当前位置： SCI文献检索 > CLINICAL ENDOCRINOLOGY期刊下所有文献 > Inhibin B plus LH vs GnRH agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys.

Inhibin B plus LH vs GnRH agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys.

Abstract：

OBJECTIVE:The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in comparison with inhibin B alone or in combination with basal LH for the diagnosis of IHH. PATIENTS AND MEASUREMENTS:Ninety-seven prepubertal males aged 13·7-17·5 year, with testicular volumes ≤4 ml, were examined every 6 months. CDGP was defined by a testicular volume ≥8 ml after 18 months, and IHH was defined by a testicular volume <5 ml after 24 months follow-up. Inhibin B concentrations were measured by ELISA, and LH concentrations were measured by CLIA. RESULTS:At follow-up, the cohort comprised 52 boys with CDGP and nine with IHH. The other patients were lost for follow-up (n = 10), had not reached follow-up yet (n = 20) or did not reach a definite testicular volume (n = 6). Basal LH <0·3 IU/l, stimulated LH (4 h) <5·3 IU/l or inhibin B <111 pg/ml had 100% sensitivity for IHH. Only LH (4 h) <5·3 IU/l had a specificity of 100%, and the specificities of basal LH <0·3 IU/l (88%) or inhibin B <110 pg/ml (92%) were lower. The combination of LH <0·3 IU/l with inhibin B <111 pg/ml increased the specificity to 98·1%. CONCLUSIONS:The LH response 4 h after GnRH agonist stimulation has an excellent accuracy for the diagnosis of IHH in prepubertal boys with delayed puberty. However, the measurement of inhibin B and basal LH in combination is a valid, reliable and less-invasive alternative test.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Binder G,Schweizer R,Blumenstock G,Braun R

doi

10.1111/cen.12613

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

100-5

issue

1

eissn

0300-0664

issn

1365-2265

journal_volume

82

pub_type

杂志文章

相关文献

CLINICAL ENDOCRINOLOGY文献大全
  • No overrepresentation of congenital adrenal hyperplasia in patients with adrenocortical tumours.

    abstract：OBJECTIVE:The development and progression of sporadic adrenocortical tumours are poorly understood. In autopsy studies adrenocortical tumours are found in between 2 and 9% of the general population. In congenital adrenal hyperplasia (CAH), decreased production of cortisol leads to increased secretion of ACTH from the p...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1999.00655.x

    authors： Kjellman M,Holst M,Bäckdahl M,Larsson C,Farnebo LO,Wedell A

    更新日期：1999-03-01 00:00:00

  • The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves' ophthalmopathy--support for a role of autoimmunity against calsequestrin as the triggering event.

    abstract：BACKGROUND:Graves' Ophthalmopathy (GO) is a complex eye and orbital disorder that is uniquely linked to Graves' Hyperthyroidism (GH) and has traditionally been considered a cross-reactive immune response against the thyroid stimulating hormone receptor (TSHR) in orbital tissue. However, because there is no direct evide...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2009.03753.x

    authors： Wescombe L,Lahooti H,Gopinath B,Wall JR

    更新日期：2010-10-01 00:00:00

  • Radiation and neuroregulatory control of growth hormone secretion.

    abstract：OBJECTIVE:Cranial irradiation frequently results in growth hormone (GH) deficiency. Patients with radiation-induced GH deficiency usually remain responsive to exogenous growth hormone releasing hormone, implying radiation damages the hypothalamus rather than the pituitary. Little is known about the effect of cranial ir...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1994.tb02525.x

    authors： Ogilvy-Stuart AL,Wallace WH,Shalet SM

    更新日期：1994-08-01 00:00:00

  • Lymphocytic traffic and homing into target tissue and the generation of endocrine autoimmunity.

    abstract：:Endocrine autoimmunity is known to be characterized by the presence of specific autoantibodies and from the histopathological point of view by lymphocytic infiltration in the target tissue. The presence of mononuclear cell infiltrates is the pathological hallmark of most endocrine diseases characterized by an autoimmu...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2265.1994.tb01816.x

    authors： Pozzilli P,Carotenuto P,Delitala G

    更新日期：1994-11-01 00:00:00

  • An improved mathematical model of human thyroid hormone regulation.

    abstract：:1. A mathematical model has been constructed of human thyroid hormone regulation by the anterior pituitary gland, which takes account of most of the currently available experimental data. 2. Successful simulation of data on the stimulation of thyrotrophin (TSH) secretion by thyrotrophin releasing hormone (TRH) was ach...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1976.tb01976.x

    authors： Saratchandran P,Carson ER,Reeve J

    更新日期：1976-09-01 00:00:00

  • Growth in children with craniopharyngioma following surgery.

    abstract：OBJECTIVE:Hypopituitarism, including severe GH deficiency, is an almost inevitable outcome of craniopharyngioma. However, some GH deficient children with this tumour may grow normally or even have accelerated growth postoperatively. To study this phenomenon we have investigated the endocrine status, including IGF-1 and...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1998.00590.x

    authors： Tiulpakov AN,Mazerkina NA,Brook CG,Hindmarsh PC,Peterkova VA,Gorelyshev SK

    更新日期：1998-12-01 00:00:00

  • Menstrual function and serum prolactin levels after long-term bromocriptine treatment of hyperprolactinaemic amenorrhoea.

    abstract：:Long-term bromocriptine treatment was discontinued in thirty-seven women with hyperprolactinaemic amenorrhoea. After cessation of therapy thirty of the thirty-seven women became hyperprolactinaemic again with amenorrhoea or anovulatory bleeding. Seven of the women continued to have regular ovulatory menstruation but o...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1982.tb03175.x

    authors： Bergh T,Nillius SJ,Wide L

    更新日期：1982-06-01 00:00:00

  • The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids.

    abstract：OBJECTIVE:We assessed the relative risk of both serum TSH and antithyroid antibody concentrations with regard to progression of thyroid failure and studied the lipid profiles of individuals with elevated TSH levels. DESIGN, PATIENTS AND MEASUREMENTS:In a randomly selected group of 427 women aged 40-60 (mean 55) years ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1993.tb02366.x

    authors： Geul KW,van Sluisveld IL,Grobbee DE,Docter R,de Bruyn AM,Hooykaas H,van der Merwe JP,van Hemert AM,Krenning EP,Hennemann G

    更新日期：1993-09-01 00:00:00

  • The effect of minor increments in plasma thyroxine on heart rate and urinary sodium excretion.

    abstract：:We studied day/night (D:N) patterns of urinary sodium excretion and the 24 hour ambulatory electrocardiogram in seven normal subjects before and during the administration of T4. Thyroxine increased thyroid hormone levels within the normal range and inhibited the plasma TSH response to TRH. This was associated with a s...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1983.tb02881.x

    authors： Bell GM,Sawers JS,Forfar JC,Doig A,Toft AD

    更新日期：1983-05-01 00:00:00

  • Evaluation of bone mineral density of the peripheral skeleton in pre- and postmenopausal women with newly diagnosed endogenous Cushing's syndrome.

    abstract：OBJECTIVE:Cushing's syndrome (CS) is a well recognized cause of bone loss. Although many previous studies have shown decreased bone mineral density (BMD) in the lumbar spina and proximal femur of patients with endogenous CS, so far, the data estimating BMD in their peripheral skeleton are sparse. The aim of the present...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2004.01968.x

    authors： Karavitaki N,Ioannidis G,Giannakopoulos F,Mavrokefalos P,Thalassinos N

    更新日期：2004-02-01 00:00:00

  • Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children.

    abstract：OBJECTIVE:Controversial data on ghrelin concentration during exercise in human subjects have been published. We tested the hypothesis that exercise could affect acylated ghrelin (AG) and unacylated ghrelin (UAG), which could partly explain the previously reported inconsistent findings on the association of exercise wit...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2265.2007.03058.x

    authors： Kim HJ,Lee S,Kim TW,Kim HH,Jeon TY,Yoon YS,Oh SW,Kwak H,Lee JG

    更新日期：2008-03-01 00:00:00

  • IGF-I in a normal population: relation to psychosocial factors.

    abstract：OBJECTIVE:IGF-I has important actions on cell division, apoptosis, differentiation and metabolism, as well as on cell proliferation in vascular smooth muscle. Deficiency of GH, an important regulator of IGF-I, is associated with reduced well-being. IGF-I levels have been related to cognitive function in older individua...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.2002.01671.x

    authors： Unden AL,Elofsson S,Knox S,Lewitt MS,Brismar K

    更新日期：2002-12-01 00:00:00

  • Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity.

    abstract：OBJECTIVE:Hypothalamic-pituitary-adrenal axis (HPA) activity is decreased in obese pregnancy and associates with increased foetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal foetal growth, but little is known about glucocorticoid ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13548

    authors： Stirrat LI,Walker JJ,Stryjakowska K,Jones N,Homer NZM,Andrew R,Norman JE,Lightman SL,Reynolds RM

    更新日期：2018-04-01 00:00:00

  • Ontogeny of foetal exposure to maternal cortisol using midtrimester amniotic fluid as a biomarker.

    abstract：OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2007.02785.x

    authors： Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

    更新日期：2007-05-01 00:00:00

  • Autonomous cortisol secretion in adrenal incidentalomas and increased visceral fat accumulation during follow-up.

    abstract：OBJECTIVE:Autonomous cortisol secretion of adrenal incidentalomas (AIs) is associated with poor cardiovascular outcome. Because centripetal obesity is a cardiovascular risk factor, we aimed to investigate whether autonomous cortisol secretion is associated with increased visceral fat accumulation. DESIGN:Retrospective...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13408

    authors： Yener S,Baris M,Peker A,Demir O,Ozgen B,Secil M

    更新日期：2017-11-01 00:00:00

  • Inhibin B levels in azoospermic subjects with cytologically characterized testicular pathology.

    abstract：BACKGROUND AND OBJECTIVE:Inhibin B, a heterodimeric glycoprotein of gonadal origin, is the most important circulating form of inhibin in human males and an inverse relationship between inhibin B and FSH plasma levels was been recently observed. Azoospermia represents the end-point of different kinds of testicular damag...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1999.00659.x

    authors： Foresta C,Bettella A,Petraglia F,Pistorello M,Luisi S,Rossato M

    更新日期：1999-06-01 00:00:00

  • Small, dense low-density lipoproteins (LDL) are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome.

    abstract：OBJECTIVE:Small, dense low-density lipoproteins (LDL) are a feature of the metabolic syndrome (MS) but their predictive role still remains to be established. We performed a 2-year follow-up study in 124 subjects with MS (63 +/- 6 years), as defined by the American Heart Association/National Heart, Lung and Blood Instit...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2008.03407.x

    authors： Rizzo M,Pernice V,Frasheri A,Di Lorenzo G,Rini GB,Spinas GA,Berneis K

    更新日期：2009-06-01 00:00:00

  • Thyroid function in choriocarcinoma: demonstration of a thyroid stimulating activity in serum using FRTL-5 and human thyroid cells.

    abstract：:Hyperthyroidism is a well recognized complication of gestational trophoblastic tumours (GTT) and may be due to high circulating concentrations of human chorionic gonadotrophin (hCG) or its variants. We have studied 24 clinically euthyroid women with GTT. Eight were biochemically hyperthyroid with low or undetectable s...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1990.tb00487.x

    authors： Kennedy RL,Sheridan E,Darne J,Griffiths H,Davies R,Price A,Cohn M

    更新日期：1990-08-01 00:00:00

  • Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men.

    abstract：OBJECTIVE:Sex steroid hormones influence bone mineral density (BMD) in women, but are less well-studied in men. We evaluated the association of serum total and free sex steroid hormones and SHBG with osteopaenia in a nationally representative sample of men aged 20-90 years. DESIGN:BMD and sex steroid hormones were mea...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2008.03300.x

    authors： Paller CJ,Shiels MS,Rohrmann S,Basaria S,Rifai N,Nelson W,Platz EA,Dobs A

    更新日期：2009-01-01 00:00:00

  • Exploring the spectrum of 3-M syndrome, a primordial short stature disorder of disrupted ubiquitination.

    abstract：:3-M syndrome is an autosomal recessive primordial growth disorder characterized by small birth size and post-natal growth restriction associated with a spectrum of minor anomalies (including a triangular-shaped face, flat cheeks, full lips, short chest and prominent fleshy heels). Unlike many other primordial short st...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2265.2012.04428.x

    authors： Clayton PE,Hanson D,Magee L,Murray PG,Saunders E,Abu-Amero SN,Moore GE,Black GC

    更新日期：2012-09-01 00:00:00

  • Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy- and lactation-associated osteoporosis.

    abstract：CONTEXT:Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterized by the occurrence of fragility fractures in the third trimester or early postpartum. OBJECTIVE:To investigate the changes in bone mineral densi...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13557

    authors： Hong N,Kim JE,Lee SJ,Kim SH,Rhee Y

    更新日期：2018-05-01 00:00:00

  • New treatments in type 2 diabetes: a focus on the incretin-based therapies.

    abstract：:The demonstration that the incretin hormone glucagon-like peptide 1 can improve glycaemic control in patients with type 2 diabetes has led to the rapid development during the last decade of promising new classes of agent for the management of type 2 diabetes. These agents possess a range of physiological effects that ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2265.2008.03396.x

    authors： Barnett AH

    更新日期：2009-03-01 00:00:00

  • Maternal hypothyroxinemia and effects on cognitive functioning in childhood: how and why?

    abstract：:Exposure to maternal hypothyroxinemia during pregnancy, which is characterized by low free T4 but normal thyroid-stimulating hormone (TSH) levels, can negatively affect the foetus. This review provides an overview of present findings concerning the association between maternal hypothyroxinemia during pregnancy and chi...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1111/cen.12227

    authors： Henrichs J,Ghassabian A,Peeters RP,Tiemeier H

    更新日期：2013-08-01 00:00:00

  • Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression.

    abstract：OBJECTIVE:Although autoantibody production is a key feature of autoimmunity, it is not known whether variation in autoantibody production and clearance pathways is involved in disease susceptibility. The Fc Gamma Receptor IIa (FcGRIIa) molecule is involved in the clearance of autoantibodies and a functional single nucl...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2010.03780.x

    authors： Yesmin K,Hargreaves C,Newby PR,Brand OJ,Heward JM,Franklyn JA,Gough SC,Simmonds MJ

    更新日期：2010-07-01 00:00:00

  • Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women.

    abstract：OBJECTIVE:Low sex hormone-binding globulin (SHBG) is a consistent risk factor for type 2 diabetes, particularly in women. Coffee consumption has been associated with a lower risk of type 2 diabetes, but its effects on SHBG are less known. DESIGN AND METHODS:This was a cross-sectional study of 2377 nondiabetic pre- and...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13411

    authors： Pihan-Le Bars F,Gusto G,Boutron-Ruault MC,Fagherazzi G,Bonnet F

    更新日期：2017-11-01 00:00:00

  • Effect of oral frusemide on diagnostic indices of thyroid function.

    abstract：:We studied the acute effect of standard therapeutic doses of oral frusemide on indices of thyroid function in 34 hospital in-patients with congestive cardiac failure. A transient decrease in total T4, elevation in the T3 resin uptake and consequent increase in the free T4 index (FT4I) were seen 2-5 h after ingestion o...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1987.tb00799.x

    authors： Newnham HH,Hamblin PS,Long F,Lim CF,Topliss DJ,Stockigt JR

    更新日期：1987-04-01 00:00:00

  • Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormone(s) and antithyroid treatment.

    abstract：:The effects of thyroid hormones and antithyroid treatment upon lumbar spine bone mineral content (lumbar BMC) were studied in a consecutive series of patients with myxoedema and thyrotoxicosis, respectively. All patients were investigated in the untreated state and 3-monthly during appropriate treatment for 1 year by ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1983.tb02873.x

    authors： Krølner B,Jørgensen JV,Nielsen SP

    更新日期：1983-05-01 00:00:00

  • Visceral adipose tissue accumulation and cardiovascular disease risk profile in postmenopausal women with impaired glucose tolerance or type 2 diabetes.

    abstract：OBJECTIVE:Women with impaired glucose tolerance (IGT) and type 2 diabetes (T2D) are more at risk of cardiovascular disease. The aim of this study was to test the hypothesis that increased visceral adipose tissue (VAT) could explain to a large extent alterations in the cardiovascular disease risk profile of postmenopaus...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2010.03933.x

    authors： Lemieux S,Bédard A,Piché MÈ,Weisnagel SJ,Corneau L,Bergeron J

    更新日期：2011-03-01 00:00:00

  • ACTH-secreting pituitary microadenomas are associated with a higher prevalence of central hypothyroidism compared to other microadenoma types.

    abstract：CONTEXT:Unlike pituitary macroadenomas, microadenomas (micros) are not commonly associated with hypopituitarism. In clinical practice, we have observed that patients with ACTH-secreting micros have a higher than expected prevalence of central hypothyroidism (HT), and we speculated that this effect might be because of g...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2012.04442.x

    authors： Mathioudakis N,Thapa S,Wand GS,Salvatori R

    更新日期：2012-12-01 00:00:00

  • Reversibility of endurance training-induced changes on glucocorticoid sensitivity of monocytes by an acute exercise.

    abstract：OBJECTIVE:The aim of this study was to address the effect of endurance training on monocyte glucocorticoid sensitivity in vitro. METHODS:For this purpose, in vitro dexamethasone inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) secretion in cultures of peripheral monocytes was compared in 6 untrained...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1999.00878.x

    authors： Duclos M,Minkhar M,Sarrieau A,Bonnemaison D,Manier G,Mormede P

    更新日期：1999-12-01 00:00:00