Relationship between insulin sensitivity and bone mineral density in primary hyperparathyroidism.

Abstract:

INTRODUCTION:Evidence of crosstalk between bone and insulin metabolism has been identified. In primary hyperparathyroidism (PHPT), scant data exist on this relationship. AIM:To evaluate the relationship between insulin levels or sensitivity and bone mineral density (BMD) in PHPT. SUBJECT AND METHODS:Two hundred and sixty-seven patients with PHPT without known diabetes mellitus were studied. Fasting blood glucose and insulin levels as well as BMD at lumbar spine, femoral neck and forearm were measured. Insulin sensitivity was assessed using Quantitative Insulin Sensitivity Check Index (QUICKI). The same parameters were measured 2 years (interquartile range 2·8 years) after surgery (PTX) in a subgroup of patients (n = 51). RESULTS:In univariate analysis, a positive relationship between insulin levels and BMD (R = 0·17, P < 0·03) or T-score (R = 0·20, P < 0·005) was found at femoral neck level. Consequently, a negative relationship between QUICKI and femoral BMD (R = -0·20, P < 0·01) or T-score (R = -0·21, P < 0·004) was found. In multivariate analysis, when femoral BMD was the dependent variable, age (beta = -0·35, P < 0·000004), BMI (beta = 0·39, P < 0·00001), PTH (beta = -0·18, P < 0·05) and QUICKI (R = -0·15, P < 0·05) had an independent effect (R(2) = 0·29). Insulin levels and QUICKI did not change after PTX. No relationship was found between QUICKI or insulin levels at the time of diagnosis and change in BMD at any site at follow-up. CONCLUSIONS:Our data show a weak relationship between insulin levels and/or insulin sensitivity and BMD in PHPT. However, the insulin state does not influence change in bone density after PTX in PHPT.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Gianotti L,Tassone F,Baffoni C,Pellegrino M,Cassibba S,Castellano E,Magro G,Cesario F,Visconti G,Borretta G

doi

10.1111/cen.12472

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

350-5

issue

3

eissn

0300-0664

issn

1365-2265

journal_volume

81

pub_type

杂志文章
  • Treatment of malignant phaeochromocytoma with a combination of cyclophosphamide, vincristine and dacarbazine: own experience and overview of the contemporary literature.

    abstract:OBJECTIVE:Malignant phaeochromocytomas are rare and highly aggressive tumours. This retrospective study evaluated the outcome of combined chemotherapy with cyclophosphamide, vincristine and dacarbazine (also known as CVD regimen). METHODS:Patients with histologically and radiologically confirmed malignant phaeochromoc...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12590

    authors: Deutschbein T,Fassnacht M,Weismann D,Reincke M,Mann K,Petersenn S

    更新日期:2015-01-01 00:00:00

  • Identification of the first germline HRPT2 whole-gene deletion in a patient with primary hyperparathyroidism.

    abstract:OBJECTIVE:Germline mutations in the HRPT2 gene are associated with the hereditary hyperparathyroidism-jaw tumour syndrome (HPT-JT) and a subset of familial isolated hyperparathyroidism (FIHP). Somatic HRPT2 mutations are detected in sporadic parathyroid carcinomas and less frequently in cystic adenomas. The purpose of ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2011.04184.x

    authors: Domingues R,Tomaz RA,Martins C,Nunes C,Bugalho MJ,Cavaco BM

    更新日期:2012-01-01 00:00:00

  • Predictive factors related to the recurrence at US-guided fine needle aspiration in postoperative patients with differentiated thyroid cancer.

    abstract:OBJECTIVES:The recent American Thyroid Association management guidelines suggest cervical ultrasonography (US) surveillance in patients with differentiated thyroid cancer (DTC). This study was conducted to identify predictive factors that can determine whether subsequent fine needle aspiration guided by ultrasound (US-...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2010.03915.x

    authors: Hahn SY,Shin JH,Han BK,Ko EY,Kang SS,Chung JH,Kim JH,Oh YL,Son YI

    更新日期:2011-02-01 00:00:00

  • A novel PRKAR1A mutation associated with hepatocellular carcinoma in a young patient and a variable Carney complex phenotype in affected subjects in older generations.

    abstract:CONTEXT:Carney complex (CNC) is an autosomal dominant multiple endocrine neoplasia syndrome (OMIM 160980). About 70% of cases are familiar; most have mutations of the PRKAR1A gene on chromosome 17q22-24. There is little phenotype-genotype correlation known to date. OBJECTIVE:To study the genotype-phenotype correlation...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2008.03286.x

    authors: Gennari M,Stratakis CA,Hovarth A,Pirazzoli P,Cicognani A

    更新日期:2008-11-01 00:00:00

  • Cytokine expression in human anterior pituitary adenomas.

    abstract:OBJECTIVE:There is increasing evidence for the role of cytokines in pituitary differentiated function and tumorigenesis, but the spectrum of cytokines found in the pituitary is unknown. Therefore profiles of cytokine expression were determined in different human anterior pituitary adenoma sub-types. DESIGN:The reverse...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1996.d01-1554.x

    authors: Green VL,Atkin SL,Speirs V,Jeffreys RV,Landolt AM,Mathew B,Hipkin L,White MC

    更新日期:1996-08-01 00:00:00

  • Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.

    abstract:BACKGROUND:Distinguishing malignant thyroid nodules in patients with follicular cytology by fine-needle aspiration (FNA) remains problematic. The large majority of thyroid nodules (> 85%) are overtreated. Therefore, a clear need exists to develop more accurate initial diagnostic tests for follicular thyroid nodules. Ga...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2007.03031.x

    authors: Hooft L,van der Veldt AA,Hoekstra OS,Boers M,Molthoff CF,van Diest PJ

    更新日期:2008-02-01 00:00:00

  • The sulpiride test in panhypopituitarism.

    abstract::The results obtained with a new test of prolactin (PRL) release in six panhypopituitary patients as compared to fourteen normal subjects (eight females and six males) are presented. The test consists of the i.m. administration of 100 mg of sulpiride and the measurement of plasma PRL by a double antibody radioimmunoass...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1978.tb01494.x

    authors: Batrinos ML,Pavlou SN,Pitoulis SA,Sfikaki AP,Alexandrides TK,Piaditis GP

    更新日期:1978-03-01 00:00:00

  • Ghrelin and growth hormone (GH) secretagogue receptor (GHSR) mRNA expression in human pituitary adenomas.

    abstract:OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.2001.01286.x

    authors: Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

    更新日期:2001-06-01 00:00:00

  • Features of papillary thyroid microcarcinoma associated with lateral cervical lymph node metastasis.

    abstract:OBJECTIVES:Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the pre-operative features of PTMC associated with LCLN meta...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13322

    authors: Jeon MJ,Chung MS,Kwon H,Kim M,Park S,Baek JH,Song DE,Sung TY,Hong SJ,Kim TY,Kim WB,Shong YK,Lee JH,Kim WG

    更新日期:2017-06-01 00:00:00

  • Parathyroid hormone and parathyroid hormone-related protein in the investigation of hypercalcaemia in two hospital populations.

    abstract:BACKGROUND AND OBJECTIVE:Parathyroid hormone-related protein (PTHrP) produced by cancers has a central role as a humoral mediator of hypercalcaemia in patients with malignancy. Since the prevalences of hypercalcaemia of malignancy and parathyroid disease reflect the population studied, hypercalcaemic patients from a di...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2265.1994.tb02569.x

    authors: Walls J,Ratcliffe WA,Howell A,Bundred NJ

    更新日期:1994-10-01 00:00:00

  • Abnormal pubertal development in primary hypothyroidism.

    abstract::We have studied three patients (1M, 2F), age range 10.9 to 15.5 years, who had abnormal sexual maturation secondary to primary hypothyroidism. The boy had inappropriately large testes for his stage of puberty, the girls had isolated breast development and there was absence of pubertal growth acceleration. FSH, LH, TSH...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1988.tb03682.x

    authors: Pringle PJ,Stanhope R,Hindmarsh P,Brook CG

    更新日期:1988-05-01 00:00:00

  • Influence of parasellar extension of macroprolactinomas defined by magnetic resonance imaging on their responsiveness to dopamine agonist therapy.

    abstract:OBJECTIVE AND DESIGN:The resistance of macroprolactinomas to dopamine agonist (DA) therapy, whether defined as an absence of PRL normalization or the lack of significant tumour shrinkage after prolonged treatment at high doses, is usually regarded as unpredictable. The aim of this retrospective study, conducted in a te...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2006.02493.x

    authors: Delgrange E,Duprez T,Maiter D

    更新日期:2006-04-01 00:00:00

  • Persistence of Müllerian ducts in male pseudohermaphroditism, and its relationship to cryptorchidism.

    abstract::Twenty-two cases of male pseudohermaphroditism with persistence of Müllerian duct derivatives were reviewed. In 12 cases of mixed gonadal dysgenesis and five cases of dysgenetic male pseudohermaphroditism, testosterone-dependent steps of sex differentiation were also impaired, and testicular dysgenesis was prominent, ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1983.tb02987.x

    authors: Josso N,Fekete C,Cachin O,Nezelof C,Rappaport R

    更新日期:1983-08-01 00:00:00

  • Increasing thyroid cancer incidence in Queensland, Australia 1982-2008 - true increase or overdiagnosis?

    abstract:BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12724

    authors: Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

    更新日期:2016-02-01 00:00:00

  • A new and distinctive albumin variant with increased affinities for both triiodothyronines and causing hyperthyroxinaemia.

    abstract::A new variant albumin with increased affinities for iodothyronines has been identified. A euthyroid woman had raised total serum concentrations of T4 (155 nmol/l), T3 (3.0 nmol/l) and rT3 (700 pmol/l) but normal levels of all three iodothyronine-binding proteins. The affinity constant for T3 binding to the albumin was...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1985.tb00152.x

    authors: Lalloz MR,Byfield PG,Himsworth RL

    更新日期:1985-04-01 00:00:00

  • Thyroid function in short children born small-for-gestational age (SGA) before and during GH treatment.

    abstract:CONTEXT:Disturbances in thyroid function have been described in small-for-gestational age (SGA) children but the influence of prematurity is unclear. In addition, the effect of GH treatment on thyroid function has not been studied in short SGA children. OBJECTIVES:To determine whether short SGA children have higher TS...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2008.03195.x

    authors: de Kort SW,Willemsen RH,van der Kaay DC,van Dijk M,Visser TJ,Hokken-Koelega AC

    更新日期:2008-08-01 00:00:00

  • Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene.

    abstract:UNLABELLED:A diagnosis of bilateral pheochromocytoma warrants exclusion of hereditary pheochromocytoma. OBJECTIVE:To describe the first case of a bilateral pheochromocytoma associated with V804M mutation in the RET proto-oncogene. PATIENTS:The index case was a 54-year-old man with bilateral adrenal masses discovered ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2007.02830.x

    authors: Recasens M,Oriola J,Fernández-Real JM,Roig J,Rodríguez-Hermosa JI,Font JA,Galofre P,López-Bermejo A,Ricart W

    更新日期:2007-07-01 00:00:00

  • Insulin-like growth factor-I raises serum procollagen levels in children and adults with Laron syndrome.

    abstract:OBJECTIVE:Recombinant IGF-I is now available for the treatment of GH insensitivity (Laron syndrome). We have determined the effects of IGF-I on soft connective tissue and bone metabolism in a group of patients with this disorder. PATIENTS AND DESIGN:Thirteen patients with Laron syndrome (LS) (8 children and 5 adults) ...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2265.1996.7990809.x

    authors: Klinger B,Jensen LT,Silbergeld A,Laron Z

    更新日期:1996-10-01 00:00:00

  • Detection of autoantibodies to recombinant human thyroid peroxidase by sensitive enzyme immunoassay.

    abstract::Autoantibodies to thyroid peroxidase (TPO), the thyroid 'microsomal' antigen, are widely utilized in the diagnosis of human autoimmune thyroid disease. Crude human thyroid preparations of TPO are of differing potency, contain residual thyroglobulin (Tg) and other human membrane antigens, and are available in only limi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1990.tb03912.x

    authors: Kendler DL,Martin A,Magnusson RP,Davies TF

    更新日期:1990-12-01 00:00:00

  • Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method.

    abstract:OBJECTIVES:We have demonstrated previously that obesity in men was significantly associated with low plasma testosterone levels and higher concentrations of the androgen metabolite androstane-3 alpha, 17 beta-diol glucuronide, suggesting that androgen metabolism and elimination is increased in this condition. The objec...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1999.00709.x

    authors: Tchernof A,Lévesque E,Beaulieu M,Couture P,Després JP,Hum DW,Bélanger A

    更新日期:1999-05-01 00:00:00

  • Thyroid scintigraphy in the era of fine-needle aspiration cytology.

    abstract:PURPOSE:To evaluate whether thyroid scintigraphy would alter the clinical management of patients referred for fine-needle aspiration cytology (FNA). METHODS:We reviewed the medical and imaging records of patients referred to our Department between 2016 and 2019. All the patients had to take a serum thyrotropin test ad...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.14379

    authors: Pirola I,Di Lodovico E,Casella C,Pezzaioli L,Facondo P,Ferlin A,Lombardi D,Cappelli C

    更新日期:2020-12-17 00:00:00

  • Treatment of post-menopausal osteoporosis with a combination of growth hormone and pamidronate: a placebo controlled trial.

    abstract:OBJECTIVE:It is known that growth hormone can induce accelerated bone turnover in GH deficient people as well as healthy elderly people. In this study we examined the effect of recombinant human GH (rhGH) on bone mineral mass and bone turnover in the presence of the bone resorption inhibiting agent, pamidronate. Effect...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1995.tb02920.x

    authors: Erdtsieck RJ,Pols HA,Valk NK,van Ouwerkerk BM,Lamberts SW,Mulder P,Birkenhäger JC

    更新日期:1995-11-01 00:00:00

  • Effect of calcitonin on gastrointestinal regulatory peptides in man.

    abstract::A major physiological role of calcitonin in humans appears to be regulation of skeletal turnover. It has been suggested that another function of calcitonin is to prevent post-prandial rises in calcium, particularly in animals, but the importance of such a function in man remains to be determined. Although it is known ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1985.tb03002.x

    authors: Stevenson JC,Adrian TE,Christofides ND,Bloom SR

    更新日期:1985-05-01 00:00:00

  • Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis.

    abstract:BACKGROUND:The prognostic value of the telomerase reverse transcriptase (TERT) promoter mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma (PTC), has been generally confirmed. To data, there is no high-level evidence approving the association of TERT promoter mutation and aggressive clinical b...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/cen.13017

    authors: Yin DT,Yu K,Lu RQ,Li X,Xu J,Lei M,Li H,Wang Y,Liu Z

    更新日期:2016-08-01 00:00:00

  • The relationship between hCG and relaxin secretion in normal pregnancies vs peri-implantation spontaneous abortions.

    abstract:OBJECTIVE:We determined the ovarian response to human chorionic gonadotrophin (hCG) in terms of relaxin and progesterone secretion during the peri-implantation period of normal and failing pregnancies. We wished to test the hypotheses that relaxin production in failing pregnancies is different from that in normal pregn...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1993.tb00518.x

    authors: Stewart DR,Overstreet JW,Celniker AC,Hess DL,Cragun JR,Boyers SP,Lasley BL

    更新日期:1993-04-01 00:00:00

  • Studies in constitutionally tall adolescents: somatostatin decrease associated with growth hormone increase after TRH injection.

    abstract::The paradoxical GH response to TRH observed in certain adolescents with constitutional tall stature is associated with a 60% fall in plasma levels of somatostatin. Conversely, those tall subjects who do not show a GH increase after TRH, or during a saline control infusion maintain steady levels of somatostatin in plas...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1984.tb03232.x

    authors: Garcia Blanco M,Evain Brion D

    更新日期:1984-10-01 00:00:00

  • Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children?

    abstract::Nutrition and growth during infancy are an emerging issue because of their potential link to metabolic health disorders in later life. Moreover, prolonged breast-feeding appears to be associated with a lower risk of obesity than formula feeding. Human milk is a source of various hormones and growth factors, namely adi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2265.2009.03585.x

    authors: Savino F,Fissore MF,Liguori SA,Oggero R

    更新日期:2009-12-01 00:00:00

  • Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience.

    abstract:BACKGROUND:A number of surgical series have been reported on the treatment of acromegaly and their results vary widely. The acceptable definition of remission has changed in recent years and it is known, though in a small series, that growth hormone levels of > 5 mU/l are still associated with an increased mortality fr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1999.00760.x

    authors: Ahmed S,Elsheikh M,Stratton IM,Page RC,Adams CB,Wass JA

    更新日期:1999-05-01 00:00:00

  • The response of plasma oxytocin to surgical stress.

    abstract::Recent evidence suggests that oxytocin (OXT) and arginine vasopressin (AVP) are involved in the response to stress. We have examined the changes in peripheral plasma OXT during abdominal surgery in eight patients (six males, two female; ages 60-82 years) undergoing hemicolectomy and compared the results with those for...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1988.tb01213.x

    authors: Nussey SS,Page SR,Ang VT,Jenkins JS

    更新日期:1988-03-01 00:00:00

  • Novel risk factors for hospital-acquired hyponatraemia: a matched case-control study.

    abstract:BACKGROUND:Hospital-acquired hyponatraemia is a common and potentially serious condition. Risk factors for hospital-acquired hyponatraemia have not been studied in a controlled fashion. Methods From 1501 patients in whom serum sodium (S(Na)) was determined, 50 cases with hospital-acquired hyponatraemia (in-hospital dec...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2007.02741.x

    authors: Beukhof CM,Hoorn EJ,Lindemans J,Zietse R

    更新日期:2007-03-01 00:00:00