Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area.

abstract：OBJECTIVE:To investigate two patients with the hyperparathyroidism-jaw tumour (HPT-JT) syndrome and three patients with familial isolated hyperparathyroidism (FIHP), together with 31 parathyroid tumours (2 HPT-JT, 2 FIHP and 27 sporadic) for HRPT2 mutations. The HPT-JT syndrome and FIHP are autosomal dominant disorders...

journal_title：Clinical endocrinology

authors： Bradley KJ,Cavaco BM,Bowl MR,Harding B,Cranston T,Fratter C,Besser GM,Conceição Pereira M,Davie MW,Dudley N,Leite V,Sadler GP,Seller A,Thakker RV

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:Both severe growth hormone (GH) deficiency in hypopituitary adults and physiological ageing are associated with an increase in fat mass, dyslipidaemia, and an increased incidence of cardiovascular disease. Ageing is also associated with a physiological decrease in spontaneous as well as stimulated GH secretio...

journal_title：Clinical endocrinology

authors： Vahl N,Klausen I,Christiansen JS,Jørgensen JO

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The distinction between benign and malignant well-differentiated endocrine tumours is hard to achieve. The aim of the present study was to determine whether detection of telomerase or quantification of human telomerase reverse transcriptase protein subunit (hTERT) differ between benign and malignant endocrine...

journal_title：Clinical endocrinology

authors： Vezzosi D,Bouisson M,Escourrou G,Laurell H,Selves J,Seguin P,Pradayrol L,Caron P,Buscail L

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evolution over time. The second obj...

journal_title：Clinical endocrinology

authors： Palermo A,Jacques R,Gossiel F,Reid DM,Roux C,Felsenberg D,Glueer CC,Eastell R

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Mutations in the melanocortin-4 receptor gene (MC4R) are the most common monogenic form of human obesity. However, the contribution of MC4R mutations to obesity in Chinese has not been investigated. We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequen...

journal_title：Clinical endocrinology

authors： Rong R,Tao YX,Cheung BM,Xu A,Cheung GC,Lam KS

更新日期：2006-08-01 00:00:00

abstract：CONTEXT:Vitamin D-dependent rickets type 1A (VDDR-IA, OMIM 264700) is a rare autosomal recessive disorder and is caused by mutations in the CYP27B1 gene. OBJECTIVES:We aim to investigate CYP27B1 mutation in seven patients from four separate families and characterize the genotype-phenotype correlation. METHODS:The ent...

journal_title：Clinical endocrinology

authors： Durmaz E,Zou M,Al-Rijjal RA,Bircan I,Akçurin S,Meyer B,Shi Y

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:The prevalence of autoimmune polyendocrine syndrome type 1 (APS1) among isolated hypoparathyroidism (HP) or primary adrenal insufficiency (PAI) is not well established. We studied the frequency of APS1 in patients with HP or PAI by measuring interferon-α (IFN-α) antibody levels, a highly sensitive and specifi...

journal_title：Clinical endocrinology

authors： Sahoo SK,Zaidi G,Srivastava R,Sarangi AN,Bharti N,Eriksson D,Bensing S,Kämpe O,Aggarwal A,Aggarwal R,Bhatia E

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...

journal_title：Clinical endocrinology

authors： Limor R,Tordjman K,Marcus Y,Greenman Y,Osher E,Sofer Y,Stern N

更新日期：2011-09-01 00:00:00

abstract：:The case reported is of a 46-year-old woman who had congenital adrenal hyperplasia due to a 21-hydroxylase deficiency, and in whom there was the development of an ACTH secreting pituitary tumour. The patient was untreated with glucocorticoids until the age of 32 years when she presented with infertility. She next pres...

journal_title：Clinical endocrinology

authors： Horrocks PM,Franks S,Hockley AD,Rolfe EB,Van Noorden S,London DR

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

journal_title：Clinical endocrinology

authors： Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Controversial data on ghrelin concentration during exercise in human subjects have been published. We tested the hypothesis that exercise could affect acylated ghrelin (AG) and unacylated ghrelin (UAG), which could partly explain the previously reported inconsistent findings on the association of exercise wit...

journal_title：Clinical endocrinology

authors： Kim HJ,Lee S,Kim TW,Kim HH,Jeon TY,Yoon YS,Oh SW,Kwak H,Lee JG

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF-like repeat-containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc-dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower insulin sensitivity. Dlk1-def...

journal_title：Clinical endocrinology

authors： Hermida C,Garcés C,de Oya M,Cano B,Martínez-Costa OH,Rivero S,García-Ramírez JJ,Laborda J,Aragón JJ

更新日期：2008-08-01 00:00:00

abstract：:Thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of Ubangi, Northern Zaire. Serum T4 was at the lower limit of normal at birth (104 +/- 4 nm...

journal_title：Clinical endocrinology

authors： Vanderpas J,Bourdoux P,Lagasse R,Rivera M,Dramaix M,Lody D,Nelson G,Delange F,Ermans AM,Thilly CH

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended ...

journal_title：Clinical endocrinology

authors： Kim HW,Park H,Cho KH,Han K,Ko BJ

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. DESIGN:Prospective cohort. PATIENTS AND MEASUREMENTS:Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screeni...

journal_title：Clinical endocrinology

authors： Bahri Khomami M,Moran LJ,Kenny L,Grieger JA,Myers J,Poston L,McCowan L,Walker J,Dekker G,Norman R,Roberts CT

更新日期：2019-06-01 00:00:00

abstract：:The purpose of this study was to assess the normal relationship between plasma ACTH and cortisol during insulin induced hypoglycaemia. Twenty-six healthy persons were studied. Peak plasma concentration and the amounts of ACTH and cortisol secreted during hypoglycaemia were compared. There was no significant correlatio...

journal_title：Clinical endocrinology

authors： Lindholm J,Kehlet H,Blichert-Toft M,Riishede J,Hummer L,Dinesen B

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:It has previously been shown that higher serum TSH is associated with increased thyroid cancer incidence and advanced-stage disease. In the healthy adult population, mean TSH increases with age. As age over 45 years is a known prognostic indicator for thyroid cancer, it is important to know whether higher TS...

journal_title：Clinical endocrinology

authors： Haymart MR,Glinberg SL,Liu J,Sippel RS,Jaume JC,Chen H

更新日期：2009-09-01 00:00:00

abstract：:The biological response, as measured in the cytochemical bioassay, to the high circulating levels of immunoreactive parathyroid hormone (iPTH) in patients with pseudohypoparathyroidism type I (PSPI) is affected by the presence of an endogenous inhibitor. This is evidenced by the reduced recovery of the biological acti...

journal_title：Clinical endocrinology

authors： Loveridge N,Fischer JA,Devogelaer JP,Nagant de Deuxchaisnes C

更新日期：1986-05-01 00:00:00

abstract：:The ultrastructural effects of a Leydig cell tumour of the testis on nontumorous testicular tissue have not yet been reported. Described here are the electron microscopic findings in the nonneoplastic testicular tissue of a patient with a feminizing testicular Leydig cell neoplasm. Serial studies were carried out over...

journal_title：Clinical endocrinology

authors： Sohval AR,Churg J,Suzuki Y,Katz N,Gabrilove JL

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

journal_title：Clinical endocrinology

authors： Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:The frequency and the degree of recovery of anterior pituitary hormone deficits in patients with macroprolactinoma responsive to cabergoline are not clear. Our aim was to evaluate pituitary function in these patients with particular reference to an assessment of the possible restoration of pituitary deficits....

journal_title：Clinical endocrinology

authors： Karavitaki N,Dobrescu R,Byrne JV,Grossman AB,Wass JA

更新日期：2013-08-01 00:00:00

abstract：CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

journal_title：Clinical endocrinology

authors： D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

更新日期：2013-03-01 00:00:00

abstract：:The effect of pretreatment with biosynthetic methionyl human GH (hGH) on the GH response to GHRH has been studied in normal subjects. Eight volunteers were given either 4 IU hGH or placebo s.c. 12-hourly for 72 h before a GHRH test, or a single s.c. dose of 4 IU hGH 12 h before a GHRH test. Somatomedin-C (Sm-C) levels...

journal_title：Clinical endocrinology

authors： Ross RJ,Borges F,Grossman A,Smith R,Ngahfoong L,Rees LH,Savage MO,Besser GM

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:The thyroid suppression test is still used in some centres as an adjunt in the diagnosis of autonomous functioning thyroid nodules. With the purpose of minimizing the disadvantages of the original T3 suppression test, we have evaluated the efficacy of a method using L-thyroxine as TSH suppression agent and [9...

journal_title：Clinical endocrinology

authors： Ramos CD,Zantut-Wittmann DE,Tambascia MA,Assumpção L,Etchebehere EC,Camargo EE

更新日期：2000-04-01 00:00:00

abstract：:Delayed puberty is defined arbitrarily on the basis of statistical consideration, when no signs of puberty have occurred at 2.0 SD (13.4 years in girls and 13.8 in boys) above the mean chronological age for the onset of puberty. The vast majority of these patients have no endocrine abnormality and their pubertal devel...

journal_title：Clinical endocrinology

authors： Albanese A,Stanhope R

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:Low growth hormone (GH) secretion and hypogonadism are common in patients with Prader-Willi syndrome (PWS). In this study we present the effects of GH treatment on body composition and metabolism in adults with PWS. PATIENTS AND MEASUREMENTS:Nineteen patients with clinical PWS were recruited, 13 had PWS geno...

journal_title：Clinical endocrinology

authors： Höybye C,Hilding A,Jacobsson H,Thorén M

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Between 10 and 30% of the fine needle aspiration biopsies (FNABs) of thyroid nodules are diagnosed as 'indeterminate'. A molecular diagnostic method is needed to reduce unnecessary surgery in this group. In Korea, most thyroid cancer is the classic papillary type and the BRAF(V600E) mutation is highly preval...

journal_title：Clinical endocrinology

authors： Chung KW,Yang SK,Lee GK,Kim EY,Kwon S,Lee SH,Park DJ,Lee HS,Cho BY,Lee ES,Kim SW

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to observe the changes in bone and mineral metabolism and to confirm the regulation of fibroblast growth factor-23 (FGF-23) in untreated Graves' disease. PATIENTS AND MEASUREMENTS:The study comprised 39 patients, with or without Graves' disease. The Graves' disease group was made up...

journal_title：Clinical endocrinology

authors： Park SE,Cho MA,Kim SH,Rhee Y,Kang ES,Ahn CW,Cha BS,Lee EJ,Kim KR,Lee HC,Lim SK

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:The rates of sensitivity and specificity of fine needle aspiration biopsy (FNAB) for the diagnosis of thyroid malignancy differ considerably among various reported series. These values are influenced by three factors: (a) whether only clearly positive and negative results are considered, or whether the com...

journal_title：Clinical endocrinology

authors： Cáp J,Ryska A,Rehorková P,Hovorková E,Kerekes Z,Pohnetalová D

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

journal_title：Clinical endocrinology

authors： Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

更新日期：2016-02-01 00:00:00