The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial.


OBJECTIVE:This study was conducted to determine the effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress among women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS:This randomized, double-blind, placebo-controlled clinical trial was conducted among 69 women diagnosed with PCOS and aged 18-40 year old. Participants were randomly assigned to three groups receiving the following: (1) folate-1: 1 mg/d folate supplements (N = 23); (2) folate-5: 5 mg/d folate supplements (N = 23) and (3) placebo (N = 23) for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8 weeks to measure homocysteine (Hcy), inflammatory factors including high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), biomarkers of oxidative stress including total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA) and homoeostatic model assessment-beta cell function (HOMA-B). RESULTS:Supplementation with 5 mg/d folate resulted in reduced plasma Hcy (-2·23 vs -1·86 and 1·16 μm, respectively, P < 0·05), HOMA-B (-7·63 vs 1·43 and 13·66, respectively, P < 0·05), serum hs-CRP (-212·2 vs -262·4 and 729·8 μg/l, respectively, P < 0·05) and plasma MDA concentrations (-0·48 vs -0·24 and 0·69 μm, respectively, P < 0·01) compared with folate-1 and placebo groups. Furthermore, a significant rise in plasma TAC (0·64 vs -3·53 and -215·47 mm, respectively, P < 0·01) and GSH levels (162·1 vs 195·8 and -158·2 μm, respectively, P < 0·01) was also observed following the administration of 5 mg/d folate supplements compared with folate-1 and placebo groups. CONCLUSIONS:In conclusion, folate supplementation (5 mg/d) in women with PCOS had beneficial effects on inflammatory factors and biomarkers of oxidative stress.


Clin Endocrinol (Oxf)


Clinical endocrinology


Bahmani F,Karamali M,Shakeri H,Asemi Z




Has Abstract


2014-10-01 00:00:00












  • The effect of oral glucose on the leucocyte sodium pump in normal and obese subjects.

    abstract::The effect of oral glucose (40 g/m2 body surface area) on the leucocyte 22Na efflux rate constants (ERC) was studied in 13 normal weight and 10 obese subjects. The ouabain-sensitive 22Na ERC was higher in leucocytes isolated from fasting obese subjects (median [range] for obese 2.77 [2.33-3.11] vs normals 1.91 [1.57-2...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ng LL,Hockaday TD

    更新日期:1987-09-01 00:00:00

  • Associations between metabolomic-identified changes of biomarkers and arterial stiffness in subjects progressing to impaired fasting glucose.

    abstract:OBJECTIVE:We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG). DESIGN, SUBJECTS, MEASUREMENT:This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medic...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Jung S,Kim M,Lee YJ,Lee SH,Lee JH

    更新日期:2015-08-01 00:00:00

  • Effects of in vitro fertilization (IVF) therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

    abstract:RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Coussa A,Hasan HA,Barber TM

    更新日期:2020-12-01 00:00:00

  • The continuous 7-hour intravenous dexamethasone suppression test in the differential diagnosis of ACTH-dependent Cushing's syndrome.

    abstract:OBJECTIVE:A recent report showing disappointingly low sensitivity and specificity for the oral high dose dexamethasone test in the differential diagnosis of Cushing's syndrome prompted us to re-evaluate the results obtained in our centre using the continuous 7-hour intravenous dexamethasone suppression test for this pu...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: van den Bogaert DP,de Herder WW,de Jong FH,Biemond P,van der Lely AJ,Lamberts SW

    更新日期:1999-08-01 00:00:00

  • The majority of Danish nontoxic goitre patients are ineligible for Levothyroxine suppressive therapy.

    abstract:OBJECTIVE:Levothyroxine suppressive therapy (LT4-therapy), aimed at shrinking thyroid nodules is controversial. Despite evidence of limited effect and long-term side-effects, questionnaire surveys indicate widespread use. Our aim was to determine, in consecutive nontoxic goitre patients, the proportion ineligible for L...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Fast S,Bonnema SJ,Hegedüs L

    更新日期:2008-10-01 00:00:00

  • Chemerin and prediction of Diabetes mellitus type 2.

    abstract:OBJECTIVE:Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM. DESIGN:Blood samples of 440 participants of the Metabol...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bobbert T,Schwarz F,Fischer-Rosinsky A,Maurer L,Möhlig M,Pfeiffer AF,Mai K,Spranger J

    更新日期:2015-06-01 00:00:00

  • Cognitive impairment is prevalent in pseudohypoparathyroidism type Ia, but not in pseudopseudohypoparathyroidism: possible cerebral imprinting of Gsalpha.

    abstract:OBJECTIVE:Pseudohypoparathyroidism type Ia (PHP-Ia) is a hereditary disorder characterized by resistance to multiple hormones that work via cAMP such as PTH and TSH, accompanied by typical skeletal features including short stature and brachydactyly, termed Albright hereditary osteodystrophy (AHO). In affected kindreds,...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mouallem M,Shaharabany M,Weintrob N,Shalitin S,Nagelberg N,Shapira H,Zadik Z,Farfel Z

    更新日期:2008-02-01 00:00:00

  • Association between androgens, intima-media thickness and the metabolic syndrome in obese adolescent girls.

    abstract:BACKGROUND:While an association between androgens and the metabolic syndrome (MS) is well established in obese women, studies concerning this relationship are scarce in obese adolescent girls. Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group. METHODS:In ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: de Sousa G,Brodoswki C,Kleber M,Wunsch R,Reinehr T

    更新日期:2010-06-01 00:00:00

  • Suppression of parathyroid hormone inhibitory activity of plasma in pseudohypoparathyroidism type I by i.v. calcium.

    abstract::The biological response, as measured in the cytochemical bioassay, to the high circulating levels of immunoreactive parathyroid hormone (iPTH) in patients with pseudohypoparathyroidism type I (PSPI) is affected by the presence of an endogenous inhibitor. This is evidenced by the reduced recovery of the biological acti...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Loveridge N,Fischer JA,Devogelaer JP,Nagant de Deuxchaisnes C

    更新日期:1986-05-01 00:00:00

  • Changes in the expression of suppressor of cytokine signalling (SOCS) 2 in the colonic mucosa of acromegalic patients are associated with hyperplastic polyps.

    abstract:BACKGROUND:Acromegalic patients have increased prevalence of colonic polyps. Development of hyperplastic polyps was related to suppressor of cytokine signalling (SOCS) 2 haploinsufficiency in animal models of acromegaly. OBJECTIVE AND PATIENTS:To evaluate whether variations in SOCS2 expression in the colonic mucosa of...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bogazzi F,Ultimieri F,Raggi F,Russo D,Costa A,Marciano E,Bartalena L,Martino E

    更新日期:2009-06-01 00:00:00

  • Different states of clinical control are associated with changes in IGF-I and IGFBPs in children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract:OBJECTIVE:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is characterized by high androgen levels, ambiguous genitalia or premature pubarche, increased height velocity and skeletal maturation. Considering the possibility of changes in the IGF system components depending on the state of c...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cunha HM,Elias LL,Camacho-Hübner C,Moreira AC,Martinelli CE Jr

    更新日期:2004-07-01 00:00:00

  • Effect of an OT antagonist on the control of the midcycle LH surge in women.

    abstract:OBJECTIVE:Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge. DESIGN:Normal women were studied over two cycles. Whe...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vanakara P,Dafopoulos K,Papastergiopoulou L,Kallitsaris A,Papageorgiou I,Messinis IE

    更新日期:2009-07-01 00:00:00

  • IGF-I in a normal population: relation to psychosocial factors.

    abstract:OBJECTIVE:IGF-I has important actions on cell division, apoptosis, differentiation and metabolism, as well as on cell proliferation in vascular smooth muscle. Deficiency of GH, an important regulator of IGF-I, is associated with reduced well-being. IGF-I levels have been related to cognitive function in older individua...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Unden AL,Elofsson S,Knox S,Lewitt MS,Brismar K

    更新日期:2002-12-01 00:00:00

  • Pheochromocytomas are diagnosed incidentally and at older age in neurofibromatosis type 1.

    abstract:INTRODUCTION:Guidelines do not currently recommend routine systematic hormonal screening for pheochromocytoma (PHEO) in all/normotensive patients with neurofibromatosis type 1 (NF1), in contrast to other PHEO-predisposing genetic syndromes such as Von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. OBJ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Moramarco J,El Ghorayeb N,Dumas N,Nolet S,Boulanger L,Burnichon N,Lacroix A,Elhaffaf Z,Gimenez Roqueplo AP,Hamet P,Bourdeau I

    更新日期:2017-03-01 00:00:00

  • Quinagolide efficacy and tolerability in hyperprolactinaemic patients who are resistant to or intolerant of bromocriptine.

    abstract:OBJECTIVE:To audit the efficacy of quinagolide (CV205-502, Norprolac, Sandoz) in lowering prolactin, and its tolerability, in patients with bromocriptine resistance (BCR) or bromocriptine intolerance (BCI), in view of the paucity of results published in patients specifically with BCR or BCI, by collating results in our...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Vilar L,Burke CW

    更新日期:1994-12-01 00:00:00

  • Clinical and genetic changes in a case of a Cushing's carcinoma.

    abstract::A 30-year-old presented in 1984 with a clinically nonfunctional tumour which subsequently developed into a metastatic corticotrophinoma from which he died despite surgery in 1984, 1986 and 1991 and external radiotherapy in 1986. Molecular genetic analysis of tumour and metastatic tissue revealed loss of heterozygosity...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bates AS,Buckley N,Boggild MD,Bicknell EJ,Perrett CW,Broome JC,Clayton RN

    更新日期:1995-06-01 00:00:00

  • HDL cholesterol as a diagnostic tool for clinical differentiation of GCK-MODY from HNF1A-MODY and type 1 diabetes in children and young adults.

    abstract:INTRODUCTION:Confirmation of monogenic diabetes caused by glucokinase mutations (GCK-MODY) allows pharmacogenetic intervention in the form of insulin discontinuation. This is especially important among paediatric and young adult populations where GCK-MODY is most prevalent. METHODS:The study evaluated the utility of l...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Fendler W,Borowiec M,Antosik K,Szadkowska A,Deja G,Jarosz-Chobot P,Mysliwiec M,Wyka K,Pietrzak I,Skupien J,Malecki MT,Mlynarski W

    更新日期:2011-09-01 00:00:00

  • Intrauterine growth restriction (IUGR) is associated with increased leptin synthesis and binding capability in neonates.

    abstract:OBJECTIVE:Animal studies suggest pathological foetal programming of hypothalamic circuits regulating food intake in the setting of leptin deficiency and intrauterine growth restriction (IUGR). We aimed to compare placental leptin synthesis and leptin-binding capability in venous cord blood between IUGR newborns and neo...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Tzschoppe A,Struwe E,Rascher W,Dörr HG,Schild RL,Goecke TW,Beckmann MW,Hofner B,Kratzsch J,Dötsch J

    更新日期:2011-04-01 00:00:00

  • Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males.

    abstract:BACKGROUND:We recently identified a novel anorexigenic protein, nesfatin-1, which is processed from nesfatin/nucleobindin-2 (NUCB2). However, the clinical importance of this protein has not been determined. OBJECTIVE:To investigate its clinical significance in humans, we have established a new specific enzyme-linked i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Tsuchiya T,Shimizu H,Yamada M,Osaki A,Oh-I S,Ariyama Y,Takahashi H,Okada S,Hashimoto K,Satoh T,Kojima M,Mori M

    更新日期:2010-10-01 00:00:00

  • Variation in absorption and half-life of hydrocortisone influence plasma cortisol concentrations.

    abstract:BACKGROUND:Hydrocortisone therapy should be individualized in congenital adrenal hyperplasia (CAH) patients to avoid over and under replacement. We have assessed how differences in absorption and half-life of cortisol influence glucocorticoid exposure. PATIENTS AND METHODS:Forty-eight patients (21 M) aged between 6·1 ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hindmarsh PC,Charmandari E

    更新日期:2015-04-01 00:00:00

  • Oestrogen formation from androstenedione in human bone.

    abstract:BACKGROUND AND OBJECTIVE:Peripheral aromatization of testosterone and androstenedione is the principal source for circulating oestrogens in men and in castrated and post-menopausal women. Since human bone is a target organ for androgens and oestrogens, aromatase activity was assessed in human spongiosa obtained from pa...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Schweikert HU,Wolf L,Romalo G

    更新日期:1995-07-01 00:00:00

  • FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance.

    abstract:OBJECTIVE:The chromosomal regions containing the two putative tumour suppressors, fragile histidine triad gene (FHIT) and tumour suppressor gene 101 (TSG101), are deleted frequently in thyroid tumours. We therefore analysed FHIT and TSG101 transcripts in a group of advanced thyroid tumours to establish their role in th...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: McIver B,Grebe SK,Wang L,Hay ID,Yokomizo A,Liu W,Goellner JR,Grant CS,Smith DI,Eberhardt NL

    更新日期:2000-06-01 00:00:00

  • Prolactin levels in hypothyroid and euthyroid infants during the first week of life.

    abstract::A radioimmunoassay (RIA) procedure was devised for the estimation of PRL in eluates of dried whole blood from filter paper. Levels of PRL were measured in newborn blood obtained during the first week of life from 530 infants of normal birthweight (greater than 2500 g) with normal T4 values, 114 infants of normal birth...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mitchell ML,Hermos RJ,Bennett JE,McKenna JJ,Mitchell EL

    更新日期:1986-01-01 00:00:00

  • Long-term treatment with pegvisomant for acromegaly: a 10-year experience.

    abstract:BACKGROUND:Efficacy of the GH-receptor antagonist pegvisomant (PEG) has differed between preclinical and observational studies mainly due to dose adjustment and IGF-I normalization criteria. An escape phenomenon has also been described, but its definition and underlying causes have not been fully established. OBJECTIV...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Ramos-Leví AM,Bernabeu I,Álvarez-Escolá C,Aller J,Lucas T,de Miguel P,Rodríguez-Cañete L,Sampedro-Núñez MA,Halperin I,Puig-Domingo M,Marazuela M

    更新日期:2016-04-01 00:00:00

  • Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population.

    abstract:OBJECTIVE:Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wu X,Zhu X,Wang X,Ma J,Zhu S,Li J,Liu Y

    更新日期:2009-07-01 00:00:00

  • Ovarian and placental hormones during prolactin suppression and stimulation in early human pregnancy.

    abstract::Twenty-seven healthy females referred for legal abortion between the sixth and ninth week of pregnancy were treated for 1 week with either bromocriptine, metoclopramide or placebo. Serum prolactin was significantly (P < 0.01) elevated by metoclopramide and suppressed by bromocriptine. Despite a more than tenfold diffe...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Andersen AN,Hertz J,Kjer JJ,Eskildsen PC,Larsen PS,Svenstrup B,Nielsen J,Arends J

    更新日期:1980-08-01 00:00:00

  • Extensive experience in the management of macroprolactinomas.

    abstract:OBJECTIVES:Macroprolactinomas are pituitary tumours that can be managed with dopamine agonists (DA), surgery and radiotherapy. We aimed to assess the outcomes of these treatment modalities. DESIGN:Retrospective case-note study of patients managed in a single tertiary referral centre. PATIENTS:One hundred patients (68...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Green AI,Sherlock M,Stewart PM,Gittoes NJ,Toogood AA

    更新日期:2014-07-01 00:00:00

  • Effects of alpha-1 adrenergic blockade on the hormonal response to hypoglycaemic stress in normal man.

    abstract::In order to evaluate the effect of alpha-1 adrenoreceptor regulation of ACTH release during insulin-induced hypoglycaemia, we studied the response to hypoglycaemia with and without prazosin premedication in eight normal men. Prazosin pretreatment did not affect basal or peak plasma ACTH, cortisol or GH during hypoglyc...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cuneo RC,Livesey JH,Nicholls MG,Espiner EA,Donald RA

    更新日期:1987-01-01 00:00:00

  • Serum total adiponectin level and risk of cardiovascular disease in Han Chinese populations: a meta-analysis of 17 case-control studies.

    abstract:OBJECTIVE:To systematically evaluate low serum adiponectin level as a risk factor for cardiovascular disease (CVD). A meta-analysis was performed to quantitatively analyse the association of serum total adiponectin level with CVD using previous case-control studies in Han Chinese populations. METHODS:Several electroni...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析


    authors: Zhang BC,Liu WJ,Che WL,Xu YW

    更新日期:2012-09-01 00:00:00

  • Testosterone administration increases adrenal response to adrenocorticotrophin.

    abstract:OBJECTIVE:Various studies have demonstrated coexistence of ovarian and adrenal hyperandrogenism in women. This study was designed to determine whether testosterone can increase the response of the adrenal gland to stimulation by adrenocorticotrophin (ACTH). DESIGN:Non-randomized intervention in a university teaching h...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Polderman KH,Gooren LJ,van der Veen EA

    更新日期:1994-05-01 00:00:00