

authors： Mitchell ML,Hermos RJ,Bennett JE,McKenna JJ,Mitchell EL

更新日期：1986-01-01 00:00:00

abstract：:Polyglandular syndromes have been described for many years but only one case of panhypopituitarism with adrenal and thyroid insufficiencies has been documented. We present a 69-year-old woman with the initial diagnosis of idiopathic primary hypopituitarism. An associated primary adrenal disease was suspected on low pl...

journal_title：Clinical endocrinology

authors： Pholsena M,Young J,Couzinet B,Schaison G

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The immediate early gene locus AP-1, incorporating the cellular oncogenes c-fos and c-jun (and their oncoprotein products Fos and Jun respectively) play a key role in regulating cell growth and differentiation. The myc-gene is also known to promote cell growth. In order to investigate the possible ...

journal_title：Clinical endocrinology

authors： Raghavan R,Harrison D,Ince PG,James RA,Daniels M,Birch P,Caldwell GI,Kendall-Taylor P

更新日期：1994-01-01 00:00:00

abstract：:Thyroid status was estimated serially by measuring triiodothyronine (T3), thyroxine (T4) and thyrotrophin (hTSH) in 20 patients suffering from meningococcal meningitis, typhoid fever and other acute febrile illnesses. Significantly low T3 and only slightly increased T4 were observed in all the patients. hTSH was norma...

journal_title：Clinical endocrinology

authors： Maharajan G,Etta KM,Singh A,Ahuja IS,Ahuja GK

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:To define and discuss the changes of important risk factors and TNM staging over the last 40 years in patients operated on for differentiated thyroid carcinoma (DTC), resulting from the introduction of newer sensitive diagnostic procedures in the preoperative evaluation of thyroid nodules. PATIENTS:We review...

journal_title：Clinical endocrinology

authors： Karga H,Mavroudis K,Giagourta I,Triantaphyllopoulou M,Ktena V,Kassi G,Veloutsou H,Papapetrou P

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to elucidate the parathyroid responsiveness by measurements of blood ionized calcium and serum intact parathyroid hormone (PTH) concentrations, before and during trisodium citrate induced hypocalcaemia. PATIENTS AND CONTROLS:Sixteen patients with primary hyperparathyroi...

journal_title：Clinical endocrinology

authors： Schwarz P,Sørensen HA,Momsen G,McNair P,Transbøl I

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Constitutional delay of growth and puberty (CDGP) is a tempo variant with a good prognosis. Healthy late-maturing adolescents grow slower than postulated by age-related references, and therefore, CDGP is frequently confused with growth hormone deficiency (GHD). For differential diagnosis, height velocity refe...

journal_title：Clinical endocrinology

authors： Binder G,Lehrian TJ,Hoffmann E,Blumenstock G,Rahmaoui A,Trzaskoma B,Reinehr T

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Mutations in the melanocortin-4 receptor gene (MC4R) are the most common monogenic form of human obesity. However, the contribution of MC4R mutations to obesity in Chinese has not been investigated. We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequen...

journal_title：Clinical endocrinology

authors： Rong R,Tao YX,Cheung BM,Xu A,Cheung GC,Lam KS

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate whether the absence of increased 5 alpha-reductase activity explained the absence of hirsutism in premenopausal obese women with increased free testosterone (FT) levels. DESIGN:As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase act...

journal_title：Clinical endocrinology

authors： Giagulli VA,De Pergola G,Giorgino F,Cignarelli M,Abbaticchio G,Vermeulen A,Giorgino R

更新日期：1992-06-01 00:00:00

abstract：INTRODUCTION:Prader-Willi syndrome (PWS) is a genetic disorder caused by the loss of expression of paternally transcribed genes in a highly imprinted region of chromosome 15q11-13. The clinical phenotype has been well characterized, mostly related to hypothalamic dysfunction. Even though central hypothyroidism has been...

journal_title：Clinical endocrinology

authors： Vaiani E,Herzovich V,Chaler E,Chertkoff L,Rivarola MA,Torrado M,Belgorosky A

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Low growth hormone (GH) secretion and hypogonadism are common in patients with Prader-Willi syndrome (PWS). In this study we present the effects of GH treatment on body composition and metabolism in adults with PWS. PATIENTS AND MEASUREMENTS:Nineteen patients with clinical PWS were recruited, 13 had PWS geno...

journal_title：Clinical endocrinology

authors： Höybye C,Hilding A,Jacobsson H,Thorén M

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:We examined the effect of GH substitution on adipose tissue-derived hormones and cytokines and sought to identify predictors for changes in body composition during therapy. Long-standing adult-onset GH deficiency (AO-GHD) is associated with increased body fat mass (FM) which, through production of hormones an...

journal_title：Clinical endocrinology

authors： Ueland T,Jørgensen AP,Godang K,Fougner KJ,Aukrust P,Burman P,Bollerslev J

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective...

journal_title：Clinical endocrinology

authors： Celi FS,Zemskova M,Linderman JD,Babar NI,Skarulis MC,Csako G,Wesley R,Costello R,Penzak SR,Pucino F

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF-like repeat-containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc-dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower insulin sensitivity. Dlk1-def...

journal_title：Clinical endocrinology

authors： Hermida C,Garcés C,de Oya M,Cano B,Martínez-Costa OH,Rivero S,García-Ramírez JJ,Laborda J,Aragón JJ

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) is a marker of residual differentiated thyroid cancer (DTC) after total thyroidectomy; however, circulating antithyroglobulin antibodies (TgAb) may interfere with the immunoassay for Tg. Ultrasensitive assays may have a more significant role in detecting circulating Tg in the context ...

journal_title：Clinical endocrinology

authors： McGrath RT,Preda VA,Clifton-Bligh P,Robinson B,Sywak M,Delbridge L,Ward P,Clifton-Bligh RJ,Learoyd DL

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Controversial data on ghrelin concentration during exercise in human subjects have been published. We tested the hypothesis that exercise could affect acylated ghrelin (AG) and unacylated ghrelin (UAG), which could partly explain the previously reported inconsistent findings on the association of exercise wit...

journal_title：Clinical endocrinology

authors： Kim HJ,Lee S,Kim TW,Kim HH,Jeon TY,Yoon YS,Oh SW,Kwak H,Lee JG

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The resistance of macroprolactinomas to dopamine agonist (DA) therapy, whether defined as an absence of PRL normalization or the lack of significant tumour shrinkage after prolonged treatment at high doses, is usually regarded as unpredictable. The aim of this retrospective study, conducted in a te...

journal_title：Clinical endocrinology

authors： Delgrange E,Duprez T,Maiter D

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:The LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases. However, there have been no previous reports on the ...

journal_title：Clinical endocrinology

authors： Liang H,Murase Y,Katuta Y,Asano A,Kobayashi J,Mabuchi H

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:With increasing use of computed tomography and magnetic resonance imaging, pituitary adenomas are being discovered incidentally with increasing frequency. However, limited data are available concerning the clinical importance and natural history of such 'incicentalomas'. We have undertaken a prospective study...

journal_title：Clinical endocrinology

authors： Feldkamp J,Santen R,Harms E,Aulich A,Mödder U,Scherbaum WA

更新日期：1999-07-01 00:00:00

abstract：:The age-dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in the elderly by their effects on muscle mass and bone mineral density. However, for healthy men data on serum oestrogens and androgens, as well as IGF-1, as a common outcome measure covering the whole adult age range ar...

journal_title：Clinical endocrinology

authors： Leifke E,Gorenoi V,Wichers C,Von Zur Mühlen A,Von Büren E,Brabant G

更新日期：2000-12-01 00:00:00

abstract：:A 32-year-old Caucasian male, clinically euthyroid, with paranoid schizophrenia and granulocytopenia, had elevated total and free serum T4 and T3; serum TSH was normal (2.7 +/- 0.7 micronU/ml). There was no goitre present, no evidence of Graves' disease, and no evidence of pituitary tumour. He had a normal response to...

journal_title：Clinical endocrinology

authors： Tamagna EI,Carlson HE,Hershman JM,Reed AW

更新日期：1979-05-01 00:00:00

abstract：INTRODUCTION:Evidence of crosstalk between bone and insulin metabolism has been identified. In primary hyperparathyroidism (PHPT), scant data exist on this relationship. AIM:To evaluate the relationship between insulin levels or sensitivity and bone mineral density (BMD) in PHPT. SUBJECT AND METHODS:Two hundred and s...

journal_title：Clinical endocrinology

authors： Gianotti L,Tassone F,Baffoni C,Pellegrino M,Cassibba S,Castellano E,Magro G,Cesario F,Visconti G,Borretta G

更新日期：2014-09-01 00:00:00

abstract：:The purpose of this study was to assess the normal relationship between plasma ACTH and cortisol during insulin induced hypoglycaemia. Twenty-six healthy persons were studied. Peak plasma concentration and the amounts of ACTH and cortisol secreted during hypoglycaemia were compared. There was no significant correlatio...

journal_title：Clinical endocrinology

authors： Lindholm J,Kehlet H,Blichert-Toft M,Riishede J,Hummer L,Dinesen B

更新日期：1978-10-01 00:00:00