Growth hormone pretreatment in man blocks the response to growth hormone-releasing hormone; evidence for a direct effect of growth hormone.

abstract：BACKGROUND:The development of hepatocellular carcinoma in liver cirrhosis is associated with altered synthesis and secretion of several growth factors. AIM:The aim of this prospective study was to investigate the potential implication of IGF-I and its major binding protein (IGFBP-3) in the development of hepatocellula...

journal_title：Clinical endocrinology

authors： Mattera D,Capuano G,Colao A,Pivonello R,Manguso F,Puzziello A,D'Agostino L

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Infusion of GH secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted GH secretion associated with a substantial IGF-I rise. Here we report the dynamic characteristics of spontaneous nightly TSH and PRL secre...

journal_title：Clinical endocrinology

authors： Van den Berghe G,de Zegher F,Veldhuis JD,Wouters P,Gouwy S,Stockman W,Weekers F,Schetz M,Lauwers P,Bouillon R,Bowers CY

更新日期：1997-11-01 00:00:00

abstract：:The age-dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in the elderly by their effects on muscle mass and bone mineral density. However, for healthy men data on serum oestrogens and androgens, as well as IGF-1, as a common outcome measure covering the whole adult age range ar...

journal_title：Clinical endocrinology

authors： Leifke E,Gorenoi V,Wichers C,Von Zur Mühlen A,Von Büren E,Brabant G

更新日期：2000-12-01 00:00:00

abstract：:The human population which lives and works in polar environments has been increasing steadily over the last 15 years. Very little is known about how these residents adjust to their environment. Cold adaptation in man is a poorly understood phenomenon. Euthermic mammals maintain body temperature during cold exposure vi...

journal_title：Clinical endocrinology

authors： Reed HL,Burman KD,Shakir KM,O'Brian JT

更新日期：1986-07-01 00:00:00

abstract：OBJECTIVE:The chromosomal regions containing the two putative tumour suppressors, fragile histidine triad gene (FHIT) and tumour suppressor gene 101 (TSG101), are deleted frequently in thyroid tumours. We therefore analysed FHIT and TSG101 transcripts in a group of advanced thyroid tumours to establish their role in th...

journal_title：Clinical endocrinology

authors： McIver B,Grebe SK,Wang L,Hay ID,Yokomizo A,Liu W,Goellner JR,Grant CS,Smith DI,Eberhardt NL

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Patients on long-term dialysis may develop secondary hyperparathyroidism (SHPT), which causes varying degrees of bone mass loss. This condition is treated with parathyroidectomy (PTX). We investigated whether serial serum bone turnover markers could predict changes in bone mineral density (BMD) after PTX. DE...

journal_title：Clinical endocrinology

authors： Lu KC,Ma WY,Yu JC,Wu CC,Chu P

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

journal_title：Clinical endocrinology

authors： Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Previous studies report impaired health-related quality of life (HRQoL) in patients with functional pituitary adenomas (FPA). We assessed HRQoL in FPA patients having undergone surgery at our University Central Hospital between 2000 and 2010, with combined adjuvant treatment given to achieve strict hormonal ...

journal_title：Clinical endocrinology

authors： Ritvonen E,Karppinen A,Sintonen H,Vehkavaara S,Kivipelto L,Roine RP,Niemelä M,Schalin-Jäntti C

更新日期：2015-03-01 00:00:00

abstract：:After administration of intravenous metoclopramide, a dopaminergic receptor blocking agent, no rise in thyroid stimulating hormone (TSH) could be found in patients with chronic renal failure, in contrast to non-uraemic controls. Basal TSH values were normal in the uraemic patients but the TSH response to thyrotrophin-...

journal_title：Clinical endocrinology

authors： Weetman AP,Weightman DR,Scanlon MF

更新日期：1981-11-01 00:00:00

abstract：OBJECTIVE:A new protocol for postoperative calcium management was developed with the aim of achieving an increase in the proportion of patients being safely discharged on the first postoperative day. We present our experience with the first 50 patients treated under this new protocol. PATIENTS AND DESIGN:A cohort stud...

journal_title：Clinical endocrinology

authors： Grodski S,Lundgren CI,Sidhu S,Sywak M,Delbridge L

更新日期：2009-02-01 00:00:00

abstract：:Headache is very common in pituitary disease and is reported to be present in more than a third of all patients with pituitary adenomas. Tumour size, cavernous sinus invasion, traction or displacement of intracranial pain-sensitive structures such as blood vessels, cranial nerves and dura mater, and hormonal hypersecr...

journal_title：Clinical endocrinology

authors： Kreitschmann-Andermahr I,Siegel S,Weber Carneiro R,Maubach JM,Harbeck B,Brabant G

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:The prevalence of clinically silent corticotroph macroadenomas is unknown. Our aim was to determine the prevalence of clinically silent corticotroph macroadenomas among all pituitary macroadenomas. DESIGN:Patients scheduled to have transsphenoidal surgery for any sellar mass were prospectively evaluated clin...

journal_title：Clinical endocrinology

authors： Guttenberg KB,Mayson SE,Sawan C,Kharlip J,Lee JY,Martinez-Lage M,Loevner LA,Ewanichak J,Grady MS,Snyder PJ

更新日期：2016-12-01 00:00:00

abstract：:Twenty-seven patients starting regular haemodialysis were treated with a 1 microgram daily dose of 1alpha-hydroxyvitamin D3 and concurrent aluminium hydroxide therapy to prevent hyperphosphataemia. There was an increase in plasma calcium, but no significant improvement in plasma alkaline phosphatase activity or parath...

journal_title：Clinical endocrinology

authors： Walker GS,Peacock M,Aaron J,Robinson PJ,Davison AM

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:When the gonadotrophin levels increase at midcycle, more basic isoforms of FSH and LH appear in the circulation. However, when these gonadotrophins increase at menopause more acidic forms appear. The present study was done to see whether chronic 17 beta-oestradiol (E2) administration to post-menopausal women ...

journal_title：Clinical endocrinology

authors： Wide L,Naessén T

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVES:Associations between calcium-sensing receptor (CaSR) polymorphisms and serum calcium, PTH and bone mineral density (BMD) have been reported by six studies. However, three other studies have failed to detect such associations. We therefore further investigated three CaSR coding region polymorphisms (Ala986Ser...

journal_title：Clinical endocrinology

authors： Harding B,Curley AJ,Hannan FM,Christie PT,Bowl MR,Turner JJ,Barber M,Gillham-Nasenya I,Hampson G,Spector TD,Thakker RV

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:To define the symptoms, signs and treatment outcomes in a population of older patients with Cushing's disease (CD). METHODS:We analysed the clinical presentation and treatment outcomes in 45 CD patients older than 60 years, in comparison with 90 CD patients younger than 60, and a control group of 45 older p...

journal_title：Clinical endocrinology

authors： Qiao N,Swearingen B,Tritos NA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

journal_title：Clinical endocrinology

authors： Laursen T,Jørgensen JO,Christiansen JS

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle. We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the follicular and the luteal phase of the cycle. DESIGN:Normally ovulating women were studied during the ...

journal_title：Clinical endocrinology

authors： Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the volumetric bone mineral density (BMD) in girls with Turner's syndrome (TS) before and during growth hormone (GH) treatment in combination with low dose oestrogens as well as three years after discontinuation of GH treatment. DESIGN:In a prospective, randomized injectio...

journal_title：Clinical endocrinology

authors： Sass TC,De Muinck Keizer-Schrama SM,Stijnen T,Asarfi A,Van Leeuwen WJ,Van Teunenbroek A,Van Rijn RR,Drop SL

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:Low growth hormone (GH) secretion and hypogonadism are common in patients with Prader-Willi syndrome (PWS). In this study we present the effects of GH treatment on body composition and metabolism in adults with PWS. PATIENTS AND MEASUREMENTS:Nineteen patients with clinical PWS were recruited, 13 had PWS geno...

journal_title：Clinical endocrinology

authors： Höybye C,Hilding A,Jacobsson H,Thorén M

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:To explore vitamin D status in relation to diabetes, based on data from a national health examination survey in Thailand. DESIGN AND METHODS:A total of 2641 adults, aged 15-98 years, were randomly selected according to geographical region from the Thai 4th National Health Examination Survey sample. Logistic ...

journal_title：Clinical endocrinology

authors： Chailurkit LO,Aekplakorn W,Ongphiphadhanakul B

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN:In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS:Nine patients with overt primary hypothyroidism...

journal_title：Clinical endocrinology

authors： Adriaanse R,Brabant G,Prank K,Endert E,Wiersinga WM

更新日期：1992-12-01 00:00:00

abstract：:Plasma aldosterone (PA), plasma renin activity (PRA), extracellular fluid volume (EFV) and hepatic blood flow were measured in forty-four patients with sustained essential hypertension and compared with forty-two normotensive controls of same age and sex. All patient had inulin clearances within the normal range and b...

journal_title：Clinical endocrinology

authors： Safar ME,Simon AC,Dard SA,Parlier HR,Pauleau NE,Vincent ML,Sassard JE

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Whether nonalcoholic fatty liver disease (NAFLD) can predict atherosclerosis in obese patients remains unclear. The aim of our study was to investigate the usefulness of NAFLD and other cardiometabolic parameters in predicting subclinical atherosclerosis in obese patients. DESIGN, PATIENTS AND MEASUREMENTS:W...

journal_title：Clinical endocrinology

authors： Puig J,Blasco G,Daunis-I-Estadella J,Loshuertos E,Codina J,Cuba V,Ortiz R,Xifra G,Ricart W,Pedraza S,Federici M,Fernández-Real JM

更新日期：2015-08-01 00:00:00

abstract：:Phospholipase C activity was measured in human endometrium using an assay based on the release of total labelled water soluble products (inositol, inositol phosphates) from L-3-phosphatidyl-[2-3H] inositol. The enzyme was shown to be calcium dependent and to have an optimum pH of 5.5. There was no difference between p...

journal_title：Clinical endocrinology

authors： Bonney RC,Franks S

更新日期：1987-09-01 00:00:00

abstract：CONTEXT:Peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists such as thiazolidinediones (TZDs) improve insulin sensitivity in type 2 diabetes mellitus (T2DM) through effects on fat metabolism whereas GH stimulates lipolysis and induces insulin resistance. OBJECTIVE:To evaluate the impact of TZDs on f...

journal_title：Clinical endocrinology

authors： Krag MB,Nielsen S,Guo Z,Pedersen SB,Schmitz O,Christiansen JS,Jørgensen JO

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To determine the interest of Chromogranin A (CgA) determination for diagnosis and follow-up in patients with gastroenteropancreatic endocrine tumours (GEP-ET) and multiple endocrine neoplasia type 1 (MEN-1). PATIENTS AND METHODS:CgA levels were measured with an immunoradiometric assay in 124 sporadic GEP-ET,...

journal_title：Clinical endocrinology

authors： Nehar D,Lombard-Bohas C,Olivieri S,Claustrat B,Chayvialle JA,Penes MC,Sassolas G,Borson-Chazot F

更新日期：2004-05-01 00:00:00

abstract：:Biochemical markers of bone turnover are widely used in clinical practice. These indices have been shown to be associated with the occurrence, prognosis and therapeutic response of malignant bone lesions. For example, markers of bone resorption are often elevated in patients with established bone metastases and while ...

journal_title：Clinical endocrinology

authors： Seibel MJ

更新日期：2008-06-01 00:00:00

abstract：:Normal men and normally menstruating women received i.m. injections of 0.1 to 4.0 mg/kg sulpiride. This psychotropic drug induced a very rapid (already significant after 5 minutes) and sustained (still significant after 7 hours) elevation of prolactin (PRL) concentrations in all subjects with no consistent modificatio...

journal_title：Clinical endocrinology

authors： L'Hermite M,Denayer P,Golstein J,Virasoro E,Vanhaelst L,Copinschi G,Robyn C

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:We wished to assess the changes in serum IGF-I and IGF-II concentrations during gonadotrophin treatment alone or with additional GH treatment and to compare follicular fluid IGF-I and IGF-II concentrations in the two treatment groups. DESIGN:We performed an open study of co-treatment with GH and subsequently...

journal_title：Clinical endocrinology

authors： Owen EJ,Torresani T,West C,Mason BA,Jacobs HS

更新日期：1991-10-01 00:00:00