Serum prolactin concentration in patients taking neuroleptic drugs.

Abstract:

OBJECTIVE:Non-tumour causes of hyperprolactinaemia, including prolactin-elevating drugs, must be excluded. There is a general view that such drugs are unlikely to raise serum PRL above 3000 mU/I, but the literature is confusing. We report 8 patients receiving treatment with neuroleptic drugs, whose serum PRL concentrations were grossly elevated. METHODS:Prolactin was measured using a 2-site immunofluorometric assay (Abbott Laboratories; reference range < 500 mU/l). Seven of the eight women (age range 24-49 years) were symptomatic (galactorrhoea, oligo- or amenorrhoea). RESULTS:Prolactin concentrations ranged from 3600 mU/l to 7300 mU/l. All patients had a normal pituitary CT scan. Five patients were treated with bromocriptine without detriment to their mental state. CONCLUSION:Prolactin can rise to concentrations associated with prolactinomas in patients on neuroleptic drugs. As it is rarely possible to stop the drugs to see if the PRL concentration will decline to normal, neuroradiology is required in these patients to exclude a vision-threatening macroprolactinoma before deciding on medical treatment.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Pollock A,McLaren EH

doi

10.1046/j.1365-2265.1998.00569.x

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

513-6

issue

4

eissn

0300-0664

issn

1365-2265

journal_volume

49

pub_type

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