Treatment of precocious puberty with LHRH analogue in combination with cyproterone acetate-further experience.

abstract：OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

journal_title：Clinical endocrinology

authors： Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:The incidence of thyroid cancer is increasing in several countries. The aim was to investigate trends in the incidence and mortality of thyroid cancer in Scotland, where thyroid cancer is relatively uncommon, between 1960 and 2002. DESIGN:Descriptive epidemiological study. METHODS:Thyroid cancer registratio...

journal_title：Clinical endocrinology

authors： Reynolds RM,Weir J,Stockton DL,Brewster DH,Sandeep TC,Strachan MW

更新日期：2005-02-01 00:00:00

abstract：:We report the case of a male infant who at 10 days of life presented with salt-wasting. Congenital adrenal hyperplasia was excluded on the basis of normal 17 alpha-hydroxy-progesterone plasma levels evaluated before the onset of steroid replacement therapy. The incidental finding of hypertriglyceridaemia led us to sus...

journal_title：Clinical endocrinology

authors： Balducci R,Municchi G,Toscano V,Mangiantini A,Sabatini R,Caiola S,Tedeschi B,Orlandi L,Boscherini B

更新日期：1995-04-01 00:00:00

abstract：:The initial presentation of macroprolactinoma with visual field impairment, especially in males, is well recognized. Successful treatment with dopamine agonist therapy is characterized by a reduction in hyperprolactinaemia and often rapid and progressive resolution of the visual impairment. A small proportion of patie...

journal_title：Clinical endocrinology

authors： Jones SE,James RA,Hall K,Kendall-Taylor P

更新日期：2000-10-01 00:00:00

abstract：:Plasma glucagon response to an arginine infusion was studied in children and adolescents belonging to the following groups: (I) twenty-two controls; (II) six subjects with delayed insulin peak during oral GTT; (III) ten diabetics on diet and/or oral therapy; (IV) six newly diagnosed uncompensated diabetics; and (V) ei...

journal_title：Clinical endocrinology

authors： Josefsberg Z,Laron Z,Doron M,Keret R,Belinski Y,Weismann I

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate symptoms of thyrotoxicosis, bone turnover, bone mineral density (BMD) and occult atrial fibrillation (AF) in women ≥65 years with mild endogenous subclinical hyperthyroidism (SCH). DESIGN:Cross-sectional and case-control study. PATIENTS:Signs and symptoms of thyro...

journal_title：Clinical endocrinology

authors： Rosario PW,Carvalho M,Calsolari MR

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To evaluate whether thyroid scintigraphy would alter the clinical management of patients referred for fine-needle aspiration cytology (FNA). METHODS:We reviewed the medical and imaging records of patients referred to our Department between 2016 and 2019. All the patients had to take a serum thyrotropin test ad...

journal_title：Clinical endocrinology

authors： Pirola I,Di Lodovico E,Casella C,Pezzaioli L,Facondo P,Ferlin A,Lombardi D,Cappelli C

更新日期：2020-12-17 00:00:00

abstract：:Twenty-one patients with hyperthyroid Graves' disease were treated with carbimazole 30 mg daily, given as a single dose. Propranolol was also given for the first 3 weeks. All became clinically euthyroid with normal serum thyroxine (T4) levels, usually within 1-3 months. Patients with large goitres and raised serum alk...

journal_title：Clinical endocrinology

authors： MacFarlane IA,Davies D,Longson D,Shalet SM,Beardwell CG

更新日期：1983-06-01 00:00:00

abstract：:It has been suggested that abnormalities of thirst and vasopressin secretion commonly coexist with Kallmann's syndrome. Out-patient plasma osmolality, plasma sodium and 24-hour urine volume were similar in 10 patients with Kallmann's syndrome and 10 matched controls. Six patients underwent dynamic testing of osmoregul...

journal_title：Clinical endocrinology

authors： Thompson CJ,White MC,Baylis PH

更新日期：1989-05-01 00:00:00

abstract：:The HLA-A and -B antigen distribution in 132 Hong Kong Chinese patients with Graves' disease, including 24 with thyrotoxic periodic paralysis, was compared with that in 110 controls. The HLA-DR antigen distribution in 68 patients was compared with that in 47 controls. The prevalence of Bw46 was significantly increased...

journal_title：Clinical endocrinology

authors： Hawkins BR,Ma JT,Lam KS,Wang CC,Yeung RT

更新日期：1985-09-01 00:00:00

abstract：:Twenty-four hyperprolactinaemic women were treated for 6 months with the new, non-ergot, long-acting dopamine agonist, CV 205-502. The treatment resulted in normalization of PRL secretion in 17 of the 24 women at once-daily doses of 0.05 to 0.15 mg of the drug. Sixteen of these women as well as 4 of those who remained...

journal_title：Clinical endocrinology

authors： Rasmussen C,Bergh T,Wide L,Brownell J

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:To provide evidence of efficacy and safety for use of lutropin alfa in inducing follicular development and pregnancy in hypogonadotrophic hypogonadal women with profound gonadotrophin deficiency. DESIGN:An open-label, noncomparative extension of a randomized, double-blind, placebo-controlled study PATIENTS:...

journal_title：Clinical endocrinology

authors： Kaufmann R,Dunn R,Vaughn T,Hughes G,O'Brien F,Hemsey G,Thomson B,O'Dea LS

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

journal_title：Clinical endocrinology

authors： Coussa A,Hasan HA,Barber TM

更新日期：2020-12-01 00:00:00

abstract：:The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion. Blood sugar nadir occurred at the onset of symptoms (t...

journal_title：Clinical endocrinology

authors： Nussey SS,Page SR,Ang VT,Jenkins JS,White A

更新日期：1988-09-01 00:00:00

abstract：:Pituitary homogenates were prepared from patients undergoing pituitary ablation for breast or prostatic carcinoma (controls) and from patients with either PRL- and GH-secreting pituitary adenomas or from patients with 'functionless' pituitary tumours. The principal subcellular organelles, plasma membrane, lysosomes, m...

journal_title：Clinical endocrinology

authors： De Marco L,Mashiter K,Peters TJ

更新日期：1984-11-01 00:00:00

abstract：:This study deals with serum prolactin concentrations during various conditions in the early puerperium in an attempt to investigate some characteristics of the mechanisms responsible for the regulation of the lactotropes. In nursing, in non-nursing, non-medicated and in non-nursing, bromocriptine-treated women prolact...

journal_title：Clinical endocrinology

authors： Vemer HM,Rolland R

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Classical congenital adrenal hyperplasia (CAH) is characterized by a defect in cortisol and aldosterone secretion, adrenal hyperandrogenism, impaired adrenal medullary function and insulin insensitivity. The latter along with the increased tendency towards obesity raises questions whether other cardiovascula...

journal_title：Clinical endocrinology

authors： Roche EF,Charmandari E,Dattani MT,Hindmarsh PC

更新日期：2003-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Individuals with impaired fasting glucose (IFG) are at increased risk of developing diabetes over the subsequent decade. However, there is uncertainty as to the mechanisms contributing to the development of diabetes. We sought to quantitate insulin secretion and action across the prediabetic range of fa...

journal_title：Clinical endocrinology

authors： Sathananthan A,Dalla Man C,Zinsmeister AR,Camilleri M,Rodeheffer RJ,Toffolo G,Cobelli C,Rizza RA,Vella A

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Whether subclinical hypothyroidism adversely impacts pregnancy outcomes is inconclusive, and limited data are available on the optimal TSH range in women planning pregnancy. OBJECTIVE:To investigate the association between maternal preconception TSH levels and pregnancy outcomes. DESIGN:Population-based co...

journal_title：Clinical endocrinology

authors： Chen S,Zhou X,Zhu H,Yang H,Gong F,Wang L,Zhang M,Jiang Y,Yan C,Li J,Wang Q,Zhang S,Pan H

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Confirmation of monogenic diabetes caused by glucokinase mutations (GCK-MODY) allows pharmacogenetic intervention in the form of insulin discontinuation. This is especially important among paediatric and young adult populations where GCK-MODY is most prevalent. METHODS:The study evaluated the utility of l...

journal_title：Clinical endocrinology

authors： Fendler W,Borowiec M,Antosik K,Szadkowska A,Deja G,Jarosz-Chobot P,Mysliwiec M,Wyka K,Pietrzak I,Skupien J,Malecki MT,Mlynarski W

更新日期：2011-09-01 00:00:00

abstract：CONTEXT:Primary hyperparathyroidism is a common condition and results in hypercalcaemia, especially in older women. Thus, it is critical to obtain a robust estimate for the upper limit of the reference interval for albumin-adjusted serum calcium in the general population. The current reference interval in use in the UK...

journal_title：Clinical endocrinology

authors： Schini M,Hannan FM,Walsh JS,Eastell R

更新日期：2021-01-01 00:00:00

abstract：:The uterine cross-sectional area (UXA) of women with polycystic (PCO) or multifollicular ovaries (MFO) is significantly larger and smaller, respectively, than those of normal women during the early-mid-follicular phase of the menstrual cycle. In the present study the distribution of oestradiol in plasma from normal wo...

journal_title：Clinical endocrinology

authors： Polson DW,Franks S,Reed MJ,Cheng RW,Adams J,James VH

更新日期：1987-05-01 00:00:00

abstract：CONTEXT:Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive weight-adapted standard glucocorticoid replacement therapy. Clinically, some patients appear more sensitive to therapeutic administration of glucocorticoids than others. Glucocorticoid sensitivity is...

journal_title：Clinical endocrinology

authors： Koetz KR,van Rossum EF,Ventz M,Diederich S,Quinkler M

更新日期：2013-06-01 00:00:00

abstract：:The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We su...

journal_title：Clinical endocrinology

authors： Geurts J,Demeester-Mirkine N,Glinoer D,Prigogine T,Fernandez-Deville M,Corvilain J

更新日期：1981-02-01 00:00:00

abstract：:The effect of oral glucose (40 g/m2 body surface area) on the leucocyte 22Na efflux rate constants (ERC) was studied in 13 normal weight and 10 obese subjects. The ouabain-sensitive 22Na ERC was higher in leucocytes isolated from fasting obese subjects (median [range] for obese 2.77 [2.33-3.11] vs normals 1.91 [1.57-2...

journal_title：Clinical endocrinology

authors： Ng LL,Hockaday TD

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVE:To assess current provision of specialist and transitional paediatric endocrine services in the UK and Ireland. DESIGN:A questionnaire was sent to paediatric endocrinologists requesting details of patients receiving GH and also details of specialist and transitional services. RESULTS:Of 72 questionnaires re...

journal_title：Clinical endocrinology

authors： Kirk J,Clayton P

更新日期：2006-07-01 00:00:00

abstract：:A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was r...

journal_title：Clinical endocrinology

authors： Katsuren E,Ishikawa S,Honda K,Saito T

更新日期：1997-05-01 00:00:00

abstract：:In recent years the techniques of molecular and cellular biology have made it possible to begin to dissect the origins and behaviour of the ACTH-secreting tumour cell. It is becoming apparent that these tumours represent undifferentiated neuroendocrine cells, and it may be that their peptide-secreting properties may h...

journal_title：Clinical endocrinology

authors： White A,Clark AJ

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. DESIGN:The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents wi...

journal_title：Clinical endocrinology

authors： Interdonato M,Pizzino G,Bitto A,Galfo F,Irrera N,Mecchio A,Pallio G,Ramistella V,De Luca F,Santamaria A,Minutoli L,Marini H,Squadrito F,Altavilla D

更新日期：2015-09-01 00:00:00

abstract：:Diagnosis of XY pure gonadal dysgenesis was established in a patient of female phenotype, with female internal genitalia, but with a chromosomal constitution of 46 XY. Streak gonads had undergone neoplastic transformation--gonadoblastoma and dysgerminoma. Before operation the concentrations of gonadotrophins in plasma...

journal_title：Clinical endocrinology

authors： Wilson SC,Oakey RE,Scott JS

更新日期：1988-11-01 00:00:00