Effect of oral frusemide on diagnostic indices of thyroid function.

abstract：OBJECTIVE:Primary hyperparathyroidism (PHPT) is an uncommonly diagnosed condition among adolescents and young adults. We review the clinical characteristics of these patients based on our institutional experience. SUBJECTS:Patients aged 12-28 years treated for PHPT at our institution from 1990 to 1996 were evaluated b...

journal_title：Clinical endocrinology

authors： Loh KC,Duh QY,Shoback D,Gee L,Siperstein A,Clark OH

更新日期：1998-04-01 00:00:00

abstract：:Oestrogens are known to enhance both basal and stimulated GH secretion. To examine whether this effect is mediated through the hypothalamus or the pituitary we performed insulin tolerance and GH-releasing hormone (GHRH) tests with and without oestrogen priming in a group of 14 short children. Pretreatment with stilboe...

journal_title：Clinical endocrinology

authors： Ross RJ,Grossman A,Davies PS,Savage MO,Besser GM

更新日期：1987-08-01 00:00:00

abstract：:A controlled therapeutic trial on seventy-four 70-year-old women was carried out with the purpose of finding the optimal treatment for post menopausal osteoporosis. The bone mineral content (BMC) was measured by I-photonabsorptiometry at two sites in the distal part of the forearms, where the trabecular/cortical ratio...

journal_title：Clinical endocrinology

authors： Jensen GF,Christiansen C,Transbøl I

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population-based setting or in the context of exposure to radioactive iodine-131 (I-131). ...

journal_title：Clinical endocrinology

authors： Cahoon EK,Rozhko A,Hatch M,Polyanskaya O,Ostroumova E,Tang M,Nadirov E,Yauseyenka V,Savasteeva I,McConnell RJ,Pfeiffer RM,Brenner AV

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The differentiation of benign from malignant phaeochromocytoma is difficult. We have examined whether the use of flow cytometric determination of nuclear DNA content would be useful as a predictor of malignant behaviour in patients with phaeochromocytoma as some previous studies had suggested t...

journal_title：Clinical endocrinology

authors： Heaney AP,O'Rourke D,Arthur K,Beatty OL,Russell CF,Sloan JM,Hamilton P,Atkinson AB

更新日期：1996-02-01 00:00:00

abstract：:The opiate control of the pituitary-adrenal axis has been investigated in normal subjects. The infusion of 1 mg of the met-enkephalin analogue, DAMME, led to a fall in circulating cortisol in spite of a fall in blood pressure. Conversley, 16 mg of the opiate antagonist, naloxone led to brisk and pronounced elevations ...

journal_title：Clinical endocrinology

authors： Grossman A,Gaillard RC,McCartney P,Rees LH,Besser GM

更新日期：1982-09-01 00:00:00

abstract：:The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the r...

journal_title：Clinical endocrinology

authors： van der Spuy ZM,Jones DL,Wright CS,Piura B,Paintin DB,James VH,Jacobs HS

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:The risk of progression of subclinical hypothyroidism (SCH) to clinical dysfunction is one of the factors considered in the decision to treat this condition. This study evaluated the natural history of SCH in women with TSH ≤10 mIU/l. DESIGN:This is a prospective study. PATIENTS:Two hundred and fifty-two wo...

journal_title：Clinical endocrinology

authors： Rosário PW,Carvalho M,Calsolari MR

更新日期：2016-06-01 00:00:00

abstract：:Eleven women with secondary amenorrhoea and hyperprolactinaemia were treated with lisuride, a new semisynthetic ergot derivative. Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects. In these nine patients, prolonged treatment wit...

journal_title：Clinical endocrinology

authors： De Cecco L,Foglia G,Ragni N,Rossato P,Venturini PL

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS:To evaluate the extent to which GH replacement might reverse the in...

journal_title：Clinical endocrinology

authors： Karbownik-Lewinska M,Kokoszko A,Lewandowski KC,Shalet SM,Lewinski A

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:We assessed the relative risk of both serum TSH and antithyroid antibody concentrations with regard to progression of thyroid failure and studied the lipid profiles of individuals with elevated TSH levels. DESIGN, PATIENTS AND MEASUREMENTS:In a randomly selected group of 427 women aged 40-60 (mean 55) years ...

journal_title：Clinical endocrinology

authors： Geul KW,van Sluisveld IL,Grobbee DE,Docter R,de Bruyn AM,Hooykaas H,van der Merwe JP,van Hemert AM,Krenning EP,Hennemann G

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Hydrocortisone therapy should be individualized in congenital adrenal hyperplasia (CAH) patients to avoid over and under replacement. We have assessed how differences in absorption and half-life of cortisol influence glucocorticoid exposure. PATIENTS AND METHODS:Forty-eight patients (21 M) aged between 6·1 ...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Charmandari E

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Associations between calcium-sensing receptor (CaSR) polymorphisms and serum calcium, PTH and bone mineral density (BMD) have been reported by six studies. However, three other studies have failed to detect such associations. We therefore further investigated three CaSR coding region polymorphisms (Ala986Ser...

journal_title：Clinical endocrinology

authors： Harding B,Curley AJ,Hannan FM,Christie PT,Bowl MR,Turner JJ,Barber M,Gillham-Nasenya I,Hampson G,Spector TD,Thakker RV

更新日期：2006-11-01 00:00:00

abstract：:Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine system. There has been a significant increase in its incidence over the past two decades attributable mainly to the use of more sensitive diagnostic modalities. Ultrasound-guided fine needle aspiration cytology is the mainstay of diagno...

journal_title：Clinical endocrinology

authors： Nixon AM,Provatopoulou X,Kalogera E,Zografos GN,Gounaris A

更新日期：2017-08-01 00:00:00

abstract：:The glucose and immunoreactive insulin (IRI) responses to a 100 g oral glucose tolerance test (oGTT) administered to 23 acromegalic patients before and after transsphenoidal adenomectomy and to a sex and age-matched control group were studied. The preoperative growth hormone levels, ranging from 11 to 360 mU/l, had no...

journal_title：Clinical endocrinology

authors： Roelfsema F,Frölich M

更新日期：1985-04-01 00:00:00

abstract：CONTEXT:Few studies have evaluated the metabolic outcomes of growth hormone (GH) treatment in idiopathic short stature (ISS). Moreover, children with ISS appear to need higher GH doses than children with GH deficiency (GHD) to achieve the same amount of growth and may therefore be at increased risk of adverse events du...

journal_title：Clinical endocrinology

authors： Decker R,Albertsson-Wikland K,Kriström B,Nierop AF,Gustafsson J,Bosaeus I,Fors H,Hochberg Z,Dahlgren J

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 is an insulin secretion-stimulating gut hormone that is produced in response to food intake. Orlistat (Xenical, F. Hoffman-La Roche, Basel, Switzerland), which decreases fat absorption and increases intestinal fat content, may therefore affect the secretion of glucagon-like peptide-1. ...

journal_title：Clinical endocrinology

authors： Sahin M,Tanaci N,Yucel M,Tutuncu NB,Guvener N

更新日期：2007-09-01 00:00:00

abstract：:Radioiodine has been in use for over 60 years as a treatment for hyperthyroidism. Major changes in clinical practice have occurred with the realization that accurate dosimetry is incapable of avoiding the risks of hypothyroidism, while more accurate assessment of the risks of other adverse effects of radioiodine such ...

journal_title：Clinical endocrinology

authors： Weetman AP

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Adrenal vein sampling (AVS) failure is mainly due to right adrenal vein unavailability. Multinomial regression modelling (MRM) and left adrenal vein-to-peripheral vein ratio (LAV/PV) were proposed to predict the lateralization index without the right AVS. OBJECTIVE:To assess external validity of MRM and LAV...

journal_title：Clinical endocrinology

authors： Bouchard-Bellavance R,Perrault F,Soulez G,Chagnon M,Kline GA,Bourdeau I,Lacroix A,So B,Therasse E

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Results from the published studies on the association of adiponectin gene (ADIPOQ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729), with these traits in ...

journal_title：Clinical endocrinology

authors： Zhao T,Zhao J

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study...

journal_title：Clinical endocrinology

authors： Wu X,Zhu X,Wang X,Ma J,Zhu S,Li J,Liu Y

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:A number of surgical series have been reported on the treatment of acromegaly and their results vary widely. The acceptable definition of remission has changed in recent years and it is known, though in a small series, that growth hormone levels of > 5 mU/l are still associated with an increased mortality fr...

journal_title：Clinical endocrinology

authors： Ahmed S,Elsheikh M,Stratton IM,Page RC,Adams CB,Wass JA

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:PTH(1-84) secretion in normal male subjects follows a circadian rhythm. The control of this rhythm is multifactorial with both neuroendocrine and chemical influences. The aim of this study was to assess the effect of a 96-hour fast on the circadian rhythm of PTH(1-84), serum calcium, phosphate and nephrogenou...

journal_title：Clinical endocrinology

authors： Fraser WD,Logue FC,Christie JP,Cameron DA,O'Reilly DS,Beastall GH

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (...

journal_title：Clinical endocrinology

authors： Bosch E,Nyboe Andersen A,Barri P,García-Velasco JA,de Sutter P,Fernández-Sánchez M,Visnova H,Klein BM,Mannaerts B,Arce JC

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort® , an immediate-release, granule formulation of hydroco...

journal_title：Clinical endocrinology

authors： Neumann U,Whitaker MJ,Wiegand S,Krude H,Porter J,Davies M,Digweed D,Voet B,Ross RJ,Blankenstein O

更新日期：2018-01-01 00:00:00

abstract：:Serum concentrations of total and free T4 (TT4 and FT4), total and free T3 (TT3 and FT3), rT3, T4 binding globulin (TBG), T3 uptake (T3U) and TSH were measured in 12 patients with severe hypothyroidism before and during the introduction of replacement therapy with oral T4. The dose of T4 was increased by increments of...

journal_title：Clinical endocrinology

authors： Pearce CJ,Himsworth RL

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Acromegalic patients have increased prevalence of colonic polyps. Development of hyperplastic polyps was related to suppressor of cytokine signalling (SOCS) 2 haploinsufficiency in animal models of acromegaly. OBJECTIVE AND PATIENTS:To evaluate whether variations in SOCS2 expression in the colonic mucosa of...

journal_title：Clinical endocrinology

authors： Bogazzi F,Ultimieri F,Raggi F,Russo D,Costa A,Marciano E,Bartalena L,Martino E

更新日期：2009-06-01 00:00:00

abstract：CONTEXT:Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive weight-adapted standard glucocorticoid replacement therapy. Clinically, some patients appear more sensitive to therapeutic administration of glucocorticoids than others. Glucocorticoid sensitivity is...

journal_title：Clinical endocrinology

authors： Koetz KR,van Rossum EF,Ventz M,Diederich S,Quinkler M

更新日期：2013-06-01 00:00:00

abstract：:We studied the circadian rhythm and the response of the hypothalamic-pituitary-adrenal (HPA) axis to ovine corticotrophin releasing hormone (oCRH) stimulation and dexamethasone suppression in 32 children with grade II-III marasmus. Children were studied prior to and after nutritional rehabilitation. Mean baseline plas...

journal_title：Clinical endocrinology

authors： Malozowski S,Muzzo S,Burrows R,Leiva L,Loriaux L,Chrousos G,Winterer J,Cassorla F

更新日期：1990-04-01 00:00:00

abstract：:Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months. In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibi...

journal_title：Clinical endocrinology

authors： Kauli R,Pertzelan A,Ben-Zeev Z,Lewin RP,Kaufman H,Schally AM,Schally AV,Laron Z

更新日期：1984-04-01 00:00:00