Abstract:
OBJECTIVE:Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA). DESIGN:Cross-sectional, hospital-based study dealing with insulin sensitivity in SGA children. PATIENTS:Thirty-two prepubertal children born SGA (age 5.4 +/- 2.9 years) and 37 prepubertal children born appropriate for gestational age (AGA, age 5.9 +/- 3.0 years). MEASUREMENTS:Serum levels of fasting glucose, serum lipids, insulin (immunometric assay) and adiponectin concentrations (ELISA) were assessed, and insulin resistance (IR) and insulin secretion (beta-cell) were calculated by the homeostasis model of assessment (HOMA). RESULTS:SGA children had similar HOMA-IR, HOMA-beta-cell and adiponectin concentrations than AGA children. However, in a separate analysis of subjects older than 3 years of age, SGA children showed higher HOMA-IR after adjusting for sex, age and body mass index (BMI) standard deviation score (SDS). Circulating adiponectin was higher in SGA children [adjusted means: 14.5 mg/l (95% CI 12.9-16.1) and 18.7 mg/l (95% CI 17.0-20.3) for AGA and SGA children, respectively; P < 0.0001]. Further analysis revealed that the group of overweight SGA (arbitrarily defined as being in the higher quartile for the BMI SDS distribution in the sample) had decreased serum concentrations of adiponectin, compared to lean SGA children [adjusted means: 12.9 mg/l (95% CI 9.3-16.5) vs. 19.0 (95% CI 16.8-21.3), respectively; P = 0.001]. In a multiple regression model, HOMA-IR and SGA status explained 35% and 15% of adiponectin variance, respectively. CONCLUSIONS:Prenatal growth restriction is associated with insulin resistance but relatively increased adiponectin concentrations, provided overweight does not ensue. The contributions of circulating adiponectin to the increased risks for developing insulin resistance and type-2 diabetes in formerly SGA subjects merit further studies.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
López-Bermejo A,Casano-Sancho P,Fernández-Real JM,Kihara S,Funahashi T,Rodríguez-Hierro F,Ricart W,Ibañez Ldoi
10.1111/j.1365-2265.2004.02102.xkeywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
339-46issue
3eissn
0300-0664issn
1365-2265pii
CEN2102journal_volume
61pub_type
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更新日期:2009-03-01 00:00:00
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doi:10.1111/j.1365-2265.2004.02162.x
更新日期:2004-12-01 00:00:00
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更新日期:1996-04-01 00:00:00
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doi:10.1111/j.1365-2265.1991.tb00325.x
更新日期:1991-06-01 00:00:00
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doi:10.1111/j.1365-2265.2007.02820.x
更新日期:2007-06-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1990.tb00507.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1988.tb01213.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1985.tb00205.x
更新日期:1985-08-01 00:00:00
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更新日期:1998-09-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-05-01 00:00:00
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.2005.02367.x
更新日期:2005-10-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.2008.03431.x
更新日期:2009-06-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/cen.14389
更新日期:2020-12-09 00:00:00