Characteristics of patients with normal T3 and T4 and a low TSH response to TRH.

abstract：OBJECTIVE:To determine if patients with untreated Cushing's disease have higher serum insulin-like growth factor-1 (IGF-1) compared to matched controls, and if IGF-1 decreases following remission of Cushing's disease. DESIGN:Retrospective case-control study matching Cushing's disease cases to control patients for aden...

journal_title：Clinical endocrinology

authors： English K,Chikani V,Dimeski G,Inder WJ

更新日期：2019-07-01 00:00:00

abstract：:Three different forms of testosterone (T) replacement therapy were compared; they were the intramuscular injection of mixed testosterone esters 250 mg; the subcutaneous implantation of 6 X 100 mg pellets of fused testosterone; and the oral administration of testosterone undecanoate (TU) 80 mg twice daily. Six hypogona...

journal_title：Clinical endocrinology

authors： Cantrill JA,Dewis P,Large DM,Newman M,Anderson DC

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM:To analyse tissue levels of adipon...

journal_title：Clinical endocrinology

authors： Karaduman M,Sengul A,Oktenli C,Pekel A,Yesilova Z,Musabak U,Sanisoglu SY,Gunay C,Baysan O,Kocar IH,Tatar H,Ozata M

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA). DESIGN:Cross-sectional,...

journal_title：Clinical endocrinology

authors： López-Bermejo A,Casano-Sancho P,Fernández-Real JM,Kihara S,Funahashi T,Rodríguez-Hierro F,Ricart W,Ibañez L

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism...

journal_title：Clinical endocrinology

authors： Di Nisio A,Rocca MS,Fadini GP,De Toni L,Marcuzzo G,Marescotti MC,Sanna M,Plebani M,Vettor R,Avogaro A,Foresta C

更新日期：2017-02-01 00:00:00

abstract：:A new radioreceptor assay for insulin-like growth factor-II (IGF-II), using receptors on ovine placental membranes, is described. Half-maximal displacement of specifically bound radioiodinated human IGF-II tracer was seen at 1.0 ng/tube of unlabelled IGF-II. The cross-reactivity of IGF-I was 1%, and insulin was entire...

journal_title：Clinical endocrinology

authors： Baxter RC,de Mellow JS

更新日期：1986-03-01 00:00:00

abstract：:Twenty-seven patients starting regular haemodialysis were treated with a 1 microgram daily dose of 1alpha-hydroxyvitamin D3 and concurrent aluminium hydroxide therapy to prevent hyperphosphataemia. There was an increase in plasma calcium, but no significant improvement in plasma alkaline phosphatase activity or parath...

journal_title：Clinical endocrinology

authors： Walker GS,Peacock M,Aaron J,Robinson PJ,Davison AM

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVES:Cytokines have an important role in orchestrating the pathophysiology in autoimmune thyroid disease. The aim of the current study was to analyse the expression of interleukin (IL)-14 and IL-16 in the thyroid tissue of patients with Graves' disease (GD), Hashimoto's thyroiditis (HT) or multinodular goitre (MN...

journal_title：Clinical endocrinology

authors： Kemp EH,Ajjan RA,Metcalfe RA,Watson PF,Weetman AP

更新日期：2015-11-01 00:00:00

abstract：:A receptor assay for TSH receptor antibodies is described in which unextracted serum, detergent solubilised TSH receptors and 125I-labelled TSH are used. The assay was rapid and reproducible with coefficients of inter-assay variation of 12.3%, 2.1 and 2.6% at mean inhibition of TSH binding values of 11, 53, and 79 res...

journal_title：Clinical endocrinology

authors： Southgate K,Creagh F,Teece M,Kingswood C,Rees Smith B

更新日期：1984-05-01 00:00:00

abstract：:In a series of hyperthyroid subjects treated with a high dose 'block-replace' regime, mean thyroidal technetium uptake was shown to fall progressively over an 18 month period. Furthermore, sub-total inhibition of hormone biosynthesis could be demonstrated, without evidence of proportionate inhibition of organification...

journal_title：Clinical endocrinology

authors： Wise PH,Marion M,Pain R

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVE:This case series documents the response of nine individuals with glucocorticoid-refractory Graves' orbitopathy (GO) to B cell depletion therapy with rituximab (RTX). CONTEXT:Graves' disease (GD) is one of the commonest autoimmune conditions and is frequently associated with inflammatory changes around the ey...

journal_title：Clinical endocrinology

authors： Mitchell AL,Gan EH,Morris M,Johnson K,Neoh C,Dickinson AJ,Perros P,Pearce SH

更新日期：2013-09-01 00:00:00

abstract：:Seven women with primary amenorrhoea and hyperprolactinaemia were treated with bromocriptine. All the women had started to develop secondary sex characteristics at normal age but pubertal development stopped and menarche did not occur. Radiological signs of a pituitary tumour were found in all the women. Before the pi...

journal_title：Clinical endocrinology

authors： Bergh T,Nillius SJ,Wide L

更新日期：1979-02-01 00:00:00

abstract：OBJECTIVE:ACTH-producing non-pituitary tumours are often associated with altered precursor processing, particularly in the most aggressive ones. Since placental tissue is characterized by its ability to express the proopiomelanocortin (POMC) gene and rapid cellular proliferation, we examined whether intact POMC could b...

journal_title：Clinical endocrinology

authors： Raffin-Sanson ML,Massias JF,Ankotche A,Coste J,de Keyzer Y,Oliver C,Dumont C,Cabrol D,Ferré F,Bertagna X

更新日期：1999-01-01 00:00:00

abstract：:It has been reported that administration of nomifensine (Nom) or of L-dopa + carbidopa (L-dopa + Carb) potentiates central dopaminergic tonus, resulting in decreased prolactin (PRL) secretion. It has been proposed that these drugs would help to discriminate patients with PRL-secreting pituitary tumours from those with...

journal_title：Clinical endocrinology

authors： Moriondo P,Travaglini P,Nissim M,Faglia G

更新日期：1980-12-01 00:00:00

abstract：OBJECTIVE:Correction of GH and IGF-I levels are associated with improvements in insulin secretion, cardiac performance and body composition in patients with acromegaly, but whether these parallel post-treatment levels of GH-IGF-I axis activity is undefined. We investigate whether various biochemical outcomes after tran...

journal_title：Clinical endocrinology

authors： Damjanovic SS,Neskovic AN,Petakov MS,Popovic V,Macut D,Vukojevic P,Joksimovic MM

更新日期：2005-04-01 00:00:00

abstract：:100 mg i.m. sulpiride (a dopamine-receptor-blocking drug) led to a significant rise in plasma TSH in normal womem, in female patients with galactorrhoea, and, to a much more marked degree, in male and female patients with primary hypothyroidism. In the hypothyroid patients, there was a significant positive correlation...

journal_title：Clinical endocrinology

authors： Massara F,Camanni F,Belforte L,Vergano V,Molinatti GM

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVES:There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this a...

journal_title：Clinical endocrinology

authors： Choi SH,An JH,Lim S,Koo BK,Park SE,Chang HJ,Choi SI,Park YJ,Park KS,Jang HC,Shin CS

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To study the mechanism through which mifepristone interrupts folliculogenesis. DESIGN:Normally ovulating women undergoing donor intrauterine insemination (IUI) treatment were investigated during two menstrual cycles treated with gonadotrophins. In the first cycle (FSH cycle), the women were given 150 IU reco...

journal_title：Clinical endocrinology

authors： Messinis IE,Krishnan M,Kazem R,Khadilkar S,Templeton AA

更新日期：1997-03-01 00:00:00

abstract：:We have examined the characteristics of circulating immunoreactive human calcitonin (IR-hCT) by studying its different molecular weight (MW) forms under various secretory conditions in a patient with medullary carcinoma of the thyroid. Plasma IR-hCT (318 mg/l basal) increased 9 and 12 times, respectively, after calciu...

journal_title：Clinical endocrinology

authors： Bertagna XY,Bloomgarden ZT,Rabin D,Roberts LJ,Orth DN

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:There has been a rapid shift from open to laparoscopic approaches in adrenal surgery, but the safety and efficacy of bilateral laparoscopic adrenalectomy (BLA) in patients with corticotrophin (ACTH)-dependent Cushing's syndrome continues to be defined. OBJECTIVE:Review outcomes in the largest series of pati...

journal_title：Clinical endocrinology

authors： Chow JT,Thompson GB,Grant CS,Farley DR,Richards ML,Young WF Jr

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:The diagnosis of growth hormone deficiency (GHD) in adults is established through growth hormone (GH) stimulation testing, which is often complex, expensive, time-consuming and may be associated with adverse side effects. The decision to perform GH provocative testing is influenced by clinical findings, medic...

journal_title：Clinical endocrinology

authors： Zgaljardic DJ,Guttikonda S,Grady JJ,Gilkison CR,Mossberg KA,High WM Jr,Masel BE,Urban RJ

更新日期：2011-03-01 00:00:00

abstract：:1 alpha, 25-Dihydroxycholecalciferol (1,25-(OH)2D3) has been measured in human serum by radioimmunoassay. The assay uses a high titre antiserum raised in sheep against 1,25-(OH)2D3-25-hemisuccinate, conjugated to bovine serum albumin. The sensitivity of the assay is 10 pg/tube. Other hydroxylated forms of vitamin D3 c...

journal_title：Clinical endocrinology

authors： Clemens TL,Hendy GN,Papapoulos SE,Fraher LJ,Care AD,O'Riordan JL

更新日期：1979-01-01 00:00:00

abstract：:Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) prese...

journal_title：Clinical endocrinology

authors： Bannister P,Sheridan P,Losowsky MS

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by chronic anovulation, hyperandrogenism, polycystic ovary morphology (PCOM) and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, r...

journal_title：Clinical endocrinology

authors： Hong SH,Sung YA,Hong YS,Jeong K,Chung H,Lee H

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:We assessed body composition, bone mineral density (BMD), glucose and lipids in Williams syndrome (WS), a rare microdeletion disorder. DESIGN:Individuals with WS had outpatient assessment at Massachusetts General Hospital. Controls were selected from the National Health and Nutrition Examination Survey (NHAN...

journal_title：Clinical endocrinology

authors： Shaikh S,Waxler JL,Lee H,Grinke K,Garry J,Pober BR,Stanley TL

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN:In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS:Nine patients with overt primary hypothyroidism...

journal_title：Clinical endocrinology

authors： Adriaanse R,Brabant G,Prank K,Endert E,Wiersinga WM

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVES:An inverse relationship has been shown between body mass index (BMI) and the peak growth hormone (GH) response to stimulation in adults and in children with short stature. This relation is observed even within a normal range of BMI. The aim of this study was to investigate the effect of BMI on the GH respons...

journal_title：Clinical endocrinology

authors： Loche S,Guzzetti C,Pilia S,Ibba A,Civolani P,Porcu M,Minerba L,Casini MR

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:We investigated interindividual differences in the shape, slope and setpoint of the pituitary-thyroid axis (PTA) in normal persons. Based on these physiological data we propose a novel bivariate concept for the interpretation of thyroid function tests which is less biased by interindividual differences in the...

journal_title：Clinical endocrinology

authors： Meier CA,Maisey MN,Lowry A,Müller J,Smith MA

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Little is known about the dose-response relationship of potential, unwanted, effects of inhaled beclomethasone (BDP) on the hypothalamo-pituitary-adrenal (HPA) axis, particularly in nonspecialist clinic settings. The purpose of our study was to investigate the dose-response relationship of inhaled BDP on the ...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Durham JA,Kljakovic M,Cooke RR

更新日期：1997-09-01 00:00:00

abstract：UNLABELLED:A diagnosis of bilateral pheochromocytoma warrants exclusion of hereditary pheochromocytoma. OBJECTIVE:To describe the first case of a bilateral pheochromocytoma associated with V804M mutation in the RET proto-oncogene. PATIENTS:The index case was a 54-year-old man with bilateral adrenal masses discovered ...

journal_title：Clinical endocrinology

authors： Recasens M,Oriola J,Fernández-Real JM,Roig J,Rodríguez-Hermosa JI,Font JA,Galofre P,López-Bermejo A,Ricart W

更新日期：2007-07-01 00:00:00