The cellular and molecular basis of the ectopic ACTH syndrome.

abstract：:Measurements of circulating thyroglobulin (hTg) and 131I whole body scan were performed in 101 patients with differentiated thyroid carcinoma who had been subjected to surgical thyroidectomy and 131I ablation of remaining thyroid tissue. All 45 patients with positive scans (i.e. functioning metastases) had elevated hT...

journal_title：Clinical endocrinology

authors： Pacini F,Pinchera A,Giani C,Grasso L,Baschieri L

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVE:GH deficiency, either in children or in adults, is a clinically relevant problem. The diagnosis is based on dynamic tests of GH secretion, which are clear cut on a group basis but highly problematic for individual diagnosis. The controversy surrounding the diagnosis of GH deficiency reflects the absence of a ...

journal_title：Clinical endocrinology

authors： Micic D,Popovic V,Kendereski A,Peino R,Dieguez C,Casanueva FF

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVES:Patients with type 1 diabetes are at increased risk of cardiovascular disease, which may be related to abnormal lipid metabolism. Secretion and clearance of VLDL apolipoprotein B100 (apoB) are important determinants of plasma lipid concentrations and are known to be influenced by hormones, including insulin ...

journal_title：Clinical endocrinology

authors： Christ ER,Carroll PV,Albany E,Umpleby AM,Lumb PJ,Wierzbicki AS,Simpson HL,Sönksen PH,Russell-Ones DL

更新日期：2001-12-01 00:00:00

abstract：:In-vitro data of pituitary adenoma cells from 28 acromegalic patients were evaluated. In addition to GH, PRL was produced by 16 adenomas (57%) and alpha-subunit by 15 adenomas (54%) while there was a significantly higher incidence of tumours producing PRL and alpha-subunit simultaneously. From 26 pituitary adenomas en...

journal_title：Clinical endocrinology

authors： Hofland LJ,van Koetsveld PM,Verleun TM,Lamberts SW

更新日期：1989-06-01 00:00:00

abstract：:We have examined the characteristics of circulating immunoreactive human calcitonin (IR-hCT) by studying its different molecular weight (MW) forms under various secretory conditions in a patient with medullary carcinoma of the thyroid. Plasma IR-hCT (318 mg/l basal) increased 9 and 12 times, respectively, after calciu...

journal_title：Clinical endocrinology

authors： Bertagna XY,Bloomgarden ZT,Rabin D,Roberts LJ,Orth DN

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Acromegalic patients have increased left ventricular (LV) mass (M) and impaired diastolic function. AIM:Using ultrasonic cardiac tissue characterization, we evaluated the early changes in cardiac fibrosis (IBS) and intrinsic myocardial contractility (CVI) as well as their reversibility after treatment with ...

journal_title：Clinical endocrinology

authors： Bogazzi F,Di Bello V,Palagi C,Donne MG,Di Cori A,Gavioli S,Talini E,Cosci C,Sardella C,Brogioni S,Mariani M,Martino E

更新日期：2005-05-01 00:00:00

abstract：:In the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood-brain barrier. A clearcut elevation in prolactin was produced by domperidone. GH respons...

journal_title：Clinical endocrinology

authors： Brown GM,Verhaegan H,Van Wimersma Greidanus TB,Brugmans J

更新日期：1981-09-01 00:00:00

abstract：OBJECTIVE:Gitelman's syndrome, recognized as a variant of Bartter's syndrome, is characterized by hypokalaemic metabolic alkalosis in combination with hypomagnesaemia and hypocalciuria. Overlapping biochemical features in Gitelman's syndrome and Bartter's syndrome has been observed. Here, we investigated the clinical, ...

journal_title：Clinical endocrinology

authors： Nakamura A,Shimizu C,Nagai S,Yoshida M,Aoki K,Kondo T,Miyoshi H,Wada N,Tajima T,Terauchi Y,Yoshioka N,Koike T

更新日期：2010-02-01 00:00:00

abstract：:Clinical observations and serial determinations of serum thyroglobulin (Tg) were made in five patients with acute haemorrhage into the thyroid gland. Fever, local pain and acceleration of erythrocyte sedimentation rate were minimal or were not observed, and serum T4 and T3 were normal. Although all patients showed an ...

journal_title：Clinical endocrinology

authors： Kawamura S,Kishino B,Tajima K,Mashita K,Tarui S

更新日期：1984-02-01 00:00:00

abstract：:Although there is a circadian rhythm in blood melatonin concentrations in humans, the problems associated with frequent blood collection limit the use of this rhythm in the investigation of the circadian system and in the diagnosis and treatment of chronobiological disorders. Therefore, to establish a convenient, non-...

journal_title：Clinical endocrinology

authors： Nowak R,McMillen IC,Redman J,Short RV

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:Results from studies on the effect of glucocorticosteroids on protein turnover in both rat and man have been conflicting. The aim of this study was to investigate the primary cause of muscle wasting in patients with Cushing's syndrome. DESIGN:Studies of whole body 1(-14)C-leucine turnover in patients with Cu...

journal_title：Clinical endocrinology

authors： Bowes SB,Benn JJ,Scobie IN,Umpleby AM,Lowy C,Sönksen PH

更新日期：1993-11-01 00:00:00

abstract：:Plasma cortisol and adrenocorticotrophin hormone (ACTH) profiles were estimated in twelve patients with Addison's disease following randomized oral administration of either cortisone acetate (25 mg) or hydrocortisone (20 mg) alternately, at 0900 h on consecutive days. Normal corticosteroid replacement therapy was disc...

journal_title：Clinical endocrinology

authors： Feek CM,Ratcliffe JG,Seth J,Gray CE,Toft AD,Irvine WJ

更新日期：1981-05-01 00:00:00

abstract：:High gastrin levels were found in twenty-one out of fifty-six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sp...

journal_title：Clinical endocrinology

authors： Dahlberg PA,Karlsson FA,Lundqvist G

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:The thyroid suppression test is still used in some centres as an adjunt in the diagnosis of autonomous functioning thyroid nodules. With the purpose of minimizing the disadvantages of the original T3 suppression test, we have evaluated the efficacy of a method using L-thyroxine as TSH suppression agent and [9...

journal_title：Clinical endocrinology

authors： Ramos CD,Zantut-Wittmann DE,Tambascia MA,Assumpção L,Etchebehere EC,Camargo EE

更新日期：2000-04-01 00:00:00

abstract：:Prospective observational studies uniformly link vitamin D deficiency with the incidence of type 2 diabetes mellitus (T2DM), yet trials supplementing participants at risk of T2DM with vitamin D to reduce progression to T2DM have yielded inconsistent results. Inconsistencies between supplementation trials may be due to...

journal_title：Clinical endocrinology

authors： Shore-Lorenti C,Brennan SL,Sanders KM,Neale RE,Lucas RM,Ebeling PR

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10 years after the first description of this kindred, has provided an important set of clinical data for healthcare decision-making. DESIGN AND PATIENTS:We identified 728 RET533 Brazilian relatives, spread out over 7 generati...

journal_title：Clinical endocrinology

authors： Signorini PS,França MI,Camacho CP,Lindsey SC,Valente FO,Kasamatsu TS,Machado AL,Salim CP,Delcelo R,Hoff AO,Cerutti JM,Dias-da-Silva MR,Maciel RM

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the volumetric bone mineral density (BMD) in girls with Turner's syndrome (TS) before and during growth hormone (GH) treatment in combination with low dose oestrogens as well as three years after discontinuation of GH treatment. DESIGN:In a prospective, randomized injectio...

journal_title：Clinical endocrinology

authors： Sass TC,De Muinck Keizer-Schrama SM,Stijnen T,Asarfi A,Van Leeuwen WJ,Van Teunenbroek A,Van Rijn RR,Drop SL

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:High overnight plasma growth hormone (GH) levels in insulin-dependent diabetes mellitus (IDDM) are reflected in both an increase in the GH pulse amplitude and elevated baseline GH concentrations. To determine whether these are a result of an increase in GH secretory episodes, we undertook deconvolution analys...

journal_title：Clinical endocrinology

authors： Pal BR,Matthews DR,Edge JA,Mullis PE,Hindmarsh PC,Dunger DB

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Urine calcium after an overnight fast is higher in osteoporotic than in normal post-menopausal women. The question is whether this is the cause or effect of the bone-losing state. OBJECTIVE:To establish whether the elevated obligatory calcium loss in osteoporotic women is due to a raised filtered load of ca...

journal_title：Clinical endocrinology

authors： Nordin BE,Horowitz M,Need A,Morris HA

更新日期：1994-07-01 00:00:00

abstract：:Familial neurohypophysial diabetes insipidus (FNDI) is a rare autosomal dominant syndrome stemming from the absence of arginine vasopressin (AVP). More than thirty-five different germline mutations in the arginine vasopressin-neurophysin II gene have been reported. These mutations are either in the signal peptide or s...

journal_title：Clinical endocrinology

authors： Boson WL,Sarubi JC,d'Alva CB,Friedman E,Faria D,De Marco L,Wajchenberg B

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Polymorphisms in the thyroid transcription factor forkhead factor E1 (FOXE1) gene have been implicated in the genetic susceptibility to differentiated thyroid cancer, but little is known about their effect on tumour characteristics. The objective of this study was to determine the contribution of the FOXE1 po...

journal_title：Clinical endocrinology

authors： Raimundo J,Alvelos MI,Azevedo T,Martins T,Rodrigues FJ,Lemos MC

更新日期：2017-02-01 00:00:00

abstract：CONTEXT:In men, obesity and the metabolic syndrome are accompanied by decreased testosterone levels, but little is known about the associations between visceral adipose tissue (VAT), VAT-related inflammation and sex steroids. OBJECTIVE:To examine the relative impact of VAT, abdominal subcutaneous adipose tissue (SAT) ...

journal_title：Clinical endocrinology

authors： Gautier A,Bonnet F,Dubois S,Massart C,Grosheny C,Bachelot A,Aubé C,Balkau B,Ducluzeau PH

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Papillary thyroid cancer (PTC) is a common endocrine cancer and commonly presents with lymph node (LN) metastases. The role of surgical removal of the central cervical LN compartment is poorly defined. There are no prospective randomized controlled trials addressing the relevance to the extent of the initial...

journal_title：Clinical endocrinology

authors： Mulla M,Schulte KM

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:This study was conducted to determine the effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress among women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS:This randomized, double-blind, placebo-controlled clinical trial was conducted among 69 w...

journal_title：Clinical endocrinology

authors： Bahmani F,Karamali M,Shakeri H,Asemi Z

更新日期：2014-10-01 00:00:00

abstract：:Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months. In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibi...

journal_title：Clinical endocrinology

authors： Kauli R,Pertzelan A,Ben-Zeev Z,Lewin RP,Kaufman H,Schally AM,Schally AV,Laron Z

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:To document current practices in the approach to low testosterone in older men. Given that recommendations are based on low-level evidence, we hypothesized that there would be a wide variability in clinical practice patterns. DESIGN:Members of all major endocrine and andrological societies were invited to pa...

journal_title：Clinical endocrinology

authors： Grossmann M,Anawalt BD,Wu FC

更新日期：2015-02-01 00:00:00

abstract：:The ratios of reverse triiodothyronine (rT3) to triiodothyronine (T3) concentrations were similar (0.89 +/- 0.09) in twenty-three autonomous thyroid nodules (fourteen decompensated, nine compensated) and paranodular tissues (0.82 +/- 0.08), whereas the serum ratio was significantly lower (0.098 +/- 0.014). This is com...

journal_title：Clinical endocrinology

authors： Reinwein D,Durrer H,Emrich D,Meinhold H,Wenzel KW

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Distinguishing malignant thyroid nodules in patients with follicular cytology by fine-needle aspiration (FNA) remains problematic. The large majority of thyroid nodules (> 85%) are overtreated. Therefore, a clear need exists to develop more accurate initial diagnostic tests for follicular thyroid nodules. Ga...

journal_title：Clinical endocrinology

authors： Hooft L,van der Veldt AA,Hoekstra OS,Boers M,Molthoff CF,van Diest PJ

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically avail...

journal_title：Clinical endocrinology

authors： Bereket A,Lang CH,Blethen SL,Ng LC,Wilson TA

更新日期：1996-09-01 00:00:00

abstract：:Post-prandial plasma gastrointestinal hormone profiles were measured in nine chronic alcoholics, one and fourteen days after complete alcohol withdrawal. Basal plasma pancreatic polypeptide concentration (PP--mean +/- SE mean) was significantly greater in alcoholics (control, 28 +/- 5 pmol/l; alcoholics, post-withdraw...

journal_title：Clinical endocrinology

authors： Fink RS,Adrian TE,Margot DH,Bloom SR

更新日期：1983-04-01 00:00:00